synthetase

Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).

H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM, exhibiting anti-cancer activity.

NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

Chlorobenzuron, a chitin synthetase inhibitor, functions as an insecticide by inhibiting larval development and pupation.

Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).

Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.

Aminoacyl tRNA synthetase-IN-1 is an inhibitor of bacterial aminoacyl tRNA synthetase (aaRS).

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.

CTP Synthetase-IN-1 Ammonium salt is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antimicrobial, anti-inflammatory and antitumor activity for the study of SARS-CoV-2 viral infections.

Trypanothione synthetase-IN-5 (compound 9) is an inhibitor of trypanothione reductase (TR), showing an IC50 of 20.5 μM against Leishmania infantum TR. It also exhibits inhibitory activity against human glutathione reductase (hGR), with an IC50 of 62.4 μM.

Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysyl-tRNA synthetase (PfLysRS) in Plasmodium falciparum with an IC50 value of 59.2 nM. It works by occupying the ATP and L-lysine binding sites of PfLysRS, thereby inhibiting its activity. This compound is a potential candidate for antimalarial drug development.

Isoleucyl tRNA synthetase-IN-1 is a selective and potent inhibitor (Ki: 88 nM) that targets isoleucyl tRNA synthetase (IleRS).

Isoleucyl tRNA synthetase-IN-2 is a selective and potent inhibitor (Ki: 114 nM) that targets isoleucyl tRNA synthetase (IleRS).

Trypanothione synthetase-IN-4, a L. infantumTryS inhibitor, exhibits a strong anti-leishmanicidal effect (EC50: 0.6 μM, SI) dependent on the concentration of the polyamine substrate and can be used to study leishmaniasis.

Aminoacyl tRNA Synthetase-IN-2 (Compound 14) serves as an inhibitor of aminoacyl-tRNA synthetase (aaRS), presenting potential for the formulation of a novel class of antibiotics [1].

Trypanothione Synthetase-IN-1 (Compound 1) serves as a competitive inhibitor of Leishmania infantum trypanothione synthetase (TryS), demonstrating an IC50 value of 14.8 μM in the presence of the polyamine S, triamine spermidine [1].

Trypanothione Synthetase-IN-2 (Compound 3) functions as a competitive inhibitor of Leishmania infantum trypanothione synthetase (TryS), demonstrating an inhibition constant (IC50) of 5.4 μM in the presence of the polyamine S, triamine spermidine [1].

Trypanothione Synthetase-IN-3, a mixed noncompetitive inhibitor of Trypanothione Synthetase (TryS) with an inhibition constant (Ki) of 0.8 μM, is useful in researching parasites like L. infantum [1].

Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, catalyzes the activation of fatty acids via coenzyme A through a two-step thioesterification process, forming acyl coenzyme A. It is crucial in anabolic and catabolic lipid metabolism pathways and contributes to the tricarboxylic acid (TCA) cycle during aerobic respiration [1].

Acetyl-CoA synthetase (ACS) is a biochemical reagent utilized as a biomaterial or organic compound in life science research.

2'-5' Oligoadenylate Synthetase 1, Human is an interferon-induced enzyme that is activated in the presence of double-stranded RNA, promoting the oligomerization of ATP into 2′,5′-linked oligoadenylates (2-5A). It plays a crucial role in the inflammatory immune response.

Glutathione Synthetase, Human catalyzes the synthesis of glutathione from γ-glutamylcysteine and glycine in an ATP-dependent manner.

Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) is part of the ligase enzyme family that facilitates the breakdown of complex fatty acids. This enzyme catalyzes the formation of acyl-coenzyme A through a two-step process involving an adenylated intermediate. It plays a role in the initial phase of fatty acid β-oxidation and can integrate into phospholipids. Additionally, Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) is involved in both regulating and enhancing the transport of long-chain fatty acids within mammalian cells.