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Results for "

Microtubule Associated

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    202
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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    TargetMol | Peptide_Products
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    TargetMol | Inhibitory_Antibodies
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Paclitaxel
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
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TargetMol | Inhibitor Hot
Eribulin mesylate
ER-086526 mesylate, E7389 mesylate, B1939 mesylate
T13687441045-17-6
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer.
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TargetMol | Inhibitor Hot
Maytansinol
Ansamitocin P-0
T1601657103-68-1
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
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TargetMol | Inhibitor Hot
c004019
T678342417159-57-8In house
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
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8-10 weeks
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TargetMol | Inhibitor Hot
CCB02
T107042100864-57-9In house
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
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6-8 weeks
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Sabeluzole
R-58735, R58735, R 58735
T28655104383-17-7In house
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be useful in the study of Alzheimer's disease.
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6-8 weeks
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AC 7739
T71924L162705-22-8In house
AC 7739 is a microtubule protein binding agent with anticancer and antitumor activity that inhibits advanced solid tumors and in situ transplanted tumors.
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Methylene Blue trihydrate
Methylthionine chloride, Methylene Blue, Basic blue 9
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
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Docetaxel trihydrate
RP-56976 (Trihydrate), RP56976 (NSC 628503) Trihydrate
T0186148408-66-6
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor including breast and lung cancer. Therapy with docetaxel has been associated with a low rate of serum enzyme elevations and rarely to instances of acute hepatic necrosis generally due to severe hypersensitivity reactions or sepsis.
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4-6 weeks
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Colchicine
Colcin, Colchisol, Colchineos
T032064-86-8
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of ventilation and rheumatic diseases.
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Thiabendazole
2-(4-Thiazolyl)benzimidazole
T0938148-79-8
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
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Docetaxel
RP-56976, NSC 628503
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
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Albendazole
SKF-62979
T115254965-21-8
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
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Mebendazole
Vermox, Telmin, Pantelmin, Mebenvet
T115531431-39-7
Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.
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4-Isopropoxybenzoic acid
AI3-12104, AI312104, AI3 12104
T2497713205-46-4
4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.
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TargetMol | Inhibitor Sale
Combretastatin A4
CRC 87-09, CA4
T6212117048-59-6
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
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Vincristine sulfate
Leurocristine sulfate, Leurocristine, 22-Oxovincaleukoblastine sulfate
T12702068-78-2
Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.
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Mertansine
Maytansinoid DM1, DM1
T1992139504-50-0
Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.
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Nocodazole
R17934, Oncodazole
T280231430-18-9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
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Vinorelbine ditartrate
Vinorelbine Tartrate, Nor-5'-anhydrovinblastine ditartrate, Navelbine tartrate, KW-2307
T6213125317-39-7
Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity, inhibiting cell proliferation and inducing apoptosis.
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TargetMol | Inhibitor Hot
Fosbretabulin Disodium
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, Combretastatin A4 Phosphate, Combretastatin A4 disodium phosphate, CA 4P, CA 4DP
T6272168555-66-6
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
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Monomethyl auristatin E
Vedotin, MMAE
T6897474645-27-7
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
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TargetMol
Eribulin
ER-086526, E7389, B1939
T13688253128-41-5
Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
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7-10 days
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Auristatin F
T14349163768-50-1
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
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4-6 weeks
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TargetMol | Inhibitor Sale