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Prednisolone valerate acetate
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Catalog No. T20734Cas No. 72064-79-0
Alias Lidomex, Acepreval
Prednisolone valerate acetate (Lidomex) is a corticosteroid hormone and prodrug with anti-inflammatory and immunosuppressive effects, which is converted to the active form of Prednisolone upon administration and acts by targeting the glucocorticoid receptor.
Prednisolone valerate acetate
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Purity: 99.93%
Catalog No. T20734Alias Lidomex, AceprevalCas No. 72064-79-0
Prednisolone valerate acetate (Lidomex) is a corticosteroid hormone and prodrug with anti-inflammatory and immunosuppressive effects, which is converted to the active form of Prednisolone upon administration and acts by targeting the glucocorticoid receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $441 | - | In Stock | |
| 5 mg | $987 | - | In Stock | |
| 10 mg | $1,390 | - | In Stock | |
| 25 mg | $1,980 | - | In Stock | |
| 50 mg | $2,780 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
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Storage & Solubility Information
| Description | Prednisolone valerate acetate (Lidomex) is a corticosteroid hormone and prodrug with anti-inflammatory and immunosuppressive effects, which is converted to the active form of Prednisolone upon administration and acts by targeting the glucocorticoid receptor. |
| In vivo | Prednisolone valerate acetate (PVA) was administered to mice via s.c. injection at 0.03–1 mg/kg, with immune responses assessed at 24–48 h and 5–7 d for antibody production. PVA reduced spleen weight and splenic nucleated cell counts, suppressed hemolytic plaque-forming cell (PFC) formation, delayed-type hypersensitivity (DTH), and ConA-induced splenocyte proliferation. Notably, PVA inhibited LPS-induced splenocyte response and IgM antibody production at lower doses than hydrocortisone 17-butyrate (HB), indicating higher potency. Unlike HB and betamethasone 17-valerate (BV), PVA had no effect on PHA-P response. Its suppression of host defense against experimental E. coli infection was weaker than that of HB and BV. [1] |
| Synonyms | Lidomex, Acepreval |
| Molecular Weight | 486.6 |
| Formula | C28H38O7 |
| Cas No. | 72064-79-0 |
| Smiles | C(COC(C)=O)(=O)[C@]1(OC(CCCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H] |
| Relative Density. | 1.22 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (8.22 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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