at3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62491	STAT3-IN-13		STAT
	STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which in...		STAT
T13009	STAT3-IN-1		Apoptosis , STAT
	STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.		Apoptosis , STAT
T5198	Bobcat339	Bobcat339 hydrochloride	DNA Methyltransferase
	Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.		DNA Methyltransferase
T28865	STAT3-IN-B9	STAT3 IN B9,B9	STAT
	STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.		STAT
T71550	STAT3-IN-8		STAT
	"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."		STAT
T62317	α7 nAchR-JAK2-STAT3 agonist 1
	α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
T79662	STAT3-IN-20		STAT
	STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear translocation, and subsequent gene transcription. The compound...		STAT
T63426	MGAT3/4-IN-1
	mGAT3/4-IN-1 is a potent inhibitor of mGAT3/mGAT4, and their pIC50 values were 5.31 and 5.24, respectively. mGAT3/4-IN-1 significantly inhibited tactile abnormal pain in diabetic neuropathic mice.
T13010	STAT3-IN-3		STAT
	STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.		STAT
T72754	JAK2/STAT3-IN-1
	JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T71351	STAT3-IN-A69
	STAT3-IN-A69 is an inhibitor targeting the DNA-binding domain of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo.
T62803	STAT3-IN-12
	STAT3-IN-12 is a potent inhibitor of STAT3 signalling and inhibits IL-6-induced activation of the JAK/STAT3 signalling pathway. STAT3-IN-12 inhibits the growth and migration of cancer cells, blocks the cell cycle and ind...
T64629	Phospho-Stat3 (Tyr705) Antibody #9131R
	Phospho-Stat3 (Tyr705) Antibody #9131R is a useful organic compound for research related to life sciences and the catalog number is T64629.
T61012	Bobcat339 hydrochloride
	Bobcat339 hydrochloride can be used in the field of epigenetics and as a starting point for new therapeutics targeting DNA methylation and gene transcription. Bobcat339 hydrochloride is a potent and selective cytosine-ba...
T73114	STAT3-IN-7
	STAT3-IN-7, an orally active aryl sulfonamido azetidine compound, serves as a STAT3 inhibitor with anticancer activities.
T61030	STAT3-IN-11		Apoptosis , STAT
	STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound fo...		Apoptosis , STAT
TP2222L	APTSTAT3-9R acetate		STAT
	APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphoryl...		STAT
T64573	Stat3 (124H6) Mouse mAb #9139M
	Stat3 (124H6) Mouse mAb #9139M is a useful organic compound for research related to life sciences and the catalog number is T64573.
T78983	STAT3 degrader-2		STAT
	STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].		STAT
T79609	STAT3-IN-18		JAK
	STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptos...		JAK
T60765	STAT3-IN-10
	STAT3-IN-10 (A11) is an inhibitor of STAT3 that directly binds to STAT3 SH2 domain, inhibits tumor cell growth and induces apoptosis in cancer cells (IC 50 = 5.18 μM) [1].
T75099	PROTAC STAT3 degrader-2
	PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC 50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research [1] .
TP2222	APTSTAT3-9R		Others
	APTSTAT3-9R-9R is a STAT3 inhibitor (Ki: 231 nmol/L). STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target fo...		Others
T74545	STAT3 degrader-1
	STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].
T63408	MGAT3/4-IN-2
	mGAT3/4-IN-2 are potent inhibitors of mGAT3/mGAT4 with their pIC50 values of 5.44 and 5.25, respectively.
T73035	STAT3-IN-15
	STAT3-IN-15, a potent and orally active inhibitor targeting STAT3, effectively combats idiopathic pulmonary fibrosis (IPF) by hindering STAT3 phosphorylation. Additionally, it impedes TGF-β1-induced migration and deforma...
T61779	STAT3-IN-9
	STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at...

Compounds

STAT3-IN-13

T62491

Target: Apoptosis, STAT

Bobcat339

T5198

Synonym: Bobcat339 hydrochloride

Target: DNA Methyltransferase

STAT3-IN-B9

T28865

Synonym: STAT3 IN B9,B9

α7 nAchR-JAK2-STAT3 agonist 1

Phospho-Stat3 (Tyr705) Antibody #9131R

T64629

Synonym:

Target:

Bobcat339 hydrochloride

Target: Apoptosis, STAT

Stat3 (124H6) Mouse mAb #9139M

PROTAC STAT3 degrader-2

Cat No.	Product Name	Synonyms	Targets
T73070	STAT3-IN-14
	STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00916	Antithrombin III Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Antithrombin III Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.5 kDa and the accession number is A0A024R944.
TMPH-02539	MGAT3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannos...
TMPY-06624	STAT3 Protein, Human, Recombinant (His)	Human	E. coli
	STAT3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 65.31 kDa and the accession number is P40763-1.
TMPY-00569	B3GAT3 Protein, Human, Recombinant (His)	Human	E. coli
	B3GAT3, encoding beta-1,3-glucuronyltransferase 3, has an important role in proteoglycan biosynthesis. Homozygous B3GAT3 mutations have been associated with short stature, skeletal deformities, and congenital heart defec...