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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1525 Convallatoxin 508-75-8 98%
Convallatoxin is a natural product
T15567 Imiglitazar 250601-04-8 98%
Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
TN2228 Soyasaponin Aa 117230-33-8 98%
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the down...
T15336 Fonadelpar 515138-06-4 98%
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
T15440 GSK376501A 1010412-80-2 98%
GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
TN1681 Gentianine 439-89-4 98%
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
TN3655 Cimiside E 154822-57-8 98%
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
T15049 Daltroban 79094-20-5 98%
Daltroban is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intracellular calc...
TN2641 15-Methoxypinusolidic acid 769928-72-5 98%
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN3219 7,8-Didehydrocimigenol 150972-72-8 98%
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN3989 Erycibelline 107633-95-4 98%
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T10327 Ankaflavin 50980-32-0 98%
Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and induc...
TMA0127 Ficusin A 173429-83-9 98%
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ in...
T16739 RG-12525 120128-20-3 98%
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN5149 Tirotundin 56377-67-4 98%
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activati...
T10506 PPAR agonist 1 539813-69-9 98%
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
TN1703 Glycyrin 66056-18-6 98%
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
TN5091 Tagitinin A 59979-61-2 98%
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the g...
TN4094 Gallocatechin gallate 5127-64-0 98%
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TWS0787 Oroxin A 31567-75-6 98%
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against ...
Convallatoxin
TN1525
Convallatoxin is a natural product
Imiglitazar
T15567
Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
Soyasaponin Aa
TN2228
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the down...
Fonadelpar
T15336
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
GSK376501A
T15440
GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
Gentianine
TN1681
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
Cimiside E
TN3655
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
Daltroban
T15049
Daltroban is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intracellular calc...
15-Methoxypinusolidic acid
TN2641
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
7,8-Didehydrocimigenol
TN3219
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
Erycibelline
TN3989
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
Ankaflavin
T10327
Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and induc...
Ficusin A
TMA0127
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ in...
RG-12525
T16739
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
Tirotundin
TN5149
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activati...
PPAR agonist 1
T10506
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
Glycyrin
TN1703
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
Tagitinin A
TN5091
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the g...
Gallocatechin gallate
TN4094
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Oroxin A
TWS0787
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against ...
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