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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Cat. No. Product name CAS No. Purity Chemical Structure
T12044 (-)-Bicuculline methochloride 53552-05-9 98%
(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.
TN4298 Isohyenanchin 19417-00-6 98%
Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors.
TN3868 Dihydroxyaflavinine 76410-56-5 98%
Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity ...
T4655 Pipequaline 77472-98-1 98%
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure t...
TN1591 DL-Menthol 15356-70-4 98%
DL-Menthol has short term toxicity in rats, it plays a role in the induction of surgical anesthesia in fishes, related at least in part to the activation of GABA...
TN3702 (-)-Corlumine 79082-64-7 98%
Corlumine exhibits spasmolytic and GABA antagonist activity.
T0128L Vigabatrin Hydrochloride 1391054-02-6 98%
Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA t...
T4S1616 Sanggenon D 81422-93-7 98%
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflamma...
T17306 (R)-Baclofen hydrochloride 63701-55-3 98%
Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to...
TQ0151 L-655708 130477-52-0 98%
L-655708 is an effective inverse agonist of the α5 subunit-selective GABAA receptor (Ki: 0.45 nM).
T11350 GABAB receptor antagonist 1 797-17-1 98%
(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective an...
T12867 SCH 50911 hydrochloride 160415-07-6 98%
SCH 50911 hydrochloride is a selective, orally-active and competitive antagonist of γ-Aminobutyric acid B GABA(B) receptor(IC50 : 1.1 μM).
TN1842 Kushenol I 99119-69-4 98%
Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be activ...
T10869L CP-409092 194098-25-4 98%
CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.
TN4322 Isopulegol 7786-67-6 98%
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly re...
T10456 Bamaluzole 87034-87-5 98%
Bamaluzole is an agonist of GABA receptor extracted from patent WO 2012064642 A1.
T15737 Lesogaberan 344413-67-8 98%
Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, t...
TN4440 Limonexic acid 99026-99-0 98%
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively prote...
T17215 Valnoctamide 4171-13-5 98%
Valnoctamide inhibits benzodiazepine-refractory status epilepticus. Valnoctamide acts directly on GABAA receptors.
T12867L SCH 50911 733717-87-8 98%
SCH 50911 is (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid and is a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, b...
(-)-Bicuculline methochloride
T12044
(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.
Isohyenanchin
TN4298
Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors.
Dihydroxyaflavinine
TN3868
Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity ...
Pipequaline
T4655
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure t...
DL-Menthol
TN1591
DL-Menthol has short term toxicity in rats, it plays a role in the induction of surgical anesthesia in fishes, related at least in part to the activation of GABA...
(-)-Corlumine
TN3702
Corlumine exhibits spasmolytic and GABA antagonist activity.
Vigabatrin Hydrochloride
T0128L
Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly inhibits the catabolism of GABA by GABA t...
Sanggenon D
T4S1616
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflamma...
(R)-Baclofen hydrochloride
T17306
Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to...
L-655708
TQ0151
L-655708 is an effective inverse agonist of the α5 subunit-selective GABAA receptor (Ki: 0.45 nM).
GABAB receptor antagonist 1
T11350
(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective an...
SCH 50911 hydrochloride
T12867
SCH 50911 hydrochloride is a selective, orally-active and competitive antagonist of γ-Aminobutyric acid B GABA(B) receptor(IC50 : 1.1 μM).
Kushenol I
TN1842
Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be activ...
CP-409092
T10869L
CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.
Isopulegol
TN4322
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly re...
Bamaluzole
T10456
Bamaluzole is an agonist of GABA receptor extracted from patent WO 2012064642 A1.
Lesogaberan
T15737
Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, t...
Limonexic acid
TN4440
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively prote...
Valnoctamide
T17215
Valnoctamide inhibits benzodiazepine-refractory status epilepticus. Valnoctamide acts directly on GABAA receptors.
SCH 50911
T12867L
SCH 50911 is (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid and is a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, b...
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