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ICI 204,448

Name: ICI 204,448
Brand: TargetMol
SKU: T22850
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22850Cas No. 121264-04-8

Alias ICI-204448, ICI204448, ICI 204448

ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.

ICI 204,448

🥰Excellent

Catalog No. T22850Alias ICI-204448, ICI204448, ICI 204448Cas No. 121264-04-8

ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$79	In Stock
10 mg	$125	In Stock
25 mg	$208	In Stock
50 mg	$317	In Stock

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Batch Information

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Purity:>99.99%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.
Synonyms	ICI-204448, ICI204448, ICI 204448

Chemical Properties

Molecular Weight	501.83
Formula	C₂₃H₂₇Cl₃N₂O₄
Cas No.	121264-04-8
Smiles	Cl.O=C(O)COC1=CC=CC(=C1)C(N(C(=O)CC2=CC=C(Cl)C(Cl)=C2)C)CN3CCCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9927 mL	9.9635 mL	19.9271 mL	99.6353 mL
5 mM	0.3985 mL	1.9927 mL	3.9854 mL	19.9271 mL
10 mM	0.1993 mL	0.9964 mL	1.9927 mL	9.9635 mL
20 mM	0.0996 mL	0.4982 mL	0.9964 mL	4.9818 mL
50 mM	0.0399 mL	0.1993 mL	0.3985 mL	1.9927 mL
100 mM	0.0199 mL	0.0996 mL	0.1993 mL	0.9964 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc