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Metabolism PPAR

PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Cat No. product name
T8780 INT-131 INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatmen...
T2985 Gypenoside XLIX Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition
T2269 Pirinixic Acid Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T1264 Ciprofibrate Ciprofibrate is a fibrate derivative with antilipidemic activity.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T6926 Palmidrol Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
T2932 Ginsenoside Rh1 Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T1298 Clofibrate Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T1807 JW55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3941 Choline Fenofibrate Choline Fenofibrate is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T0061 Clofibric acid Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T3170 Troglitazone Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T1238 Daidzein Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
T4449 LB100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
T4353 SR18292 SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
T4408 Elafibranor Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
T4628 MBX 8025 MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
T4S2128 Bilobetin Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
TWS0787 Oroxin A Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
T5532 BMS-687453 BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
T5764 Alliin Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...
T5806 Growth hormone releasing peptide Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and ...
T5891 D-ERYTHRO-SPHINGOSINE D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T7159 L-165041 L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
T7395 Lanifibranor
T7535 3-Guanidinopropionic Acid 3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels an...
T1149 Fenofibrate Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
T3138 Astaxanthin Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activit...
TQ0107 Pemafibrate Pemafibrate is a highly specific PPARα agonist (EC50: 1 nM).
T3254 PHYTOL Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as...
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T0214 Pioglitazone Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
T0214L Pioglitazone hydrochloride Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
T2396 Ramatroban Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
T3709 XMD8-87 XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
T3710 XMD16-5 XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
T1088 Repaglinide Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3917 Protopanaxatriol Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
T3954 Adelmidrol Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T1941 GSK3787 GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
T3056 Bavachinin Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.
T3362 Eupatilin Eupatilin, a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T2260 GW 9662 GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T1415 Gemfibrozil Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
T1603 Glipizide Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T6646 Rosiglitazone HCl Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T6689 T0070907 T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T6151 GW501516 GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T6524 GW0742 GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).
T0705 Triflusal Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T0841 Bezafibrate Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T7443 4'-Methoxychalcone 4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
TQ0120 CDDO-Im CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
TN5149 Tirotundin Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
TN3152 6-Acetonyldihydrochelerythrine 6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
T15581 Inolitazone Inolitazone a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibition).
T15748 LG100754 LG100754 is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functio...
T11754 Ketorolac D5 Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM...
T15821 LY518674 LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist ...
T15945 MA-0204 MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, ...
T16022 Arhalofenate Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
T10506 PPAR agonist 1 PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T10505 PPARα-MO-1 PPARα-MO-1 is a potent modulator of PPARα extracted from patent WO/2004/110982A1 (formula I).
T16739 RG-12525 RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pep...
T17044 Tesaglitazar Tesaglitazar causes interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Tesaglitazar is a dual peroxisome proliferato...
T8486 GW 6471 GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins...
TN2535 1-Hydroxy-2-oxopomolic acid 1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN3219 7,8-Didehydrocimigenol 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
T15575 Indeglitazar Indeglitazar is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
TN3655 Cimiside E Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
TN3989 Erycibelline Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
TMA0127 Ficusin A Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ i...
TN4094 Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
TN4374 Kaerophyllin Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting ...
TN4390 Kihadanin B Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN4583 Moringin Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
TN4670 Norlichexanthone Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardio...
TN4860 Pueroside B Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
TN5091 Tagitinin A Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the ...
TN5137 Tetramethylkaempferol Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated wit...
T15580 Inolitazone dihydrochloride Inolitazone dihydrochloride is a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibi...
T15567 Imiglitazar Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
TQ0156 GW1929 GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
TN2228 Soyasaponin Aa Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the dow...
TQ0272 Balaglitazone Balaglitazone is a selective partial agonist for PPARγ (EC50: 1.351 μM for human PPARγ).
T8184 Fucosterol Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα an...
T7821 DG172 (dihydrochloride) DG172 (dihydrochloride) is an  antagonist of  PPARβ/δ(IC50 : 27 nM).
T8374 LJ570 LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)
TN1018 Angeloylgomisin H Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
TN1055 Licochalcone E Licochalcone E is a potential LXRβ agonist.
TN1126 Sakuranetin Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
TN1189 13-Methylberberine 13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
TN1681 Gentianine Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
TN1693 Glabrone Glabrone shows antiviral activity against influenza virus.
TN1703 Glycyrin Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
TN1804 Isosilybin A Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
TN1836 Kudinoside D Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
TN2290 Uvaol Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
T15453 GW7647 GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively).
T12268 NTP42 NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T12296 Oleoylethanolamide Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.
T12527 PPARδ agonist PPARδ agonist is an agonist of PPARδ.
T12529 Pparδ agonist 2 Pparδ agonist 2 is an agonist of PPARδ.
T10044 13-Oxo-9E,11E-octadecadienoic acid 13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases...
T14176 Aleglitazar Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar...
T14356 AVE-8134 AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.
T10327 Ankaflavin Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and ind...
T16074 Mifobate Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
T14948 Chiglitazar Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
T15243 Ertiprotafib Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM...
T15336 Fonadelpar Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
T13289 VCE-​004.8 VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-ind...
T15440 GSK376501A GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
T2674 GSK0660 GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
INT-131
T8780CAS 315224-26-1
INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatmen...
Gypenoside XLIX
T2985CAS 94987-08-3
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition
Pirinixic Acid
T2269CAS 50892-23-4
Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates spe...
Dexibuprofen
T0448CAS 51146-56-6
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Abietic Acid
T3090CAS 514-10-3
Abietic Acid is the primary component of resin acid isolated from rosin.
Ciprofibrate
T1264CAS 52214-84-3
Ciprofibrate is a fibrate derivative with antilipidemic activity.
Magnolol
T3000CAS 528-43-8
Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
Palmidrol
T6926CAS 544-31-0
Palmitoylethanolamide(PEA) , an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
Ginsenoside Rh1
T2932CAS 63223-86-9
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
Clofibrate
T1298CAS 637-07-0
Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
JW55
T1807CAS 664993-53-7
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
WIKI4
T3062CAS 838818-26-1
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
Choline Fenofibrate
T3941CAS 856676-23-8
Choline Fenofibrate is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
Clofibric acid
T0061CAS 882-09-7
Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
Mesalamine
T0646CAS 89-57-6
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
Troglitazone
T3170CAS 97322-87-7
Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
Daidzein
T1238CAS 486-66-8
Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic prope...
LB100
T4449CAS 1632032-53-1
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
SR18292
T4353CAS 2095432-55-4
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose ...
Elafibranor
T4408CAS 923978-27-2
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 v...
MBX 8025
T4628CAS 851528-79-5
MBX-8025 has been used in trials studying the treatment of Hyperlipidemia.
Bilobetin
T4S2128CAS 521-32-4
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
Oroxin A
TWS0787CAS 31567-75-6
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
BMS-687453
T5532CAS 1000998-59-3
BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma i...
Alliin
T5764CAS 556-27-4
Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which ...
Growth hormone releasing peptide
T5806CAS 87616-84-0
Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and ...
D-ERYTHRO-SPHINGOSINE
T5891CAS 123-78-4
D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
L-165041
T7159CAS 79558-09-1
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
Lanifibranor
T7395CAS 927961-18-0
3-Guanidinopropionic Acid
T7535CAS 353-09-3
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels an...
Fenofibrate
T1149CAS 49562-28-9
Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic...
Astaxanthin
T3138CAS 472-61-7
Astaxanthin is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activit...
Pemafibrate
TQ0107CAS 848259-27-8
Pemafibrate is a highly specific PPARα agonist (EC50: 1 nM).
PHYTOL
T3254CAS 150-86-7
Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as...
Nateglinide
T1674CAS 105816-04-4
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
FH535
T2413CAS 108409-83-2
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
Pioglitazone
T0214CAS 111025-46-8
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare ...
Pioglitazone hydrochloride
T0214LCAS 112529-15-4
Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Seratrodast
T0212CAS 112665-43-7
Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist d...
Ramatroban
T2396CAS 116649-85-5
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
Rosiglitazone
T0334CAS 122320-73-4
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rar...
XMD8-87
T3709CAS 1234480-46-6
XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mut...
XMD16-5
T3710CAS 1345098-78-3
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted ...
Repaglinide
T1088CAS 135062-02-1
Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
G007-LK
T6842CAS 1380672-07-0
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
NVP-TNKS656
T3261CAS 1419949-20-4
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
Protopanaxatriol
T3917CAS 1453-93-6
Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
Rosiglitazone maleate
T1622CAS 155141-29-0
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activit...
Fenofibric acid
T1402CAS 42017-89-0
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
AZ6102
T6768CAS 1645286-75-4
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
Adelmidrol
T3954CAS 1675-66-7
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
GSK3787
T1941CAS 188591-46-0
GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
Bavachinin
T3056CAS 19879-30-2
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.
Eupatilin
T3362CAS 22368-21-4
Eupatilin, a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
GW 9662
T2260CAS 22978-25-2
GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
Gemfibrozil
T1415CAS 25812-30-0
Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an in...
Glipizide
T1603CAS 29094-61-9
Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Rosiglitazone HCl
T6646CAS 302543-62-0
Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T0070907
T6689CAS 313516-66-4
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
GW501516
T6151CAS 317318-70-0
GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
GW0742
T6524CAS 317318-84-6
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).
Triflusal
T0705CAS 322-79-2
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
Bezafibrate
T0841CAS 41859-67-0
Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
4'-Methoxychalcone
T7443CAS 959-23-9
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
CDDO-Im
TQ0120CAS 443104-02-7
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
Tirotundin
TN5149CAS 56377-67-4
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the acti...
6-Acetonyldihydrochelerythrine
TN3152CAS 22864-92-2
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
Inolitazone
T15581CAS 223132-37-4
Inolitazone a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibition).
LG100754
T15748CAS 180713-37-5
LG100754 is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functio...
Ketorolac D5
T11754CAS 1215767-66-0
Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM...
LY518674
T15821CAS 425671-29-0
LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist ...
MA-0204
T15945CAS 2095128-17-7
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, ...
Arhalofenate
T16022CAS 24136-23-0
Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
PPAR agonist 1
T10506CAS 539813-69-9
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
PPARα-MO-1
T10505CAS 810677-36-2
PPARα-MO-1 is a potent modulator of PPARα extracted from patent WO/2004/110982A1 (formula I).
RG-12525
T16739CAS 120128-20-3
RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pep...
Tesaglitazar
T17044CAS 251565-85-2
Tesaglitazar causes interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Tesaglitazar is a dual peroxisome proliferato...
GW 6471
T8486CAS 880635-03-0
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins...
1-Hydroxy-2-oxopomolic acid
TN2535CAS 217466-37-0
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
7,8-Didehydrocimigenol
TN3219CAS 150972-72-8
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
Indeglitazar
T15575CAS 835619-41-5
Indeglitazar is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
Ailanthoidol
TN3366CAS 156398-61-7
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
Cimiside E
TN3655CAS 154822-57-8
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1...
Erycibelline
TN3989CAS 107633-95-4
Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
Ficusin A
TMA0127CAS 173429-83-9
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ i...
Gallocatechin gallate
TN4094CAS 5127-64-0
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
Kaerophyllin
TN4374CAS 75590-33-9
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting ...
Kihadanin B
TN4390CAS 73793-68-7
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
Moringin
TN4583CAS 73255-40-0
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
Norlichexanthone
TN4670CAS 20716-98-7
Norlichexanthone has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardio...
Pueroside B
TN4860CAS 100692-54-4
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-...
Tagitinin A
TN5091CAS 59979-61-2
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the ...
Tetramethylkaempferol
TN5137CAS 16692-52-7
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated wit...
Inolitazone dihydrochloride
T15580CAS 223132-38-5
Inolitazone dihydrochloride is a novel high-affinity agonist of PPARγ. It is dependent upon PPARγ for its biological activity (IC50: 0.8 nM for growth inhibi...
Imiglitazar
T15567CAS 250601-04-8
Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist (EC50: 67 and 31 nM).
GW1929
TQ0156CAS 196808-24-9
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
Soyasaponin Aa
TN2228CAS 117230-33-8
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the dow...
Balaglitazone
TQ0272CAS 199113-98-9
Balaglitazone is a selective partial agonist for PPARγ (EC50: 1.351 μM for human PPARγ).
Fucosterol
T8184CAS 17605-67-3
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα an...
DG172 (dihydrochloride)
T7821CAS 1361504-77-9
DG172 (dihydrochloride) is an  antagonist of  PPARβ/δ(IC50 : 27 nM).
LJ570
T8374CAS 2252488-69-8
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)
Angeloylgomisin H
TN1018CAS 66056-22-2
Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
Licochalcone E
TN1055CAS 864232-34-8
Licochalcone E is a potential LXRβ agonist.
Sakuranetin
TN1126CAS 2957-21-3
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
13-Methylberberine
TN1189CAS 54260-72-9
13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
Gentianine
TN1681CAS 439-89-4
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
Glabrone
TN1693CAS 60008-02-8
Glabrone shows antiviral activity against influenza virus.
Glycyrin
TN1703CAS 66056-18-6
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
Isosilybin A
TN1804CAS 142796-21-2
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
Kudinoside D
TN1836CAS 173792-61-5
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
Uvaol
TN2290CAS 545-46-0
Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
GW7647
T15453CAS 265129-71-3
GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively).
NTP42
T12268CAS 2055599-51-2
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
Oleoylethanolamide
T12296CAS 111-58-0
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.
PPARδ agonist
T12527CAS 942594-93-6
PPARδ agonist is an agonist of PPARδ.
Pparδ agonist 2
T12529CAS 870884-12-1
Pparδ agonist 2 is an agonist of PPARδ.
13-Oxo-9E,11E-octadecadienoic acid
T10044CAS 29623-29-8
13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases...
Aleglitazar
T14176CAS 475479-34-6
Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar...
AVE-8134
T14356CAS 304025-09-0
AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.
Ankaflavin
T10327CAS 50980-32-0
Ankaflavin is isolated from Monascus-Fermented red rice and is a PPARγ agonist with anti-inflammatory activity. It shows the selective cytotoxic effect and ind...
Mifobate
T16074CAS 76541-72-5
Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
Chiglitazar
T14948CAS 743438-45-1
Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
Ertiprotafib
T15243CAS 251303-04-5
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM...
Fonadelpar
T15336CAS 515138-06-4
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.
VCE-​004.8
T13289CAS 1818428-24-8
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-ind...
GSK376501A
T15440CAS 1010412-80-2
GSK376501A is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). It is used for the treatment of type 2 diabetes mellitus.
GSK0660
T2674CAS 1014691-61-2
GSK0660 is an antagonist and inverse agonist of PPARβ/δ.