sth

STh, also known as Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide containing three disulfide bridges. It serves as an antigen of significance in the quest for a comprehensive enterotoxigenic Escherichia coli (ETEC) vaccine.

Antiasthmatic Compound 1 is an antiasthmatic agent.

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, as well as for protein and cell labeling, detection, and separation.

Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.

Asthma relating compound 1 is a potential anti-asthma compound.

Closthioamide is a potent inhibitor of bacterial DNA gyrase and is highly effective against MRSA, Ec, VRE, and Mv [MICs: 0.58 μM, 9.00 μM, 0.58 μM, and 72.03 μM, respectively].

Pestheic acid is a useful organic compound for research related to life sciences. The catalog number is T125639 and the CAS number is 165905-02-2.

Osthenone is a useful organic compound for research related to life sciences and the catalog number is T126372.

(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin is a polyethylene glycol (PEG)-based PROTAC linker used for the synthesis of PROTACs.

DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker utilized in the synthesis of PROTACs [1].

N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound used in the synthesis of PROTACs, which are bifunctional molecules aimed at targeted protein degradation[1].

Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir.

Transthyretin-IN-3 (compound 6) is a synthetically designed benzofuran analogue. It selectively binds with transthyretin in plasma, inhibiting amyloid aggregation with an IC50 of 5.0±0.2 μM. By incorporating a chlorine substituent at a specific position, Transthyretin-IN-3 effectively targets the thyroxine binding site of TTR, preventing the dissociation of TTR tetramers into unstable monomers.

Hydrazide-PEG4-Desthiobiotin is a PROTAC linker of the PEG class, utilized for the synthesis of PROTAC molecules.

Transthyretin-IN-4 (Compound B26) is a bivalent inhibitor of transthyretin (TTR) amyloidosis, with a bIC50 of 0.09 µM and a pIC50 of 1.4 µM. It is applicable for research in heart failure with preserved ejection fraction (HFpEF) and life-threatening arrhythmias.

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Desthiobiotin-PEG4-propargyl is a PEG-coupled PROteolysis TArgeting Chimeric (PROTAC) linker used in PROTAC synthesis.

Amine-PEG3-Desthiobiotin is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system [within cells].

Amine-PEG4-Desthiobiotin is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer's disease [1].

Bisthianostat, also known as CF367 or CF367;-C, is a novel Orally Efficacious Pan-HDAC Inhibitor. Bisthianostat selectively binds to and inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes. This prevents cell division, induces cell cycle arrest and apoptosis. This may inhibit the proliferation of susceptible tumor cells. HDACs, upregulated in many tumor cell types, are a family of enzymes that deacetylate histone proteins.

Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a better therapeutic index than arsenic trioxide, as estimated by the ratio LD50/IC50. Arsthinol induced growth inhibition of NB4 cells at lower concentration (IC50 (concentration inhibiting growth by 50%) = 0.78 +/- 0.08 micromol/l after 24 h) than As(2)O(3) (IC50 = 1.60 +/- 0.23 micromol/l after 24 h) or melarsoprol (IC50 = 1.44 +/- 0.08 micromol/l after 24 h). Arsthinol-cyclodextrin complex demonstrated to have was more effective than arsenic trioxide (As2O3) and melarsoprol on the U87 MG cell line. Importantly, in the in vivo study, significant antitumor activity against heterotopic xenografts was observed after i.p. administration.

Desthiobiotin-Iodoacetamide is a functionalised reagent formed by linking desthiobiotin and iodoacetamide (IAM). It serves as a probe for investigating cysteine reactivity and may also function as an ADC Linker.