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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T31083 CP-868388 free base 702681-67-2 99.84%
CP-868388 free base
CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslip...
T3090 Abietic Acid 514-10-3 92.6%
Abietic Acid
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.
TWS0787 Oroxin A 31567-75-6
Oroxin A
Oroxin A (Baicalin-7-glucoside) is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhib...
TN3366 Ailanthoidol 156398-61-7 98%
Ailanthoidol
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
T15580 Inolitazone dihydrochloride 223132-38-5 98%
Inolitazone dihydrochloride
Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Ino...
T10505 PPARα-MO-1 810677-36-2 98%
PPARα-MO-1
PPARα-MO-1 is a potent modulator of PPARα.
T78806 PPARδ agonist 9 928023-21-6 98%
PPARδ agonist 9
PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic ...
T79129 CRX000227 686769-92-6 98%
CRX000227
CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].
T79182 PPARγ agonist 8 1049800-41-0 98%
PPARγ agonist 8
PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator respon...
T79231 DSO-5a 2195411-63-1 98%
DSO-5a
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. I...
T79454 Anti-NASH agent 1 2409685-41-0 98%
Anti-NASH agent 1
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages ...
T79678 PPARγ-IN-2 2682078-97-1 98%
PPARγ-IN-2
"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes. Furthermore, PPARγ-IN-2 counter...
T79949 Foenumoside B 877661-00-2 98%
Foenumoside B
Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes lipo...
T81120 SP4f 98%
SP4f
SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose levels and lipid peroxidation whi...
T81121 SP4e 98%
SP4e
SP4e, a PPAR-γ activator, exhibits an EC50 of 739 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose and lipid peroxidation while enhancing glut...
TN1681 Gentianine 439-89-4 98%
Gentianine
Gentianine is an effective Swertiamarin derivative, which has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, diuretic and other effects, and has t...
T15336 Fonadelpar 515138-06-4 98%
Fonadelpar
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
TN4390 Kihadanin B 73793-68-7 98%
Kihadanin B
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN3219 7,8-Didehydrocimigenol 150972-72-8 98%
7,8-Didehydrocimigenol
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN3989 Erycibelline 107633-95-4 98%
Erycibelline
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
CP-868388 free base
T31083
CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslip...
Abietic Acid
T3090
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.
Oroxin A
TWS0787
Oroxin A (Baicalin-7-glucoside) is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhib...
Ailanthoidol
TN3366
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
Inolitazone dihydrochloride
T15580
Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Ino...
PPARα-MO-1
T10505
PPARα-MO-1 is a potent modulator of PPARα.
PPARδ agonist 9
T78806
PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic ...
CRX000227
T79129
CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].
PPARγ agonist 8
T79182
PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator respon...
DSO-5a
T79231
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. I...
Anti-NASH agent 1
T79454
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages ...
PPARγ-IN-2
T79678
"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes. Furthermore, PPARγ-IN-2 counter...
Foenumoside B
T79949
Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes lipo...
SP4f
T81120
SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose levels and lipid peroxidation whi...
SP4e
T81121
SP4e, a PPAR-γ activator, exhibits an EC50 of 739 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose and lipid peroxidation while enhancing glut...
Gentianine
TN1681
Gentianine is an effective Swertiamarin derivative, which has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, diuretic and other effects, and has t...
Fonadelpar
T15336
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
Kihadanin B
TN4390
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
7,8-Didehydrocimigenol
TN3219
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
Erycibelline
TN3989
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
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TargetMol