c-14

Tipranavir C-14 is an antiretroviral protease inhibitor primarily used for the treatment and prevention of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS).

G0-C14 HCl is the salt form of G0-C14, a cationic lipid molecule and amphiphilic dendritic macromolecule commonly used in the synthesis of nanoparticles and vaccine delivery.

Boc-C14-COOH is a alkyl-chain-based PROTAC linker. Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

BAMB-4 (ITPKA-IN-C14) is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA), effectively suppressing the metastasis-promoting effect of ITPKA in lung tumor cells (with IC50 of 37 μM in ADP-Glo Assay).

C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's research.

Pomalidomide-5-C14-NH2 hydrochloride is based on pomalidomide and acts as an E3 ubiquitin ligase cereblon (CRBN) ligand, which is utilized to recruit cereblon proteins. It can attach to protein ligands through a linker to form PROTAC.

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria.[1] [2] [3] It appears later than shorter acyl chain AHLs in developing biofilms [4] and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, [5] which in turn, inhibits biofilm formation.

N-tetradecanoyl-L-homoserine lactone is a long-chain N-acyl homoserine lactone (AHL) and bacterial quorum sensing signal molecule that promotes diatom growth and upregulates genes involved in intracellular signalling.

N-(3-Oxotetradecanoyl)-DL-homoserine lactone, part of the N-Acyl homoserine lactone (AHL) family derived from gram-negative bacteria, serves as a quorum sensing (QS) signaling molecule.

G0-C14 is a cationic lipid-like molecule commonly used for synthesizing nanoparticles and vaccine delivery.

Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1].

Thalidomide-4-O-C14-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, through the attachment of a linker, can be utilized to create PROTACs [1].

IMCTA-C14, a detergent and derivative of the microbial metabolite 4-trehalosamine, exhibits a critical micelle concentration (CMC) of 0.11 mM and a hydrophilic-lipophilic balance (HLB) value of 9.72. It effectively extracts proteins, including membrane proteins, from OVK18 ovarian cancer cells at concentrations of 0.05 and 0.5%. Furthermore, IMCTA-C14 demonstrates antibacterial activity against various bacterial strains (MICs = 8-128 µg/ml) and shows cytotoxicity against a spectrum of 52 cancer cell lines (IC50s = 2.9-29.2 µg/ml). At a concentration of 50 µM, it induces autophagy in OVK18 cells.

C14-4 (C14-494) is an ionizable lipid nanoparticle used for delivering CAR mRNA to primary human T cells.

Sphingomyelin (d18:1,C14:0) is a principal sphingolipid found in mammalian cells that enhances the molecular order of cell membranes.

1,2,3-Trimyristoleoyl Glycerol (Standard) is the standard substance of 1,2,3-Trimyristoleoyl Glycerol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1,2,3-Trimyristoleoyl glycerol, a triacylglycerol featuring myristoleic acid at the sn-1, sn-2, and sn-3 positions, is detected in Idiazabal cheese.

Methyl myristate (Standard) is the standard substance of Methyl myristate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Methyl myristate (methyl tetradecanoate) is a natural product.

Myristic acid (Standard) is the standard substance of Myristic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.

Myristoleic acid (Standard) is the standard substance of Myristoleic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Myristoleic acid (9-Tetradecenoic acid) is a cytotoxic component in the extract from Serenoa repens. Myristoleic acid induces apoptosis and necrosis in human prostatic LNCaP cells.

Myristoleic Acid Methyl Ester (Standard) is the standard substance of Myristoleic Acid Methyl Ester, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Myristoleic Acid Methyl Ester is a natural product.

Trimyristin (Standard) is the standard substance of Trimyristin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Trimyristin (Tritetradecanoin) is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ranging from yeast to humans. In humans, glyceryl trimyristate is involved in the metabolic disorder called de novo triacylglycerol biosynthesis glyceryl trimyristate pathway.

Trehalose C14 is a surfactant.

C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).

C14 Glucosyl(β) ceramide (d18:1/14:0) is a β-glucosylceramide.