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  • Inhibitors & Agonists
    381
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    TargetMol | Inhibitors_Agonists
D-Tagatose
d-tagatos, D-(-)-Tagatose
T472387-81-0
D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose and isomer of D-galactose, occurs naturally in Sterculia setigera gum and is found in small quantities in various foods such as sterilized and powdered cow's milk, hot cocoa, and various cheeses, yogurts, and other dairy products. It can be synthesized from D-galactose by isomerization under alkaline conditions in the presence of calcium. D-Tagatose has numerous health benefits, including promotion of weight loss, no glycemic effect, anti-plaque, non-cariogenic, anti-halitosis, prebiotic, and anti-biofilm properties; it is beneficial for organ transplants, enhancement of flavor, improvement of pregnancy and fetal development, treatment of obesity, and reduction in symptoms associated with type 2 diabetes, hyperglycemia, anemia, and hemophilia. (PMID: 17492284).
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Pinostilbene
T375542438-89-1
Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.
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Indole-3-pyruvic acid
3-(3-Indolyl)-2-oxopropanoic acid
T4939392-12-1
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.
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Acolonifloroside K
T1245266251-64-5
Acolonifloroside K is a useful organic compound for research related to life sciences. The catalog number is T124526 and the CAS number is 6251-64-5.
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Curcolone
T125611
Curcolone is a useful organic compound for research related to life sciences and the catalog number is T125611.
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Curcolonol
TN3731217817-09-9
Curcolonol is a natural product of Curcuma, Zingiberaceae. The catalog number is TN3731 and the CAS number is 217817-09-9. Curcolonol can be used as a reference standard.
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Secolongifolenediol
TN498253587-37-4
Secolongifolenediol is a natural product for research related to life sciences. The catalog number is TN4982 and the CAS number is 53587-37-4.
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Antroquinonol
T300871010081-09-0In house
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segmental glomerulosclerosis through enhancement of the Nrf2 signaling pathway.Antroquinonol has potential for use in the treatment of non-small cell lung cancer. Antroquinonol has potential for the treatment of non-small cell lung cancer and may be used in colon cancer research.
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6-8weeks
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Vinaxanthone
SM-345431
T70955133293-89-7In house
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
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8-10 weeks
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3-Hydroxy-4-methoxyacetophenone
Acetoisovanillone
T101126100-74-9
3-Hydroxy-4-methoxyacetophenone (Acetoisovanillone) is an active P. spinosa extract. It possesses anti-inflammatory activity and prevented injuries due to administration of acetic acid in the colon.
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Silibinin
Silymarin I, Silybin, Silibinin A
T166022888-70-6
Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
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2'-Deoxyinosine
Guanine deoxyriboside
T1709890-38-0
2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency.
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L-Aspartic aicd sodium
Sodium L-aspartate, L-Aspartic acid sodium
T195543792-50-5
L-Aspartic aicd sodium (Sodium L-aspartate) is an amino acid, a precursor active molecule for colon-specific active molecule delivery, that promotes Na+ efflux from rat forebrain membrane vesicles.
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7-10 days
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Folinic acid
Leucovorin, HSDB 6544
T2440358-05-9
Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
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7-10 days
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Norcantharidin
Norcantharadine, Endothall anhydride
T28945442-12-6
Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
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3'-Hydroxypterostilbene
3'-HPT
T2S2382475231-21-1
3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK , and PI3K Akt mTOR p70S6K pathways and activates the ERK1 2, JNK1 2 MAPK pathways[1].
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Sophoridine
Dihydro-5-episophocarpine, 5-Epidihydrosophocarpine
T33396882-68-4
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
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(±)-Norcantharidin
Endothall anhydride, Norcantharidin
T565629745-04-8
(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
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kaempferide
Kaempferol 4'-O-methyl ether, Kaempferol 4'-methyl ether, 4'-Methylkaempferol, 4'-O-Methylkaempferol
T3806491-54-3
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.
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Rotundic acid
Rutundic acid
T5S050620137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.
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Ganoderic acid D
T5S1133108340-60-9
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 + - .3 microM.
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Rosmanol
T703380225-53-2
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induce
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Pedaliin
Pedalin, Pedalitin 6-O-glucoside, Glucosyl-6-pedalitin
TN554622860-72-6
Pedaliin is a flavonoid extracted from the above-ground parts of sesame (Sesamum indicum L) and the Tibetan medicine Dracocephalum tanguticum Maxim.Pedaliin has shown antioxidant and anticancer effects against colon cancer in vitro, and can be used in the study of cardiovascular diseases.
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2-Hydroxy-3-methoxy chalcone
TN72267146-86-3
2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
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