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ICI 204,448

Name: ICI 204,448
Brand: TargetMol
SKU: T22850
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22850Cas No. 121264-04-8

Alias ICI-204448, ICI204448, ICI 204448

ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.

ICI 204,448

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Catalog No. T22850Alias ICI-204448, ICI204448, ICI 204448Cas No. 121264-04-8

ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$125	In Stock	In Stock
25 mg	$208	In Stock	In Stock
50 mg	$317	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

ICI 204,448 AI Summary

ICI 204,448 exhibits a diverse range of bioactivities, indicating its potential in various biological contexts. Specifically, it acts as a general anesthetic with a potency of 50118.7 nM and demonstrates differential inhibition of Plasmodium falciparum proliferation with potencies ranging from 12589.3 nM to 15848.9 nM. It is a potent inhibitor of Tau fibril formation at 177.8 nM and Human Peripheral Myelin Protein 22 expression/activity at 95283.4 nM. It inhibits histone lysine methyltransferase G9a at 10000.0 nM and 17782.8 nM, functions as an antagonist of the Neuropeptide S Receptor with a potency of 31622.8 nM, and inhibits AmpC Beta-Lactamase at 5011.9 nM. Additionally, it interacts with MPP8 Chromodomain (177.8 nM), inhibits HP1-beta Chromodomain (89125.1 nM), mammalian selenoprotein Thioredoxin Reductase 1 (946.6 nM), ERG Ets/DNA interaction (11220.2 nM), and PLK1-PDB (67015.8 nM). In cell viability assays, compound 705742 shows mixed effects on HEK293T and U2OS cells, with growth rates of 0.0 and 1.0, while consistently inhibiting human fibroblast cells (growth rate of 0.0). Thermal Shift Assays reveal that the compound can both stabilize and destabilize protein structures, indicated by varied Delta TM values. In GPCR beta-arrestin recruitment assays, ICI 204,448 displays both agonistic and inhibitory effects across multiple receptors, including APLNR, C5AR1, FPR2, S1PR1, ADRB2, GPR119, ADGRF1, CX3CR1, FFAR4, ADRA2A, GLP1R, GPR35, and AGTR1, at a concentration of 0.00001. These complex interactions underline the compound’s multifaceted bioactivity and warrant further investigation for its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.
Synonyms	ICI-204448, ICI204448, ICI 204448

Chemical Properties

Molecular Weight	501.83
Formula	C₂₃H₂₇Cl₃N₂O₄
Cas No.	121264-04-8
Smiles	Cl.O=C(O)COC1=CC=CC(=C1)C(N(C(=O)CC2=CC=C(Cl)C(Cl)=C2)C)CN3CCCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9927 mL	9.9635 mL	19.9271 mL	99.6353 mL
5 mM	0.3985 mL	1.9927 mL	3.9854 mL	19.9271 mL
10 mM	0.1993 mL	0.9964 mL	1.9927 mL	9.9635 mL
20 mM	0.0996 mL	0.4982 mL	0.9964 mL	4.9818 mL
50 mM	0.0399 mL	0.1993 mL	0.3985 mL	1.9927 mL
100 mM	0.0199 mL	0.0996 mL	0.1993 mL	0.9964 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc