proto-oncogene — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0165	Arglabin	(+)-Arglabin	NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.		NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
T8825	Capmatinib 2HCl.H2O	INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O	c-Met/HGFR
	Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.		c-Met/HGFR
T1962	ASP3026	ASP 3026	Apoptosis , ALK
	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.		Apoptosis , ALK
T1963	Capmatinib	NVP-INC280,INC-280,INCB28060	Apoptosis , c-Met/HGFR
	Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.		Apoptosis , c-Met/HGFR
TP2311	C-MYC PEPTIDE EPITOPE TFA		Others
	C-MYC PEPTIDE EPITOPE TFA, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This pe...		Others
T3455	Merestinib	LY2801653	Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase
	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph...
T5S1103	Isoliensinine	Isoliensinin	Apoptosis , Antioxidant
	1. Isoliensinine (Isoliensinin), a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. 2. Isoli...		Apoptosis , Antioxidant
T63790	Cbl-b-IN-3		E1/E2/E3 Enzyme
	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b n...		E1/E2/E3 Enzyme
T31864	FPFS-1169 HCl	R-(-)-BPAP,FPFS 1169,FPFS-1169 hydrochloride,BPAP-cpd,R-FPFS-1169,FPFS1169
	FPFS-1169 (BPAP-CPD, R-(-)-BPAP, R- FpFS-1169) is a proto-oncogene protein C-Bcl-2 stimulant that is one of the "catecholaminergic and serotonergic enhancers" and may be used for the treatment of Parkinson's disease.
T63359	C-Myc inhibitor 4
	c-Myc inhibitor 4 is a potent, orally active c-Myc-reducing compound. c-Myc is an important proto-oncogene, which is closely associated with the development of many tumors.
T81285	RGB-1
	RGB-1, a polycyclic aromatic hydrocarbon, functions as a stabilizer of RNA G-quadruplexes and may inhibit RNA translation while decreasing NRAS proto-oncogene expression in breast cancer cells [1].
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vas...
T72201	Pyridostatin hydrochloride	RR82 hydrochloride
	Pyridostatin (RR82) hydrochloride, a G-quadruplex DNA stabilizing agent (Kd = 490 nM), induces replication- and transcription-dependent DNA damage, promoting growth arrest in human cancer cells. It specifically targets t...
T64072	Cbl-b-IN-2
	Cbl-b-IN-2 is an orally active biological compound that inhibits the E3 enzyme Casitas b lineage lymphoma proto-oncogene b (Cbl-b) in the ubiquitin proteasome pathway and can be used in the study of diseases that modulat...