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Dasatinib monohydrate
BMS-354825 Monohydrate
T1448L863127-77-9
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
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TargetMol | Citations Cited
Dasatinib
BMS-354825
T1448302962-49-8
Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16 30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma.
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TargetMol | Citations Cited
Tauro-Obeticholic acid
T13092863239-61-6
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
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Glyco-Obeticholic acid
T11428863239-60-5
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
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Hydroxypinacolone Retinoate
T84262893412-73-2
Hydroxypinacolone Retinoate (HPR) is a retinoid commonly added to skin care products and can be used to study skin aging and acne.
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Secolongifolenediol
TN498253587-37-4
Secolongifolenediol is a natural product for research related to life sciences. The catalog number is TN4982 and the CAS number is 53587-37-4.
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Acolonifloroside K
T1245266251-64-5
Acolonifloroside K is a useful organic compound for research related to life sciences. The catalog number is T124526 and the CAS number is 6251-64-5.
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Curcolone
T125611
Curcolone is a useful organic compound for research related to life sciences and the catalog number is T125611.
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Curcolonol
TN3731217817-09-9
Curcolonol is a natural product of Curcuma, Zingiberaceae. The catalog number is TN3731 and the CAS number is 217817-09-9. Curcolonol can be used as a reference standard.
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1-Bromopinacolone
T718025469-26-1
1-Bromopinacolone is an active site-directed covalent inhibitor for acetylcholinesterase
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6-8 weeks
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Werner syndrome RecQ helicase-IN-1
T721072869954-34-5
Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
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10-14 weeks
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TargetMol | Inhibitor Hot
Gardenin A
TN411421187-73-5
Gardenin A shows neurotrophic effects via activating MAPK ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
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TargetMol | Inhibitor Hot
Ro-3306
T2356872573-93-8
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
mTOR inhibitor 9b
T677031144075-34-2In house
mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inhibitor 9b possesses anticancer activity and can be used to study leukemia, skin, breast, lung and colon cancers.
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8-10weeks
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TargetMol | Inhibitor Sale
Copper probe CF4
Copper probe CF-4, Copper probe CF 4, Copper fluor CF4, CF4 prob
T310082365532-64-3In house
Copper probe CF4 (Copper fluor CF4) is a fluorescent copper probe that can be used to study colon cancer.
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7-10 days
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TargetMol
Thymectacin
NB1011, NB-1011, NB 1011
T24881232925-18-7In house
Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.
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8-10 weeks
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L-161982
T15681147776-06-5In house
L-161982 is a selective EP4 receptor antagonist that inhibits PGE2-induced ERK phosphorylation and cell proliferation in HCA-7 cells and alleviates collagen-induced arthritis in mice.
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6-8 weeks
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AZA197
AZA 197, AZA-197
T251251249398-09-1In house
AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
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8-10weeks
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3CAI
T1403428755-03-5In house
3CAI is a potent and specific AKT1 and AKT2 inhibitor, demonstrating significant inhibition of AKT in an in vitro kinase assay. It suppressed the expression of AKT direct downstream targets (such as mTOR and GSK3β) and induced growth inhibition and apoptosis in colon cancer cells.
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6-8 weeks
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CG 428
T412242412055-93-5In house
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide. CG 428 shows selectivity for TRKA over TRKC and TRKB with Kds of 1nM, 4.2 nM, and 28 nM. CG 428 inhibits the growth of KM12 colon cancer cells with an IC50 of 2.9 nM.
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8-10weeks
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AK301
AK-301, AK 301
T26585314022-97-4In house
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release.
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6-8 weeks
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N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea
T7359275219-93-1In house
N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has antitumor activity and is used in the treatment of Lewis lung and colon tumors.
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XR 5944
XR5944, MLN 944, MLN-944, XR-5944, MLN944
T35187343247-32-5In house
XR 5944 is an antitumor compound that targets DNA, is a topoisomerase inhibitor, inhibits ER activity, and can be used to study colon and lung cancer.
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6-8 weeks
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5-ALA benzyl ester hydrochloride
Benzyl-ALA hydrochloride
T19147163271-32-7In house
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. It induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines.
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6-8 weeks
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