Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
TargetMol | Tags DNA Damage/DNA Repair
TargetMol | Tags Metabolism

PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Muraglitazar
T21587331741-94-7In house
Muraglitazar (BMS-298585) is a PPAR α γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM respectively.
  • $293
In Stock
Size
QTY
Fucosterol
T818417605-67-3
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C EBPα expression.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Ragaglitazar
T28501222834-30-2In house
Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes.
  • $639
In Stock
Size
QTY
GW6471
T8486880635-03-0
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
  • $32
In Stock
Size
QTY
TargetMol | Citations Cited
Rosiglitazone
T0334122320-73-4
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Bilobetin
T4S2128521-32-4
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Pioglitazone
T0214111025-46-8
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione indicated for the treatment of type 2 diabetes, and has been linked to rare instances of acute liver injury.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Farglitazar
T27303196808-45-4In house
Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer that inhibits stellate cell activation by activating receptor γ via oxidative enzymes proliferators and is used in the study of diabetes.
  • $293 TargetMol
In Stock
Size
QTY
Astaxanthin
T3138472-61-7
Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aquatic organisms. Astaxanthin has shown to mediate anti-oxidant and anti-inflammatory actions. It may be found in fish feed or some animal food as a color additive.
  • $30
In Stock
Size
QTY
Oleuropein
T691732619-42-4
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
  • $43
In Stock
Size
QTY
GW9662
T226022978-25-2
GW9662 (TIMTEC-BB SBB006523) is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
  • $47
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
GW7647
T15453265129-71-3
GW 7647 is an effective and highly selective PPARα agonist, the EC 50 values of human PPARα, PPARγ and PPARδ receptors are 6,1100 and 6200 nM, respectively. GW 7647 can reduce the production of nitric oxide in macrophages and has lipid-lowering and anti-inflammatory properties in the body.
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Troglitazone
T317097322-87-7
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
Tesaglitazar
T17044251565-85-2In house
Tesaglitazar is a potent and selective peroxide PPARα γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0.2 μM for rat PPARγ and human PPARγ. Tesaglitazar induced DNA synthesis and fibrosarcoma formation in rat subcutaneous mesenchymal cells.
  • $38
In Stock
Size
QTY
Aleglitazar
T14176475479-34-6In house
Aleglitazar (R1439) (R1439) is a potent dual PPARα γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.
  • $258
In Stock
Size
QTY
Saroglitazar
T12835495399-09-2
Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
  • $153
In Stock
Size
QTY
THR-0921
T69015606932-81-4
THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.
  • $293
In Stock
Size
QTY
Glabrone
TN169360008-02-8
Glabrone shows antiviral activity against influenza virus.
  • $117
In Stock
Size
QTY
Mavodelpar free acid hydrochloride
T12527L In house
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.
  • $329
In Stock
Size
QTY
Suksdorfin
T6914653023-17-9In house
Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by adipocytes, and can be used to study obesity.
  • $293 TargetMol
In Stock
Size
QTY
Linotroban
T25741120824-08-0In house
Linotroban(CL-871502) is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.
  • $373 TargetMol
In Stock
Size
QTY
Reglitazar
T28511170861-63-9In house
Reglitazar (JTT-501) is a dual PPARα and PPARγ agonist that is used to study diabetes.
  • $293
In Stock
Size
QTY
Sakuranetin
TN11262957-21-3
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
  • $40
In Stock
Size
QTY
Norathyriol
TN19903542-72-1
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
  • $152
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Icariin
T2855489-32-7
Icariin (Ieariline) belongs to the flavonol glycoside group of natural products, can inhibit PDE5 and PDE4 activity (IC50=432 73.50 μM), is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.
  • $33
In Stock
Size
QTY
TargetMol | Citations Cited
Arhalofenate
T1602224136-23-0
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
  • $133
In Stock
Size
QTY
Elafibranor
T4408923978-27-2
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Naringenin
T2838480-41-1
Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
  • $50
In Stock
Size
QTY
TargetMol | Citations Cited
SR1664
T233891338259-05-4In house
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.
  • $48
In Stock
Size
QTY
LY518674
T15821425671-29-0
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
  • $179
In Stock
Size
QTY
ARH-049020
T26656251454-45-2In house
ARH-049020 (ARH049020) is a PPAR agonist used in the study of type 2 diabetes.
  • $293 TargetMol
In Stock
Size
QTY
Tetramethylkaempferol
TN513716692-52-7
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Tetramethylkaempferol can concentration-dependently enh
  • $106
In Stock
Size
QTY
CDDO-Im
TQ0120443104-02-7
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232 344 nM for PPARα PPARγ).
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
GSK376501A
T154401010412-80-2
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
  • $325
In Stock
Size
QTY
GW1929
TQ0156196808-24-9
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
  • $30
In Stock
Size
QTY
(±)4-HDHA
T3660290906-40-4In house
(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is a PPARγ agonist with anti-inflammatory activity that directly inhibits endothelial cell proliferation and sprouting angiogenesis via PPARγ, which can be used in the study of diabetes.
  • $193
In Stock
Size
QTY
Glabridin
T340359870-68-7
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
Ciglitazone
T1971074772-77-3
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
  • $91
In Stock
Size
QTY
Bocidelpar
T395162095128-20-2
Bocidelpar is a modulator of PPARδ with an EC50 of 7.80 nM and improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy muscle cells.
  • $123
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Pirinixic Acid
T226950892-23-4
Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated receptors (PPAR).
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
T0070907
T6689313516-66-4
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Daidzein
T1238486-66-8
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
K-111
T27706221564-97-2In house
K-111 (BM-170744) is an orally available peroxisome proliferator-activated receptor (PPAR)-alpha agonist and insulin enhancer for the study of obesity-type diabetes mellitus and the metabolic syndrome.
  • $293 TargetMol
In Stock
Size
QTY
Licochalcone E
TN1055864232-34-8
Licochalcone E is a potential LXRβ agonist.
  • $98
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Agrimol B
T4S117355576-66-4
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
  • $116
In Stock
Size
QTY
Pemafibrate
TQ0107848259-27-8
Pemafibrate ((R)-K-13675) is a highly specific PPARα agonist (EC50: 1 nM).
    Inquiry
    TargetMol | Citations Cited
    Licarin B
    T4S154551020-87-2
    1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
    • $33
    In Stock
    Size
    QTY
    GSK0660
    T26741014691-61-2
    GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale