Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Serine Protease

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes.

  • Leupeptin Hemisulfate
    T6564103476-89-7
    Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.
    • $47
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • AEBSF hydrochloride
    T637030827-99-7
    AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Amiloride hydrochloride
    T01752016-88-8
    Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial.
    • $15
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Ceritinib
    T17911032900-25-6
    Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
    • $45
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • PMSF
    T0789329-98-6
    Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
    • $33
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Patamostat HCl
    T9670L3031765-17-7In house
    Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.
    • $195
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
    T880280499-32-7
    2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or synthetically produced.
    • $79
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • KKI-5 acetate(97145-43-2 free base)
    TP1792L
    KKI-5 acetate is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.
    • $71
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
    T85631234707-32-4
    2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.
    • $79
    In Stock
    Size
    QTY
  • BMS-363131
    T30519384829-65-6In house
    BMS-363131 (BMS363131) is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
    • $78
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • 2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE
    T860213947-21-2
    2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).
    • $50
    In Stock
    Size
    QTY
  • Pirodomast
    T67959108310-20-9In house
    Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospasm induced by histamine, methacholine, serotonin, LTC4, or platelet-activating factor. Pirodomast is a potential antiallergic compound. Pirodomast had only weak relaxant activity on guinea pig trachea in vitro. Pirodomast is a potential antiallergic compound that inhibits the protein hydrolyzing activity of trypsin in vitro, prevents antigen-induced immediate and late asthmatic responses in allergic sheep in vivo, and inhibits antigen-induced airway hyperresponsiveness to histamine and carbachol in allergic sheep.
    • $162
    In Stock
    Size
    QTY
  • BCX 1470 hydrochloride
    T13568L In house
    BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor D and C1s, and can be used to study oedema.
    • $139
    In Stock
    Size
    QTY
  • BCX 1470
    T13568217099-43-9In house
    BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
    • $1,520
    Backorder
    Size
    QTY
  • 3,4 Dichloroisocoumarin
    T867751050-59-0
    3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
    • $38
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Aprotinin
    T33599087-70-1
    Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • GSK-690693
    T6285937174-76-0
    GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
    • $41
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Nafamostat mesylate
    T239282956-11-4
    Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • ZD-0892
    T13389171964-73-1
    ZD-0892 is a selective and potent inhibitor of neutrophil elastase, inhibits human neutrophil elastase and porcine pancreatic elastase, reverses advanced pulmonary vascular disease produced in rats, and can be used to study chronic obstructive pulmonary disease (COPD) and peripheral vascular disease (PVD).
    • $119
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
    TN4005613684-55-2
    erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether is a compound extracted from Brazilian rubber seed hulls and is an inhibitory activity against human leukocyte elastase (IC50 : 171 umol/L).
    • $2,289
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Secologanoside
    TN102259472-23-0
    Secologanoside shows anti-complementary, allelopathic, and anti-elastase activities.
    • $89
    In Stock
    Size
    QTY
  • ZT-12-037-01
    T55972328073-61-4
    Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
    • $30
    In Stock
    Size
    QTY
  • BAY-85-8501
    T12613L1161921-82-9
    BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)
    • $88
    In Stock
    Size
    QTY
  • ZK824190
    T134082254001-81-3
    ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).
    • $272
    In Stock
    Size
    QTY
  • FK706
    T15285144055-55-0
    FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef
    • $1,530
    Backorder
    Size
    QTY
  • MEGA-9
    T2099285261-19-4
    MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.
    • $50
    In Stock
    Size
    QTY
  • 4-Aminobenzamidine dihydrochloride
    T602482498-50-2
    4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2].
    • $42
    In Stock
    Size
    QTY
  • ML281
    T34231404437-62-2
    ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
    • $37
    In Stock
    Size
    QTY
  • Alpha-Amyrin
    TN1372638-95-9
    Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.
    • $129
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Sivelestat
    T6986127373-66-4
    Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
    • $42
    In Stock
    Size
    QTY
  • UK-371804 HCl
    T22451256476-36-5
    UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fold versus plasmin and 4000-fold versus tPA).
    • $1,520
    Backorder
    Size
    QTY
  • Upamostat
    T13257590368-25-5
    Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
    • $97
    In Stock
    Size
    QTY
  • JCP174
    T25549126062-19-9
    JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.
    • $154
    In Stock
    Size
    QTY
  • ZM223 hydrochloride (2031177-48-5 free base)
    T13412L
    ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
    • $398
    Backorder
    Size
    QTY
  • BCX 1470 methanesulfonate
    T13567217099-44-0
    BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
    • $1,080
    Backorder
    Size
    QTY
  • Sivelestat sodium tetrahydrate
    T20762201677-61-4
    Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
    • $42
    In Stock
    Size
    QTY
  • AA26-9
    T39901312782-34-5
    AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
    • $31
    In Stock
    Size
    QTY
  • Diminazene Aceturate
    T1145908-54-3
    Diminazene is a trypanocidal agent.
    • $42
    In Stock
    Size
    QTY
  • Gabexate mesylate
    T037256974-61-9
    Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
    • $51
    In Stock
    Size
    QTY
  • SC-514
    T2118354812-17-2
    SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • UK-371804
    T3442256477-09-5
    UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
    • $44
    In Stock
    Size
    QTY
  • Chrysophanol 8-O-glucoside
    T3S038113241-28-6
    Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway
    • $76
    In Stock
    Size
    QTY
  • (R)-3-hydroxy Myristic Acid
    T3804128715-21-1
    (R)-3-hydroxy Myristic Acid is an antifungal compound from Lactobacillus plantarum MiLAB 14 with antioxidant, anti-elastase, and anti-urease activities and can be used in the study of fungal infections.
    • $71
    In Stock
    Size
    QTY
  • BC 11 hydrobromide
    T22600443776-49-6
    BC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.
    • $81
    In Stock
    Size
    QTY
  • AE-3763
    T10254291778-77-3
    AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
    • $1,190
    Backorder
    Size
    QTY
  • PF-3644022
    T165011276121-88-0
    PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated
    • $119
    In Stock
    Size
    QTY
  • ZD8321
    T17288182073-77-4
    ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
    • $1,520
    Backorder
    Size
    QTY
  • Alvelestat
    T3107848141-11-7
    Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
    • $30
    In Stock
    Size
    QTY
  • Demethylwedelolactone
    T5S06896468-55-9
    Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Benzamidine hydrochloride
    T83621670-14-0
    Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
    • $40
    In Stock
    Size
    QTY