cox1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7882	Indomethacin farnesil	Infree	Others , COX , Autophagy
	Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).		Others , COX , Autophagy
T12860	SC57666		COX
	SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.		COX
T15571	Imrecoxib	BAP-909	COX
	Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect.		COX
T10355	Apyramide		COX
	Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.		COX
T22346	Indomethacin sodium hydrate	Indometacin sodium hydrate	COX
	Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries,...		COX
T0961	Trometamol	Tromethamine	COX
	Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostagland...		COX
T0159	Pranoprofen	Pyranoprofen	Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
	Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.		Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
T0458	Indomethacin	Indocin,Indometacine,Indomethacine,Indometacin	Phospholipase , COX , PDE , Autophagy
	Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.		Phospholipase , COX , PDE , Autophagy
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T12802	(S)-Ketorolac	(-)-Ketorolac	Others
	(S)-Ketorolac is a potent inhibitor of COX1 and COX2 enzyme, and is nonsteroidal anti-inflammatory agent.		Others
T11655	Indomethacin-D4	Indometacin-D4	CDK
	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.		CDK
T79594	COX-1/2-IN-5		COX
	COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and exhibits anticancer activity by inhibiting liver cancer HepG2...		COX
T70431	TX-1123
	TX-1123 is a potent inhibitor of protein tyrosine kinase (PTK), specifically targeting Src, eEF2-K, PKA, and EGFR-K/PKC. Additionally, it acts as a cyclo-oxygenase (COX) inhibitor, displaying IC50 values of 1.16 μM for C...
T61606	Indomethacin sodium
	Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses n...
T61196	COX-1/2-IN-1
	COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1].
T61865	COX-1/2-IN-2
	COX-1/2-IN-2 is a potent inhibitor of both COX-1 and COX-2, displaying significant inhibitory effects with IC50 values of 9.7 ± 0.09 μM for COX-1 and 4.6 ± 1.45 μM for COX-2, respectively [1].