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Cat No. | Product Name | Synonyms | Targets |
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T80661 | Antihypertensive sulfonanilide XVII | Others | |
Antihypertensive sulfonanilide XVII is an orally available antihypertensive sulfonanilide small molecule compound for the study of hypertension. | |||
T79267 | Antihypertensive agent 3 | ||
Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs) [1]. | |||
T79266 | Antihypertensive agent 2 | ||
Antihypertensive agent 2 (Compound 4g) exhibits effective antagonistic activities against angiotensin II receptor 1 and reduces blood pressure with equal or greater potency than Losartan [1]. | |||
T5471 | GUANABENZ | Adrenergic Receptor | |
GUANABENZ is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanabenz is as an Adrenergic alpha2-Agonist. | |||
T21640 | Talinolol | Adrenergic Receptor | |
(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. | |||
T2519 | Lercanidipine | Masnidipine | Calcium Channel |
Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class. | |||
T0300 | Pargyline | Pargylamine,Paragyline | MAO , Monoamine Oxidase |
Pargyline (Pargylamine) is a monoamine oxidase inhibitor with antihypertensive properties. | |||
T0114 | Trichlormethiazide | Naqua,Metahydrin,Trichlormetazid | ATPase , Carbonic Anhydrase |
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ... | |||
T6641 | Rilmenidine Phosphate | Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor | |
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. | |||
T21957 | Guanabenz hydrochloride | NE56490 | Adrenergic Receptor |
Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects. | |||
T2531 | Eprosartan Mesylate | SKF-108566J | RAAS |
Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker. | |||
T6086 | Clopamide | Brinaldix,Adurix,Aquex | Sodium Channel |
Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity. | |||
T7656 | Apelin-13 | ||
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ... | |||
T0388 | Cilnidipine | FRC-8653 | Calcium Channel |
Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. | |||
T1578 | Pargyline hydrochloride | Pargylamine hydrochloride | MAO , Monoamine Oxidase |
Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties. | |||
T19654 | Guanoclor | VATENSOL | Others |
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. | |||
T1449 | Hydrochlorothiazide | HCTZ | Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad |
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. | |||
T7808 | Alacepril | Cetapril,DU-1219 | RAAS |
Alacepril (DU-1219) is a relatively novel angiotensin-converting enzyme inhibitor, used as an antihypertensive | |||
T2621 | Rostafuroxin | PST 2238 | ATPase , RSV |
Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension. | |||
T0088 | Urapidil hydrochloride | Urapidil HCl | 5-HT Receptor , Adrenergic Receptor |
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. | |||
T22830 | GYY4137 | GYY 4137 morpholine salt | Others |
GYY4137 (GYY 4137 morpholine salt) is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity. | |||
T1613 | Hydralazine hydrochloride | Hydralazine HCl,Apresoline | MAO , HIF/HIF Prolyl-Hydroxylase |
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an... | |||
T4574 | Sacubitril | AHU 377,AHU377,AHU-377 | Neprilysin |
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. | |||
T1461 | Candesartan | CV 11974 | RAAS |
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. | |||
T0119 | Nitrendipine | BAY-E-5009,Bayotensin | Calcium Channel , Autophagy |
Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtr... | |||
T6874 | Lercanidipine hydrochloride | Corifeo,Carmen,Cardiovasc | Calcium Channel |
Lercanidipine hydrochloride (Corifeo) is a calcium channel blocker of the dihydropyridine class. | |||
T8315 | 1-Cyclohexyl-3-dodecyl urea | CDU,N-Cyclohexyl-N-dodecyl urea,NCND | Epoxide Hydrolase |
1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. | |||
T12478L | Pinacidil | S 1230,P 1134,S-1230,P-1134,P1134 | Potassium Channel |
Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention. | |||
T10511 | Anti-hypertensive sulfonanilide 1 | Others | |
Anti-hypertensive sulfonanilide 1 is an antihypertensive compound. | |||
T3518 | GSK269962A | GSK269962B,GSK 269962,GSK269962A HCl | ROCK , S6 Kinase |
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. | |||
T1462 | Captopril | SQ 14225,SQ-14534,SA333 | RAAS |
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. | |||
T6542 | Imidapril hydrochloride | Novaloc,Imidapril HCl,Tanapril,TA-6366 | RAAS |
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. | |||
T0342 | Carvedilol phosphate hemihydrate | Carvedilol phosphate,BM 14190 (phosphate hemihydrate) | VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy |
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom... | |||
T23044 | N,N'-Dicyclohexylurea | DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 | Epoxide Hydrolase |
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. | |||
T6595 | Moexipril hydrochloride | Moexipril HCl,RS-10085,SPM 925,CI-925 | Apoptosis , RAAS |
Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure. | |||
T11109 | DU717 | DU-717 | Others |
DU717 is an antihypertensive agent. | |||
T25828 | Monatepil maleate | AJ2615,AJ 2615,AJ-2615 | |
Monatepil maleate is an Antihypertensive agent. It is a calcium antagonist with alpha(1)-adrenergic receptor blocking activity | |||
T3270 | Dihydralazine sulfate | 1,4-Dihydrazinophthalazine sulfate,Hydralazine sulfate,Nepresol,Depressan,Dihydralazine sulphate | Others |
Dihydralazine sulfate (Nepresol) is an antihypertensive agent. | |||
T5964 | Olmesartan | CS 088,RNH 6270 | RAAS |
Olmesartan (RNH 6270) is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity. | |||
T10683 | Carmoxirole hydrochloride | EMD 45609 hydrochloride | Dopamine Receptor |
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo. | |||
T17266 | Xipamide | Diurexan,Aquaphor | Others |
Xipamide (Diurexan) is a sulfonamide-based diuretic with antihypertensive properties. Xipamide selectively inhibits anion exchanger. | |||
T7686 | Ramiprilat | RAAS | |
Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. | |||
T15553 | Iganidipine | NKY 722 | Calcium Channel |
Iganidipine(NKY 722) is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases. | |||
T12478 | Pinacidil monohydrate | Potassium Channel | |
Pinacidil monohydrate is a potassium channel activator, antihypertensive drug. | |||
T26923 | Bunazosin Hydrochloride | E 1015,E643,E-1015,E-643,E 643 | Adrenergic Receptor |
Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug. | |||
T26939 | Cadralazine | ISF 2469,ISF-2469,ISF2469 | Others |
Cadralazine (ISF 2469) is a peripheral arteriolar vasodilator and can be used in studies about acting as an antihypertensive drug. | |||
T1007 | Nanofin | Lupetidine,Lupetidin,2,6-Lupetidine,2,6-Dimethylpiperidine,Naniopinum | AChR |
Nanofin (Lupetidine) is a neuropathic blocker, with antihypertensive effect. | |||
T1605 | Enalapril | MK-421 | RAAS , MRP |
Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. | |||
T1520 | Aliskiren hemifumarate | CGP 60536,SPP 100,CGP60536B | RAAS , Autophagy |
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. | |||
T6635 | EMD638683 | SGK | |
EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8270 | Deserpidine | Harmonyl | RAAS |
Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie... | |||
TN1733 | Hesperetin 7-O-glucoside | Anti-infection , Antibacterial , HMG-CoA Reductase | |
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh... | |||
TN1644 | Flavanomarein | Others | |
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea... | |||
TN1911 | Marein | transporter , Akt , HDAC , AMPK | |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... | |||
T2939 | Forskolin | Coleonol,Colforsin | FXR , Adenylyl cyclase , AChR , Autophagy |
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the... | |||
T5S0106 | Peimisine | Ebeiensine | RAAS , AChR |
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... | |||
TN1142 | 8-Oxocoptisine | 8-Oxycoptisine | Others |
8-Oxocoptisine (8-Oxycoptisine) is a natural product with Anti-inflammatory, analgesic, cooling, antihypertensive, anti-cancer | |||
T6S0535 | Pinoresinol diglucoside | Pinoresinol Diglucopyranoside | Glucosidase |
1. Pinoresinol diglucoside (Pinoresinol Diglucopyranoside) is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound. | |||
T19768 | γ-Tocotrienol | gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol | Others |
γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo. | |||
T1035 | Hesperidin | Hesperetin 7-rutinoside,Cirantin | Apoptosis , Reactive Oxygen Species , Endogenous Metabolite , Autophagy |
Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. | |||
T0505 | Methyldopa | L-(-)-α-Methyldopa,MK-351 | Dopamine Receptor , Adrenergic Receptor |
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. | |||
T8061 | Citronellal | (±)-Citronellal | Others |
Citronellal ((±)-Citronellal) is a monoterpene predominantly formed by the secondary metabolism of plants, producing antithrombotic, antiplatelet, and antihypertensive activities. | |||
T4S0792 | Pinoresinol 4-O-β-D-glucopyranoside | (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside | Others |
(+)-Pinoresinol-β-D-glucoside, also known as (+)-pinor, is a major active lignan furanoid found in Forsythia. It exhibits antioxidative, antihypertensive activities, and acts as an inhibitor of cyclic adenosine monophosp... | |||
T6926 | Palmitoylethanolamide | Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol | Influenza Virus , Endogenous Metabolite , PPAR |
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth... | |||
T1286 | Vincamine | Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval | GPR , Others |
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. | |||
T0883 | Tramiprosate | Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed | Beta Amyloid , GABA Receptor |
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB... | |||
TN4883 | Quinine sulfate dihydrate | Others | |
Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassiu... | |||
T64744 | Ovalbumins | Endogenous Metabolite | |
Ovalbumins is the main protein found in egg whites. Ovalbumins have various biological activities such as antibacterial, anticancer, antihypertensive, antioxidant and immunomodulatory activities. Ovalbumins are the most ... | |||
T0791 | Reserpine | Serpalan,Serpasil,Serpivite | Others , Potassium Channel , MRP , Monoamine Transporter , Autophagy |
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotoni... | |||
T4S1637 | Gamma-Mangostin | Normangostin | Others , 5-HT Receptor |
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ... | |||
TN6007 | Serpentinine | ||
Serpentinine may have antihypertensive effect. | |||
TN1826 | Kaempferol-4'-O-beta-D-glucopyranoside | Others | |
Kaempferol-4'-O-beta-D-glucopyranoside is an antihypertensive agent. | |||
T19911 | Rescinnamine | Anaprel,Apoterin S,Apoterin | |
Rescinnamine is an inhibitor of angiotensin-converting enzyme. It also is a vinca alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. It used as an antihypertensive drug. | |||
TN5645 | Isomartynoside | ||
Isomartynoside has inhibition against the angiotensin converting enzyme (ACE) activities, the IC 50 value is 505±26.7μg/ml, it may have antihypertensive effect. Isomartynoside also shows obvious anti-fatigue activity. | |||
TN1367 | Alismol | Potassium Channel , Calcium Channel , PI3K | |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. | |||
TN1577 | Dicentrine | Others | |
Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain. | |||
TN4936 | Salvisyrianone | ||
Salvisyrianone is a diterpene isolated from Cryptomeria taiwanensis and S. syriacus with potential antihypertensive activity and antitumor activity. | |||
TN4431 | Leucosceptoside A | RAAS , PKC | |
Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidase. Leucosceptoside A has antihypertensive effect, it shows ... | |||
T83562 | (2R)-Flavanomarein | ||
'(2R)-Flavanomarein, a major flavonoid from Coreopsis tinctoria Nutt, exhibits protective effects against diabetic nephropathy and possesses antioxidative, antidiabetic, antihypertensive, and anti-hyperlipidemic properti... | |||
TN1681 | Gentianine | Others , TNF , transporter , PPAR | |
Gentianine is an effective Swertiamarin derivative, which has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, diuretic and other effects, and has the potential to be developed into a safe antihypertensive d... |
Cat No. | Product Name | ||
---|---|---|---|
L6820 | Tobacco Monomer Library | 750 compounds | |
A unique collection of 750 tobacco monomer compounds for high throughput screening and high content screening; |