c 14

G0-C14 HCl is the salt form of G0-C14, a cationic lipid molecule and amphiphilic dendritic macromolecule commonly used in the synthesis of nanoparticles and vaccine delivery.

Pomalidomide-5-C14-NH2 hydrochloride is based on pomalidomide and acts as an E3 ubiquitin ligase cereblon (CRBN) ligand, which is utilized to recruit cereblon proteins. It can attach to protein ligands through a linker to form PROTAC.

N-(3-Oxotetradecanoyl)-DL-homoserine lactone, part of the N-Acyl homoserine lactone (AHL) family derived from gram-negative bacteria, serves as a quorum sensing (QS) signaling molecule.

G0-C14 is a cationic lipid-like molecule commonly used for synthesizing nanoparticles and vaccine delivery.

Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1].

Thalidomide-4-O-C14-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, through the attachment of a linker, can be utilized to create PROTACs [1].

IMCTA-C14, a detergent and derivative of the microbial metabolite 4-trehalosamine, exhibits a critical micelle concentration (CMC) of 0.11 mM and a hydrophilic-lipophilic balance (HLB) value of 9.72. It effectively extracts proteins, including membrane proteins, from OVK18 ovarian cancer cells at concentrations of 0.05 and 0.5%. Furthermore, IMCTA-C14 demonstrates antibacterial activity against various bacterial strains (MICs = 8-128 µg/ml) and shows cytotoxicity against a spectrum of 52 cancer cell lines (IC50s = 2.9-29.2 µg/ml). At a concentration of 50 µM, it induces autophagy in OVK18 cells.

C14-4 (C14-494) is an ionizable lipid nanoparticle used for delivering CAR mRNA to primary human T cells.

Sphingomyelin (d18:1,C14:0) is a principal sphingolipid found in mammalian cells that enhances the molecular order of cell membranes.

C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).

C14 Glucosyl(β) ceramide (d18:1/14:0) is a β-glucosylceramide.

C14 Galactosyl(β) ceramide (d18:1/14:0) is a β-galactosylceramide.

C14:1 L-Carnitine chloride is an acylcarnitine lipid.

CB1 receptor inverse agonist

Boc-C14-COOH is a alkyl-chain-based PROTAC linker. Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

BAMB-4 (ITPKA-IN-C14) is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA), effectively suppressing the metastasis-promoting effect of ITPKA in lung tumor cells (with IC50 of 37 μM in ADP-Glo Assay).

Orotic acid-6-C14 is an endogenous metabolite. [PubChem]

Tipranavir C-14 is an antiretroviral protease inhibitor primarily used for the treatment and prevention of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS).

C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's research.

C14-A1 is an ionizable cationic lipid utilized in the synthesis of lipid nanoparticles (LNP), which are employed for delivering mRNA and various other payloads.

C14-O2 is an ionizable cationic lipid utilized in the synthesis of lipid nanoparticles (LNP) for the delivery of mRNA and other payloads.

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria.[1] [2] [3] It appears later than shorter acyl chain AHLs in developing biofilms [4] and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, [5] which in turn, inhibits biofilm formation.

N-tetradecanoyl-L-homoserine lactone is a long-chain N-acyl homoserine lactone (AHL) and bacterial quorum sensing signal molecule that promotes diatom growth and upregulates genes involved in intracellular signalling.

Δ7(Z)-C14-HSL (Compound 12), an immunosuppressive agent, inhibits the proliferation of mouse splenic cells, exhibiting an IC 50 of 17 μM. It holds promise for exploring its role as a molecular mechanism in TNF-R-driven immune diseases, including autoimmune disorders like psoriasis, rheumatoid arthritis, and type 1 diabetes [1].