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Search Results for " immunosuppressive "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2548	Diflorasone		Glucocorticoid Receptor
	Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti...		Glucocorticoid Receptor
T9744	MP07-66		Phosphatase
	MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.		Phosphatase
T7776	ADH-503	GB1275	Complement System
	ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.		Complement System
T12399	Peldesine	BCX 34	Nucleoside Antimetabolite/Analog , HIV Protease
	Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in resear...		Nucleoside Antimetabolite/Analog , HIV Protease
T22697	CS 2100	1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid	S1P Receptor
	CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.		S1P Receptor
T13379	(Z)-Leukadherin-1	ADH-503 free base	Complement System
	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.		Complement System
T9603	MNITMT
	MNITMT is a potent immunosuppressive agent without bone marrow toxicity [1].
T7527	Frentizole		Beta Amyloid
	Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction		Beta Amyloid
T1237	Azathioprine	BW 57-322	Apoptosis , GPR , Rho
	Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.		Apoptosis , GPR , Rho
T7202	ITE		AhR , Aryl Hydrocarbon Receptor
	ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.		AhR , Aryl Hydrocarbon Receptor
T26046	Razoxane		Topoisomerase
	Razoxane is used as an antimitotic agent with immunosuppressive properties.		Topoisomerase
T16395	ONO4057	ONO-LB457	Leukotriene Receptor
	ONO4057 is a potent and orally active Leukotriene B4 receptor antagonist with an IC50 value of 0.7±0.3 μM. Immunosuppressive effect of ONO4057 on rat allografts.		Leukotriene Receptor
T0707	Cyclophosphamide hydrate	Cyclophosphamide monohydrate	DNA Alkylator/Crosslinker , DNA , MRP
	Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.		DNA Alkylator/Crosslinker , DNA , MRP
T20511	6-Thioguanosine	6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422	Others
	6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double ...		Others
T39615L	P8RI acetate		Integrin
	P8RI acetate is a biomimetic peptide of CD31 and an agonist of CDP8RI acetate shows an immunosuppressive effect through the restoration of the CD31 inhibitory pathway.		Integrin
T1550	Thiamphenicol	Dextrosulphenidol,Thiophenicol	Antibacterial , Antibiotic
	Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.		Antibacterial , Antibiotic
T24793	SIRT6-IN-5	SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5	Sirtuin
	SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ...		Sirtuin
T1163	Betamethasone valerate	Betnovate,Betaderm,Betamethasone 17-valerate,Luxiq	Glucocorticoid Receptor
	Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.		Glucocorticoid Receptor
T73698	Basiliximab	CHI 621	Interleukin
	Basiliximab (CHI 621) is a chimeric mouse/human IgG1 monoclonal recombinant antibody against the interleukin-2 receptor. Basiliximab has good immunosuppressive activity and can be used in the study of kidney transplantat...		Interleukin
T1485	Methotrexate	NCI-C04671,WR19039,Amethopterin,CL14377	Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T6120	Pralatrexate	Folotyn,10-Propargyl-10-deazaaminopterin	Apoptosis , DHFR , Antifolate , TAM Receptor
	Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...		Apoptosis , DHFR , Antifolate , TAM Receptor
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T20168	Aurothiomalate sodium	Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others , PKC
	Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ...		Others , PKC
T76699	Sabatolimab	MBG453,NVP-MBG453	Others
	Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selec...		Others
T1559	Betamethasone dipropionate	Diprolene AF,SCH 11460,Betamethasone 17,21-dipropionate,Diprolene,Diprosone	Glucocorticoid Receptor
	Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate (SCH 11460) binds to sp...		Glucocorticoid Receptor
T11134	DZ2002		Others
	DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibr...		Others
T41303	Isoflupredone	Delta-Fluorocortisone,Isoflupredona,Isoflupredonum,9-Fluoroprednisolone	Others
	Isoflupredone (Isoflupredonum) is a synthetic corticosteroid that acts in vivo by binding to glucocorticoid and corticosteroid receptors in animals (such as horses) to inhibit inflammatory cells and inhibit the expressio...		Others
T34952	Trinactin	Akd1D,Akd 1D,Akd-1D
	Trinactin is a nonactin homolog that has Immunosuppressive effects.
T25620	Lankacidinol	Antibiotic T 2636F,T2636 F,T-2636 F,T 2636 F
	Lankacidinol is an antibiotic that has antitumor and immunosuppressive activities.
T34361	Ro 4-6824	AI3-50843
	Ro 4-6824 is a biochemical with immunosuppressive action.
T21192	Diflorasone Diacetate	Apexicon E,Psorcon,Maxiflor,Florone E
	Diflorasone Diacetate, a topical glucocorticoid, has immunosuppressive and anti-inflammatory properties.
T16926	SR-31747		Others
	SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.		Others
T11941	Manitimus	FK778	Others
	Manitimus is a potent immunosuppressive drug, and is an inhibitor of dehydroorotate dehydrogenase,.		Others
T24815	Sotrastaurin acetate
	Sotrastaurin acetate is a pan-protein kinase C inhibitor. It also has potential immunosuppressive and antineoplastic activities.
T26457	A 85 4777	A85-4777,A 8547777
	A 85 4777, a homoperazine derivative, is an anti-inflammatory agent with nonclassical immunosuppressive properties.
T27661	JNJ-10329670
	JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
T14964	CI 972 anhydrous	CI 972 (anhydrous)	Others
	CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.		Others
T32113	Hydrocortamate Hydrochloride	UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort
	Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.
T38720	SR-31747 free base
	SR-31747 free base is an immunosuppressive and anti-inflammatory sigma ligand that efficiently inhibits cell proliferation through the inhibition of sterol isomerase activity.
T30136	Armepavine hydrochloride, (+/-)-	DL-Armepavine hydrochloride
	Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.
T11430	Glycosidase-IN-1		Others
	Glycosidase-IN-1 is a glycosidase inhibitor synthesized from D-mannose with hypoglycemic activity. It can be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors.		Others
T27368	FR 901235	FR901235,FR-901235
	FR-901235 is an immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 restores the mitogen-induced lymphocyte proliferation to a normal level, which has been suppressed by additio...
T33883	Paramethasone Acetate	NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP	Others
	Paramethasone Acetate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects that can be used in the treatment of systemic lupus erythematosus.		Others
T76228	ASP5286
	ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the research of HCV .
T39615	P8RI	D-P8RI
	P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive ...
T71048	Tacrolimus anhydrous 8-epimer
	Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-...
T7730L	Aminopterin sodium	NSC739,NSC 739 [as the base],NSC-739
	Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affini...
T25079	Aminopterin N-hydroxysuccinimide ester	Nhs-aminopterin,N-Hydroxysuccinimide aminopterin
	Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase...
T28266	Org-6906	Org6906,Org 6906,Org-6906 free
	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically...
T77155	Dalutrafusp alfa
	Dalutrafusp alfa (AGEN-1423; GS-1423) is a bifunctional antibody targeting CD73 and TGF-β, components of the immunosuppressive pathway [1].

Compounds

Diflorasone

T2548

Synonym:

Target: Glucocorticoid Receptor

Target: Complement System

Peldesine

T12399

Synonym: BCX 34

Target: Nucleoside Antimetabolite/Analog, HIV Protease

CS 2100

T22697

Synonym: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid

Target: S1P Receptor

(Z)-Leukadherin-1

T13379

Synonym: ADH-503 free base

Target: Complement System

Target: Apoptosis, GPR, Rho

ITE

T7202

Synonym:

Target: AhR, Aryl Hydrocarbon Receptor

Razoxane

T26046

Synonym:

Target: Topoisomerase

ONO4057

T16395

Synonym: ONO-LB457

Target: Leukotriene Receptor

Cyclophosphamide hydrate

T0707

Synonym: Cyclophosphamide monohydrate

Target: DNA Alkylator/Crosslinker, DNA, MRP

6-Thioguanosine

T20511

Synonym: 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422

Synonym: Dextrosulphenidol,Thiophenicol

Target: Antibacterial, Antibiotic

SIRT6-IN-5

T24793

Synonym: SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5

Target: Sirtuin

Betamethasone valerate

T1163

Synonym: Betnovate,Betaderm,Betamethasone 17-valerate,Luxiq

Target: Glucocorticoid Receptor

Synonym: NCI-C04671,WR19039,Amethopterin,CL14377

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Pralatrexate

T6120

Synonym: Folotyn,10-Propargyl-10-deazaaminopterin

Target: Apoptosis, DHFR, Antifolate, TAM Receptor

Dexamethasone

T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Aurothiomalate sodium

T20168

Synonym: Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

Sabatolimab

T76699

Synonym: MBG453,NVP-MBG453

Target: Others

Betamethasone dipropionate

T1559

Synonym: Diprolene AF,SCH 11460,Betamethasone 17,21-dipropionate,Diprolene,Diprosone

Target: Glucocorticoid Receptor

Synonym: Delta-Fluorocortisone,Isoflupredona,Isoflupredonum,9-Fluoroprednisolone

Target: Others

Trinactin

T34952

Synonym: Akd1D,Akd 1D,Akd-1D

Target:

Lankacidinol

T25620

Synonym: Antibiotic T 2636F,T2636 F,T-2636 F,T 2636 F

Diflorasone Diacetate

T21192

Synonym: Apexicon E,Psorcon,Maxiflor,Florone E

Synonym: A85-4777,A 8547777

Synonym: CI 972 (anhydrous)

Target: Others

Hydrocortamate Hydrochloride

T32113

Synonym: UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort

Armepavine hydrochloride, (+/-)-

T30136

Synonym: DL-Armepavine hydrochloride

Synonym: FR901235,FR-901235

Target:

Paramethasone Acetate

T33883

Synonym: NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP

Tacrolimus anhydrous 8-epimer

Synonym: NSC739,NSC 739 [as the base],NSC-739

Target:

Aminopterin N-hydroxysuccinimide ester

T25079

Synonym: Nhs-aminopterin,N-Hydroxysuccinimide aminopterin

Target:

Org-6906

T28266

Synonym: Org6906,Org 6906,Org-6906 free

Cat No.	Product Name	Synonyms	Targets
TQ0248	Alisol F		HBV
	Alisol F is a natural product from Alisma plantago-aquatica Linn and has many activities.		HBV
T7730	Aminopterin	APGA,4-Aminofolic acid	Antifolate
	Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase		Antifolate
T3603	Sodium lauryl sulfoacetate	Sodium houttuyfonate	NF-κB , MAPK
	Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.		NF-κB , MAPK
T1335	Mycophenolic acid	Mycophenolate,RS-61443	Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal
	Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
TQ0226	Jionoside B1		Others
	Jionoside B1 has immunosuppressive activity and shows the hepato-protective activity in the H2O2 induced liver injury experiments.		Others
TN1697	Glucosyringic acid		Immunology/Inflammation related
	Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro.		Immunology/Inflammation related
T5736	1,3-Dicaffeoylquinic acid	CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid	Reactive Oxygen Species , Akt , PI3K
	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.		Reactive Oxygen Species , Akt , PI3K
T1243	Hydrocortisone acetate	Cortisol 21-acetate,Hydrocortisone 21-acetate	Glucocorticoid Receptor , Annexin A , Endogenous Metabolite
	Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.		Glucocorticoid Receptor , Annexin A , Endogenous Metabolite
T6293	Mycophenolate Mofetil	TM-MMF,RS 61443	Apoptosis , Dehydrogenase , Drug Metabolite
	Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).		Apoptosis , Dehydrogenase , Drug Metabolite
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T20879	Tacrolimus monohydrate	FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506	Phosphatase , Others , Antibacterial , Antibiotic , Autophagy
	Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi...
TN1110	Shanziside	Shanzhiside	IL Receptor
	Shanziside (Shanzhiside) has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood...		IL Receptor
TN1507	Clematichinenoside AR		TNF , Autophagy
	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.		TNF , Autophagy
T2179	Triptolide	PG490,NSC 163062	Apoptosis , Mdm2 , HSP , NF-κB
	Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and ...		Apoptosis , Mdm2 , HSP , NF-κB
T13808	P-Coumaric Acid Ethyl Ester	Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate	Others , Drug Metabolite
	p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a potent immunosuppressive agent in treating autoimmune inflammato...		Others , Drug Metabolite
T36914	2-Hydroxyanthraquinone		Others
	2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...		Others
T5S1285	(+)-(3R,8S)-Falcarindiol	Falcarindiol	Others
	1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...		Others
T1188	Mizoribine	Bredinin,NSC 289637,HE 69	HCV Protease , SARS-CoV , Tyrosinase
	Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.		HCV Protease , SARS-CoV , Tyrosinase
T3418	Demethylzeylasteral	Demethylzeylasteral (T-96)	Apoptosis , UGT
	Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signal...		Apoptosis , UGT
T2996	Tetrandrine	NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A	Potassium Channel , Calcium Channel
	Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c...		Potassium Channel , Calcium Channel
T4S0867	Pogostone	DHELWANGIN	Apoptosis , Antibacterial , Autophagy
	1. Pogostone (DHELWANGIN) possesses potent anti-bacterial and anti-fungal activities, such as gram negative bacteria , gram positive bacteria, Escherichia coli. 2. Pogostone exhibits an immunosuppressive property by dire...		Apoptosis , Antibacterial , Autophagy
T6S2140	β-Anhydroicaritin	Anhydroicaritin,Beta-Anhydroicaritin	MMP , Others , TNF , Interleukin
	1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ...		MMP , Others , TNF , Interleukin
T5S2357	Acetylcorynoline	(+)-Corynoline Acetate,O-Acetylcorynoline	Antifungal
	1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3...		Antifungal
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
TMA2235	Triptobenzene H
	Triptobenzene H shows the significant immunosuppressive activity.
T75465	Mycestericin G
	Mycestericin G, a sphingosine-like fungal metabolite, demonstrates immunosuppressive activity [1].
TN5187	Triptoquinone B		IL Receptor
	Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells, it shows the significant immunosuppressive a...		IL Receptor
T75502	Brazilein
	Brazilein, an immunosuppressive compound extracted from Caesalpinia sappan L., effectively induces apoptosis in mouse spleen lymphocytes [1].
TN4841	Ptaquiloside
	Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
T8303	Cimicifugoside		Others
	Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor. It also shows immunosuppressive activity.		Others
T40643	Prodigiosin hydrochloride	Prodigiosine hydrochloride
	Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this ...
T72857	Maydispenoid A
	Maydispenoid A, a potent immunosuppressive compound, effectively inhibits murine splenocyte proliferation activated by both anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.
T35761	Carviolin
	Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes...
TN3403	Djalonensone	Alternariol monomethyl ether	Immunology/Inflammation related
	Djalonensone (Alternariol monomethyl ether), an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. It also p...		Immunology/Inflammation related
TN4778	Physalin H		gp120/CD4 , Antifection , Autophagy
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunos...		gp120/CD4 , Antifection , Autophagy
T19886	Cirsilineol	Fastigenin,SPM 927,Eupatrin	Apoptosis , COX , STAT
	Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathw...		Apoptosis , COX , STAT
TN4838	Pseurotin A		Antifection
	Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 val...		Antifection
T82565	Diayangambin	Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether
	Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) is a compound that inhibits cell proliferation, exhibiting an IC50 value of 1.5 μM in human monocytes. Additionally, it demonstrates immunosuppr...
T80777	Withaphysalin R
	Withaphysalin R (compound 5), a withanolide derived from the Solanaceae family, possesses an ergosterol-based steroid ester structure. This compound exhibits notable activities such as cytotoxic, immunosuppressive, antit...
T73925	α-D-Glucose-1-phosphate disodium hydrate
	α-D-Glucose-1-phosphate disodium hydrate serves multiple roles in medical and biochemical applications, including as a precursor in the synthesis of glucuronic acid, a cytostatic compound crucial for cardiopathic therapy...

Natural Products

Synonym: APGA,4-Aminofolic acid

Target: Antifolate

Sodium lauryl sulfoacetate

T3603

Synonym: Sodium houttuyfonate

Target: NF-κB, MAPK

Mycophenolic acid

T1335

Synonym: Mycophenolate,RS-61443

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite, Antibacterial, Antibiotic, UGT, Antifungal

Target: Immunology/Inflammation related

1,3-Dicaffeoylquinic acid

T5736

Synonym: CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid

Target: Reactive Oxygen Species, Akt, PI3K

Hydrocortisone acetate

T1243

Synonym: Cortisol 21-acetate,Hydrocortisone 21-acetate

Target: Glucocorticoid Receptor, Annexin A, Endogenous Metabolite

Mycophenolate Mofetil

T6293

Synonym: TM-MMF,RS 61443

Target: Apoptosis, Dehydrogenase, Drug Metabolite

Rapamycin

T1537

Synonym: Sirolimus,AY 22989,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Tacrolimus monohydrate

T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Clematichinenoside AR

TN1507

Synonym:

Target: TNF, Autophagy

Triptolide

T2179

Synonym: PG490,NSC 163062

Target: Apoptosis, Mdm2, HSP, NF-κB

p-Coumaric Acid Ethyl Ester

T13808

Synonym: Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate

Target: Others, Drug Metabolite

2-Hydroxyanthraquinone

T36914

Synonym:

Target: Others

(+)-(3R,8S)-Falcarindiol

T5S1285

Synonym: Falcarindiol

Target: Others

Mizoribine

T1188

Synonym: Bredinin,NSC 289637,HE 69

Target: HCV Protease, SARS-CoV, Tyrosinase

Demethylzeylasteral

T3418

Synonym: Demethylzeylasteral (T-96)

Target: Apoptosis, UGT

Tetrandrine

T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A

Target: Potassium Channel, Calcium Channel

Pogostone

T4S0867

Synonym: DHELWANGIN

Target: Apoptosis, Antibacterial, Autophagy

β-Anhydroicaritin

T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin

Target: MMP, Others, TNF, Interleukin

Acetylcorynoline

T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline

Target: Apoptosis, BCL, COX, UGT

Prodigiosin hydrochloride

T40643

Synonym: Prodigiosine hydrochloride

Synonym: Alternariol monomethyl ether

Target: Immunology/Inflammation related

Physalin H

TN4778

Synonym:

Target: gp120/CD4, Antifection, Autophagy

Cirsilineol

T19886

Synonym: Fastigenin,SPM 927,Eupatrin

Target: Apoptosis, COX, STAT

Synonym: Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether

α-D-Glucose-1-phosphate disodium hydrate

T73925

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-05338	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)	Human	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-05496	IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPK-01231	CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
TMPK-01230	CLEC2D Protein, Human, Recombinant (hFc & Avi)	Human	HEK293
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
TMPY-03859	DHRS9 Protein, Human, Recombinant (His)	Human	E. coli
	Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic bioma...
TMPJ-00021	LGALS1 Protein, Human, Recombinant (His)	Human	E. coli
	Galectin-1 is a member of growing family of evolutionary conserved animal lectins. Galectin-1 is widely expressed in many cells and tissues. Galectins consists of a Galectin domain and two Beta-galactoside binding domain...
TMPJ-01313	HIV-1 gp120 Protein (His)	HIV	Human Cells
	Envelope glycoprotein gp160 is single-pass type I membrane protein. The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. It is cleaved into the following 2 chai...
TMPK-00029	Glycophorin A Protein, Human, Recombinant (hFc)	Human	HEK293
	Granulomatosis with polyangiitis (GPA) presents a wide spectrum of manifestations from the common respiratory symptoms to infrequent neurological and cardiac complications. The challenge in diagnosis and management makes...
TMPK-00817	Glycophorin A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Granulomatosis with polyangiitis (GPA) presents a wide spectrum of manifestations from the common respiratory symptoms to infrequent neurological and cardiac complications. The challenge in diagnosis and management makes...
TMPK-00534	Glycophorin A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Granulomatosis with polyangiitis (GPA) presents a wide spectrum of manifestations from the common respiratory symptoms to infrequent neurological and cardiac complications. The challenge in diagnosis and management makes...
TMPK-00818	Glycophorin A Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Granulomatosis with polyangiitis (GPA) presents a wide spectrum of manifestations from the common respiratory symptoms to infrequent neurological and cardiac complications. The challenge in diagnosis and management makes...
TMPJ-01049	CYPA Protein, Human, Recombinant	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biolo...
TMPJ-01252	CLEC2D Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and im...
TMPY-03321	IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPJ-00189	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, an...
TMPY-05317	IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPJ-00624	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)	Marmoset	Human Cells
	T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in...
TMPJ-00174	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)	Mouse	Human Cells
	T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in...
TMPJ-00173	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)	Mouse	Human Cells
	T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in...
TMPY-03131	Galectin-1 Protein, Rat, Recombinant	Rat	E. coli
	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence simil...
TMPY-02102	Galectin-1 Protein, Mouse, Recombinant	Mouse	E. coli
	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence simil...
TMPY-06772	IDO Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1, and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degra...
TMPY-02928	IDO Protein, Human, Recombinant	Human	E. coli
	Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1, and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degra...
TMPY-06685	Galectin-1 Protein, Human, Recombinant (His)	Human	E. coli
	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence simil...
TMPY-00976	Galectin-1 Protein, Human, Recombinant	Human	E. coli
	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence simil...
TMPY-01821	IDO Protein, Human, Recombinant (His)	Human	E. coli
	Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1, and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degra...
TMPY-00326	Bikunin/AMBP Protein, Human, Recombinant (mFc)	Human	HEK293
	The AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kun...
TMPY-00363	Bikunin/AMBP Protein, Human, Recombinant (aa 206-348, His)	Human	Yeast
	The AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kun...
TMPY-03044	Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His)	Human	HEK293
	The AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kun...
TMPY-00161	Bikunin/AMBP Protein, Rat, Recombinant (His)	Rat	HEK293
	The AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kun...
TMPY-00808	FKBP12 Protein, Human, Recombinant (His)	Human	E. coli
	FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...
TMPY-01662	FKBP12 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As ...