MCF-7 cell

DMA is a fluorescent agent (λex=340 nm, λem=478 nm).

DMA trihydrochloride is a fluorescent agent (λex=340 nm, λem=478 nm).

PRMT5-targeted fluorescent ligand-1 (Compound 7) is a fluorescent ligand specific to PRMT5 that inhibits this target with an IC50 value of 29.39 nM. It demonstrates cellular imaging activity with strong fluorescence signals in MCF-7 cells, showing an IC50 of 29 nM. Additionally, it induces apoptosis (cell death). The compound's maximum excitation wavelength is 438 nm, and its maximum emission wavelength is 550 nm.

PROTACERα Degrader-11 is a selective ERα PROTAC degrader with intrinsic fluorescence (Ex: 366 nm, Em: 440 nm). It demonstrates strong anti-proliferative activity, selective ERα degradation, and fluorescence imaging capability in the MCF-7 breast cancer cell line. PROTACERα Degrader-11 induces G2/M phase arrest and apoptosis in MCF-7 cells. In athymic nude mice, it shows good safety with no acute toxic reactions at a dose of 500 mg/kg. PROTACERα Degrader-11 is suitable for breast cancer research.