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Results for "

κ opioid receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    150
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    40
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    1
    TargetMol | Inhibitory_Antibodies
  • Natural Products
    10
    TargetMol | Natural_Products
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    1
    TargetMol | Disease_Modeling_Products
Norbinaltorphimine dihydrochloride
nor-BNI dihydrochloride, Nor-BNI dihydrochloride, nor-Binaltorphimine dihydrochloride, Nor-Binaltorphimine dihydrochloride
T12241113158-34-2In house
Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.
  • Inquiry Price
10-14 weeks
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Cebranopadol
GRT6005
T5167863513-91-1
Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor, respectively.
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TargetMol | Inhibitor Hot
Trimebutine CTB salt
GIC1001
T274131456509-46-8In house
Trimebutine CTB salt (GIC-1001) is an opioid receptor agonist used in the study of pain.
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6-8 weeks
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SCH-486757
SCH486757, SCH 486757
T28728524019-25-8In house
SCH-486757 is an agonist of nociceptin-1 (NOP1) and orphanin FQ peptide receptors and is used in the study of cough.
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6-8 weeks
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CP 866087
T31081L519052-02-9In house
CP 866087 is an opioid receptor antagonist for the study of female sexual dysfunction.
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Mirtazapine
Org3770, 6-Azamianserin
T013785650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
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Loperamide hydrochloride
R-18553 (hydrochloride), Loperamide HCl, ADL 2-1294
T020934552-83-5
Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
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Progesterone
Pregn-4-ene-3,20-dione
T047857-83-0
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
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(-)-Menthol
Menthomenthol, Menthacamphor, L-Menthol, Levomenthol
T14072216-51-5
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
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Naltrexone hydrochloride
Trexan, Naltrexone HCl, Depade, Antaxone
T096316676-29-2
Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
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Salvinorin A
T2330683729-01-5
Salvinorin A is a non-nitrogenous κ-opioid selective agonist.
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Cerivastatin sodium
BAY W 6228 sodium
T10767143201-11-0
Cerivastatin sodium (BAY W 6228 sodium) is an orally active and highly potent HMG-CoA reductase inhibitor with lipid-lowering activity that can reduce low-density lipoprotein cholesterol levels. Cerivastatin sodium has anticancer effects and can be used to study primary hyperlipidemia.
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7-10 days
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[DPro10] Dynorphin A (1-11)acetate,porcine
[DPro10] Dynorphin A (1-11)acetate,porcine(94596-26-6 Free base)
T76341L
[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity.
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TargetMol | Inhibitor Sale
ML-335
T230021069498-96-9
ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor) DOR (δ-opioid receptor) heterodimer, with anti-injury sensory activity and pain inhibitory activity.
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6-8 weeks
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TargetMol | Inhibitor Sale
KOR agonist 3
T203358
KOR agonist 3 (Compound 5) is an agonist of the κ opioid receptor (κOR) with an EC50 of 0.88 nM. It also exhibits some activation of μOR, with an EC50 of 720 nM. However, KOR agonist 3 does not activate δOR at concentrations below 1 μM. Its ability to recruit β-Arrestin-2 is lower than that of U50488.
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LPK-26 hydrochloride
T204728492451-07-7
LPK-26 hydrochloride is a selective κ-opioid receptor agonist with a Ki value of 0.68 nM. LPK-26 demonstrates effective analgesic properties while exhibiting a lower potential for physical dependence, making it suitable for related research.
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10-14 weeks
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Opioid receptor agonist 1
T205161
Opioid receptor agonist1 (Compound 2638-28) is an orally active opioid receptor agonist that shows strong affinity for MOR, DOR, and KOR, with Ki values of 5, 24, and 212 nM, respectively. It exhibits analgesic activity in both the mouse warm water tail-flick model and the acetic acid writhing model.
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KOR agonist 4
T205240
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.
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Urotensin-II receptor antagonist-1
T2053471034708-07-0
Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).
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10-14 weeks
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Icalcaprant
T798482227384-17-8
Icalcaprant is a kappa-opioid receptor antagonist (KOR-A) that effectively blocks the kappa opioid receptors in the brain, which are implicated in various neurological and psychiatric conditions [1].
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8-10 weeks
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Leumorphin, human
T8193888846-98-4
Leumorphin, human, is a potent agonist of the kappa opioid receptor (κ opioid receptor) and inhibits the contraction of the guinea pig ileum's myenteric plexus-longitudinal muscle preparation [1].
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GSK1521498 free base
T11478L1007573-18-3
GSK1521498 free base is a potent and selective μ-opioid receptor antagonist with potential applications in treating disorders of compulsive consumption of food, alcohol, and drugs.
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6-8 weeks
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DOR agonist 2
T2003821212540-02-7
Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1 2 pathway. This compound is useful for research into neurodegenerative diseases.
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4-6 weeks
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R-6890
T2030283222-88-6
R-6890 is an opioid compound with analgesic properties.
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