Search Result

Search Results for " metastatic "

Targets

NF-κB

131

Compounds

Natural Products

128

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T9582	CLEFMA		NF-κB
	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.		NF-κB
T8217	Enzalutamide carboxylic acid		Androgen Receptor , Drug Metabolite
	Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .		Androgen Receptor , Drug Metabolite
T8310	MMP-9-IN-1		MMP
	MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).		MMP
T10297L	AMG 487		CXCR
	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.		CXCR
T12695	RBN-2397		PARP
	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.		PARP
T22263	Bavdegalutamide	ARV-110	Androgen Receptor
	Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...		Androgen Receptor
T1855	ZCL278	ZCL 278	CDK , Ras
	ZCL278 is a selective Cdc42 GTPase inhibitor.		CDK , Ras
T27730	KGP94	KGP-94,KGP 94	Cysteine Protease
	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).		Cysteine Protease
T1120	Dacarbazine	Imidazole Carboxamide,DTIC-Dome	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
T5125	LY3200882		TGF-beta/Smad
	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).		TGF-beta/Smad
T8327	ONO-7475		Trk receptor , TAM Receptor
	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase		Trk receptor , TAM Receptor
T22450	Tyrphostin B44, (+) enantiomer		EGFR
	Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.		EGFR
T13687	Eribulin mesylate	B1939 mesylate,ER-086526 mesylate,E7389 mesylate	Apoptosis , Others , Microtubule Associated
	Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is...		Apoptosis , Others , Microtubule Associated
T35300	Zeniplatin	Zeniplatinum	Others
	Zeniplatin (Zeniplatinum) is a new cisplatin complex with anticancer activity for the treatment of metastatic melanoma and kidney cancer.		Others
T17255	WJ460		Others
	WJ460 is an effective inhibitor of myoferlin. WJ460 exerts anti-metastatic activity in breast cancer cells.		Others
T27319	FIIN-4	FIIN4	FGFR
	FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.		FGFR
T9236	WSB1 Degrader 1		Others , E1/E2/E3 Enzyme
	WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.		Others , E1/E2/E3 Enzyme
T9075	BDP-13176		Others
	BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent		Others
T62536	S100P-IN-1		Others
	S100P-IN-1 is a potent S100P inhibitor.S100P-IN-1 has anti-metastatic effects on pancreatic cancer (pancreatic) cells.		Others
T21808	Inotilone		Others
	Inotilone is a major component of Inonotus linteus, a traditional Chinese medical herb and can be used for research of metastatic lung cancer cells.		Others
T12433	PF-06952229	PF06952229	TGF-beta/Smad
	PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.		TGF-beta/Smad
T22136	PRL-3 Inhibitor I	PRL-3 Inhibitor,BR-1	Phosphatase , Others
	PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.		Phosphatase , Others
T39403	Avotaciclib	BEY1107,Avotaciclib	CDK
	Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastatic pancreatic cancer.		CDK
T2113	PHA-793887	PHA 793887,PHA793887	Apoptosis , CDK
	PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.		Apoptosis , CDK
T24644	Piritrexim	BW 301U	DHFR
	Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma and metastatic breast cancer.		DHFR
T26969	CCT365623	CCT-365623,CCT 365623	Monoamine Oxidase
	CCT365623 is an orally bioavailable Lysyl Oxidase inhibitor with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.		Monoamine Oxidase
T6215	Abiraterone Acetate	Zytiga,CB7630	P450
	Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.		P450
T4022	QS11	QS 11	GTPase
	QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r...		GTPase
T77138	Ragifilimab	INCAGN-01876,INCAGN-1876,CM-701	TNF
	Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study of advanced or metastatic solid tumors.		TNF
T9912	Trastuzumab		EGFR
	Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastr...		EGFR
T76866	Icrucumab	LY 3012212,IMC-18F1	VEGFR
	Icrucumab ( IMC-18F1) is a humanized IgG1 monoclonal antibody targeting vascular endothelial growth factor receptor-1.Icrucumab has antitumor activity.Icrucumab has been studied in metastatic colon cancer.		VEGFR
T3710	XMD16-5		Tyrosinase , PPAR
	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is d...		Tyrosinase , PPAR
T2618	LGK974	LGK 974,LGK-974,NVP-LGK974,WNT974	Porcupine
	LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...		Porcupine
T2381	Abemaciclib	CDK4/6 dual inhibitor,LY2835219	CDK
	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.		CDK
T2357	GSK1059615	GSK 1059615,GSK-1059615	Apoptosis , PI3K , mTOR
	GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.		Apoptosis , PI3K , mTOR
T39044	Rezvilutamide	SHR3680	Androgen Receptor
	Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Rezvilutamide (SHR3680) is used in the study of metastatic desmoplasia-resistant ...		Androgen Receptor
T0078	Lapatinib	GSK572016,GW572016	EGFR , Ferroptosis , Autophagy
	Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced or metastatic breast cancer with HER2 overexpression.		EGFR , Ferroptosis , Autophagy
T77374	Ontuxizumab	MORAb-004	Others
	Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 or CD248) monoclonal antibody for the treatment of metastatic mela...		Others
T76857	Anetumab		Others
	Anetumab is a novel fully human anti-mesothelin IgG1 antibody that is a naked antibody to Anetumab ravtansine.Anetumab can be used to synthesize the antibody-activated molecule coupling, Anetumab ravtansine.Anetumab can ...		Others
T76828	Sonepcizumab	LT 1009	LPL Receptor
	Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi...		LPL Receptor
T29214	ZEN-3694	ZEN 3694,ZEN3694	Epigenetic Reader Domain
	ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and can be used in combination with enzalutamide to study metastatic ...		Epigenetic Reader Domain
T77149	Cobolimab	TSR-022,GSK4069889	Others
	Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic mela...		Others
T76750	Cemiplimab	REGN-2810,SAR-439684	Others
	Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance...		Others
T76890	Petosemtamab	MCLA 158	EGFR
	Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab...		EGFR
T17228	Sabizabulin	ABI-231,VERU-111	Microtubule Associated
	Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervica...		Microtubule Associated
T63505	Tivozanib hydrochloride hydrate
	Tivozanib hydrochloride hydrate is a selective, potent, orally active VEGFR tyrosine kinase inhibitor that acts on VEGFR-1 (IC50: 0.21 nM), VEGFR-2 (IC50: 0.16 nM), and VEGFR-3 (IC50: 0.24 nM). Tivozanib hydrochloride hy...
T2283	PX-12	IV-2,PX12	Thioredoxin
	PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...		Thioredoxin
T60616	MPT0G211		HDAC
	MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinit...		HDAC
TP1565L1	Foxy-5 Ammonium Salt	Foxy-5 Ammonium Salt（881188-51-8 Free base)	Wnt/beta-catenin
	Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and in...		Wnt/beta-catenin

Compounds

Enzalutamide carboxylic acid

T8217

Synonym:

Target: Androgen Receptor, Drug Metabolite

Target: Androgen Receptor

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

Dacarbazine

T1120

Synonym: Imidazole Carboxamide,DTIC-Dome

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Metarrestin

T12006

Synonym: ML246

Target: DNA/RNA Synthesis

LY3200882

T5125

Synonym:

Target: TGF-beta/Smad

ONO-7475

T8327

Synonym:

Target: Trk receptor, TAM Receptor

Tyrphostin B44, (+) enantiomer

Synonym: B1939 mesylate,ER-086526 mesylate,E7389 mesylate

Target: Apoptosis, Others, Microtubule Associated

Zeniplatin

T35300

Synonym: Zeniplatinum

Target: Others, E1/E2/E3 Enzyme

Target: TGF-beta/Smad

PRL-3 Inhibitor I

T22136

Synonym: PRL-3 Inhibitor,BR-1

Target: Phosphatase, Others

Avotaciclib

T39403

Synonym: BEY1107,Avotaciclib

Target: CDK

PHA-793887

T2113

Synonym: PHA 793887,PHA793887

Target: Apoptosis, CDK

Synonym: CCT-365623,CCT 365623

Target: Monoamine Oxidase

Abiraterone Acetate

T6215

Synonym: Zytiga,CB7630

Synonym: INCAGN-01876,INCAGN-1876,CM-701

Synonym: LY 3012212,IMC-18F1

Target: Tyrosinase, PPAR

LGK974

T2618

Synonym: LGK 974,LGK-974,NVP-LGK974,WNT974

Target: Porcupine

Abemaciclib

T2381

Synonym: CDK4/6 dual inhibitor,LY2835219

Target: CDK

GSK1059615

T2357

Synonym: GSK 1059615,GSK-1059615

Target: Apoptosis, PI3K, mTOR

Rezvilutamide

T39044

Synonym: SHR3680

Target: Androgen Receptor

Lapatinib

T0078

Synonym: GSK572016,GW572016

Target: EGFR, Ferroptosis, Autophagy

Synonym: ZEN 3694,ZEN3694

Target: Epigenetic Reader Domain

Cobolimab

T77149

Synonym: TSR-022,GSK4069889

Target: Others

Cemiplimab

T76750

Synonym: REGN-2810,SAR-439684

Synonym: ABI-231,VERU-111

Target: Microtubule Associated

Tivozanib hydrochloride hydrate

Synonym: Foxy-5 Ammonium Salt（881188-51-8 Free base)

Target: Wnt/beta-catenin

Cat No.	Product Name	Synonyms	Targets
T1135	Vitamin D3	Cholecalciferol,Colecalciferol	Endogenous Metabolite
	Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR).		Endogenous Metabolite
T5S0803	Columbamine	Columbamin,Dehydroisocorypalmine	Others
	Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.		Others
T2543	Cabazitaxel	XRP6258,RPR-116258A,TXD 258,taxoid XRP6258	Microtubule Associated , Autophagy
	Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.		Microtubule Associated , Autophagy
T7927	β-Ionone	β-lonone	Apoptosis , Others
	β-Ionone (β-lonone) is an end-ring analog of β-carotenoids which widely distributed in fruit and vegetables,with anti-proliferative, anti-metastatic		Apoptosis , Others
T20578	Maclurin	Fustic extract,Morintannic acid,NSC 83240	Free radical scavengers , Reactive Oxygen Species
	Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of ...		Free radical scavengers , Reactive Oxygen Species
T1082	Benzyl isothiocyanate	Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester	Apoptosis , Antibacterial , Antibiotic
	Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog...		Apoptosis , Antibacterial , Antibiotic
T13741	Isoviolanthin		Others
	Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...		Others
T2P2923	Stearic acid	Isostearic acid,Octadecanoic acid,Cetylacetic acid	Phosphatase , Endogenous Metabolite
	1. Stearic acid (Cetylacetic acid) can reduce metastatic tumor burden. 2. Stearic acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. 3. Stearic acid and its derivatives have...		Phosphatase , Endogenous Metabolite
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T6S1369	Vitexin	Apigenin-8-C-glucoside	Antioxidant
	1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit...		Antioxidant
T5S0053	Coptisine	Coptisin	Indoleamine 2,3-Dioxygenase (IDO)
	1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...		Indoleamine 2,3-Dioxygenase (IDO)
TN1867	Licoricidin		MMP , VEGFR , ROS
	Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.		MMP , VEGFR , ROS
T13472	α-Carotene		Others
	α-Carotene is isolated from yellow-orange and dark-green vegetables. α-Carotene is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.		Others
TN3517	Bisacurone		IL Receptor , IκB/IKK , TNF , NF-κB , ROS , Akt , PKC
	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation.		IL Receptor , IκB/IKK , TNF , NF-κB , ROS , Akt , PKC
TN1062	Peonidin chloride		ERK , COX
	Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast cancer cells.		ERK , COX
TN4352	Jatamanvaltrate B		Others
	Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.		Others
TN2813	23-deoxojessic acid		Others
	23-Deoxojessic acid possesses strong cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, with ED50 values equal to or less than 6 microM.		Others
T16035	Meleagrin		Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast mali...		Others
TN4101	Ganoderenic acid H		Others
	Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic act...		Others
TN3646	Chlorovaltrate K		Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.		Others
TN5249	Volvaltrate B		Others
	Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, r...		Others
TN4046	Excisanin A		MMP , FAK , PARP , GSK-3 , NF-κB , Wnt/beta-catenin , Akt , Caspase , PI3K , Prostaglandin Receptor , JNK
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatm...
T40960	Fibronectin		Integrin
	Fibronectin is a macromolecular glycoprotein found in blood, connective tissue, and cell surfaces that serves as a biomarker for tissue damage.Fibronectin is recognized by the integrin family of surface receptors.Fibrone...		Integrin
T37055	Cytostatin
	Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix. Cytostatin selectively inhibits protein Phosphatase 2A.

Natural Products

Vitamin D3

T1135

Synonym: Cholecalciferol,Colecalciferol

Target: Endogenous Metabolite

Columbamine

T5S0803

Synonym: Columbamin,Dehydroisocorypalmine

Target: Others

Cabazitaxel

T2543

Synonym: XRP6258,RPR-116258A,TXD 258,taxoid XRP6258

Target: Microtubule Associated, Autophagy

β-Ionone

T7927

Synonym: β-lonone

Target: Apoptosis, Others

Maclurin

T20578

Synonym: Fustic extract,Morintannic acid,NSC 83240

Target: Free radical scavengers, Reactive Oxygen Species

Benzyl isothiocyanate

T1082

Synonym: Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

Synonym: Isostearic acid,Octadecanoic acid,Cetylacetic acid

Target: Phosphatase, Endogenous Metabolite

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Vitexin

T6S1369

Synonym: Apigenin-8-C-glucoside

Target: Indoleamine 2,3-Dioxygenase (IDO)

Licoricidin

TN1867

Synonym:

Target: MMP, VEGFR, ROS

Target: IL Receptor, IκB/IKK, TNF, NF-κB, ROS, Akt, PKC

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPJ-00776	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPJ-00777	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPY-02030	CD82 Protein, Human, Recombinant (His)	Human	HEK293
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras...
TMPY-01859	LYPD3 Protein, Human, Recombinant (His)	Human	HEK293
	Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, and LYPD3, is a cell membrane protein that contains two UPAR/Ly6 ...
TMPY-01884	MMP-8 Protein, Human, Recombinant	Human	HEK293
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPY-04722	DcR1/TRAILR3 Protein, Human, Recombinant (His)	Human	HEK293
	TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most ...
TMPY-01601	AXL Protein, Human, Recombinant (His)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His)	Human	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-06418	R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)	Human	HEK293
	R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene...
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-00381	PSMA Protein, Human, Recombinant (His)	Human	HEK293
	Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane prote...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His)	Human	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-02785	Tetranectin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tetranectin (TN), also known as C-type lectin domain family 3, member B (CLEC3B) is a member of the C-type lectin Family. It is plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes v...
TMPY-01143	N Cadherin Protein, Human, Recombinant (His)	Human	HEK293
	Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a sin...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPY-03016	CD24 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00876	Legumain Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The Mammalian Legumain, also known as LGMN, also called asparaginyl endopeptidase (AEP), is a cysteine protease belonging to peptidase family C13 with strict specificity for hydrolysis of asparaginyl bonds. Known previou...
TMPY-01730	CD24 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05588	EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell ...
TMPK-01299	CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)	Cynomolgus	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at meta...
TMPY-03876	PTGFRN Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT. EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP rece...
TMPK-01181	CDCP1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-01256	CDCP1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-01255	CDCP1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated	Cynomolgus	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-01182	CDCP1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-01010	CDCP1 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-01183	CDCP1 Protein, Human, Recombinant (aa 30-368, His)	Human	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPK-00635	CDCP1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss ...
TMPJ-00911	GUCY2C Protein, Human, Recombinant (hFc)	Human	Human Cells
	GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPJ-00910	GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPY-01122	CGB5 Protein, Human, Recombinant (mFc)	Human	HEK293
	The human CGB5 gene encodes chorionic gonadotropin (hCG)beta 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiati...
TMPK-01284	Syndecan-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00593	Syndecan-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPY-02622	Aldolase B Protein, Human, Recombinant (GST)	Human	E. coli
	The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed...
TMPK-00595	Syndecan-1 Protein, Human, Recombinant (aa 23-254, His)	Human	HEK293
	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPY-03982	CGB5 Protein, Human, Recombinant (His)	Human	HEK293
	The human CGB5 gene encodes chorionic gonadotropin (hCG)beta 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiati...
TMPK-00594	Syndecan-1 Protein, Human, Recombinant (aa 23-254, hFc)	Human	HEK293
	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00201	Syndecan-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00728	PSCA Protein, Human, Recombinant (hFc)	Human	HEK293
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell s...
TMPJ-00399	AXL Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPY-01810	LYPD3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, and LYPD3, is a cell membrane protein that contains two UPAR/Ly6 ...
TMPK-00906	PSCA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell s...
TMPJ-00449	AXL Protein, Human, Recombinant (hFc)	Human	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPY-05250	CLEC3A Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicate...
TMPK-01072	AMIGO2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BE...
TMPY-01844	MMP-8 Protein, Mouse, Recombinant	Mouse	HEK293
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPY-01377	MMP-8 Protein, Human, Recombinant (His)	Human	HEK293
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
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HER2/ERBB2 Protein, Human, Recombinant (His)

TMPJ-00778

Species: Human

Expression System: Human Cells

HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

TMPJ-00776

Species: Human

Expression System: Human Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)

TMPJ-00777

Species: Human

Expression System: Human Cells

CD82 Protein, Human, Recombinant (His)

TMPY-02030

Species: Human

Expression System: HEK293

LYPD3 Protein, Human, Recombinant (His)

TMPY-01859

Species: Human

Expression System: HEK293

MMP-8 Protein, Human, Recombinant

TMPY-01884

Species: Human

Expression System: HEK293

DcR1/TRAILR3 Protein, Human, Recombinant (His)

TMPY-04722

Species: Human

Expression System: HEK293

AXL Protein, Human, Recombinant (His)

TMPY-01601

Species: Human

Expression System: HEK293

HGFR/c-Met Protein, Mouse, Recombinant (His)

TMPY-01896

Species: Mouse

Expression System: HEK293

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293

HGFR/c-Met Protein, Human, Recombinant (His)

TMPY-01296

Species: Human

Expression System: HEK293

R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)

TMPY-06418

Species: Human

Expression System: HEK293

Periostin/OSF-2 Protein, Mouse, Recombinant (His)

TMPY-01613

Species: Mouse

Expression System: HEK293

PSMA Protein, Human, Recombinant (His)

TMPY-00381

Species: Human

Expression System: HEK293

Periostin/OSF-2 Protein, Human, Recombinant (His)

TMPY-01020

Species: Human

Expression System: HEK293

Tetranectin Protein, Mouse, Recombinant (His)

TMPY-02785

Species: Mouse

Expression System: HEK293

N Cadherin Protein, Human, Recombinant (His)

TMPY-01143

Species: Human

Expression System: HEK293

GAS6 Protein, Mouse, Recombinant (His)

TMPY-04830

Species: Mouse

Expression System: HEK293

CD24 Protein, Mouse, Recombinant (hFc)

TMPY-03016

Species: Mouse

Expression System: HEK293

Legumain Protein, Mouse, Recombinant (His)

TMPY-00876

Species: Mouse

Expression System: HEK293

CD24 Protein, Human, Recombinant (hFc)

TMPY-01730

Species: Human

Expression System: HEK293

EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-05588

Species: Human

Expression System: HEK293

CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)

TMPK-01299

Species: Cynomolgus

Expression System: HEK293

PTGFRN Protein, Cynomolgus, Recombinant (His)

TMPY-03876

Species: Cynomolgus

Expression System: HEK293

CDCP1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-01181

Species: Human

Expression System: HEK293

CDCP1 Protein, Cynomolgus, Recombinant (His)

TMPK-01256

Species: Cynomolgus

Expression System: HEK293

CDCP1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

TMPK-01255

Species: Cynomolgus

Expression System: HEK293

CDCP1 Protein, Human, Recombinant (hFc)

TMPK-01182

Species: Human

Expression System: HEK293

CDCP1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

TMPK-01010

Species: Mouse

Expression System: HEK293

CDCP1 Protein, Human, Recombinant (aa 30-368, His)

TMPK-01183

Species: Human

Expression System: HEK293

CDCP1 Protein, Rat, Recombinant (His)

TMPK-00635

Species: Rat

Expression System: HEK293

GUCY2C Protein, Human, Recombinant (hFc)

TMPJ-00911

Species: Human

Expression System: Human Cells

GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00910

Species: Human

Expression System: Human Cells

CGB5 Protein, Human, Recombinant (mFc)

TMPY-01122

Species: Human

Expression System: HEK293

Syndecan-1 Protein, Cynomolgus, Recombinant (His)

TMPK-01284

Species: Cynomolgus

Expression System: HEK293

Syndecan-1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00593

Species: Human

Expression System: HEK293

Aldolase B Protein, Human, Recombinant (GST)

TMPY-02622

Species: Human

Expression System: E. coli

Syndecan-1 Protein, Human, Recombinant (aa 23-254, His)

TMPK-00595

Species: Human

Expression System: HEK293

CGB5 Protein, Human, Recombinant (His)

TMPY-03982

Species: Human

Expression System: HEK293

Syndecan-1 Protein, Human, Recombinant (aa 23-254, hFc)

TMPK-00594

Species: Human

Expression System: HEK293

Syndecan-1 Protein, Mouse, Recombinant (hFc)

TMPK-00201

Species: Mouse

Expression System: HEK293

PSCA Protein, Human, Recombinant (hFc)

TMPK-00728

Species: Human

Expression System: HEK293

AXL Protein, Mouse, Recombinant (hFc)

TMPJ-00399

Species: Mouse

Expression System: Human Cells

LYPD3 Protein, Mouse, Recombinant (His)

TMPY-01810

Species: Mouse

Expression System: HEK293

PSCA Protein, Mouse, Recombinant (hFc)

TMPK-00906

Species: Mouse

Expression System: HEK293

AXL Protein, Human, Recombinant (hFc)

TMPJ-00449

Species: Human

Expression System: Human Cells

CLEC3A Protein, Mouse, Recombinant (His)

TMPY-05250

Species: Mouse

Expression System: Baculovirus-Insect Cells

AMIGO2 Protein, Mouse, Recombinant (His)

TMPK-01072

Species: Mouse

Expression System: HEK293

MMP-8 Protein, Mouse, Recombinant

TMPY-01844

Species: Mouse

Expression System: HEK293

MMP-8 Protein, Human, Recombinant (His)

TMPY-01377

Species: Human

Expression System: HEK293

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Cat No.	Product Name
L2194	Anti-Colorectal Cancer Compound Library	1565 compounds
	1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L2196	Anti-Ovarian Cancer Compound Library	1888 compounds
	A unique collection of 1888 compounds with anti-ovarian cancer therapeutic activity, can be used for anti-ovarian cancer drug discovery and pharmacological study;

Libraries

Anti-Colorectal Cancer Compound Library

L2194

Compounds: 1565

Anti-Ovarian Cancer Compound Library

L2196

Compounds: 1888