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Serine Protease

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes.
Cat. No. Product name CAS No. Purity Chemical Structure
T67959 Pirodomast 108310-20-9 98%
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
T30519 BMS-363131 384829-65-6 98%
BMS-363131 is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
T10254 AE-3763 291778-77-3 98%
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T22451 UK-371804 HCl 256476-36-5 98%
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
T15285 FK706 144055-55-0 98%
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
T17288 ZD8321 182073-77-4 98%
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T13568 BCX 1470 217099-43-9 98%
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
T13567 BCX 1470 methanesulfonate 217099-44-0 98%
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
T13412L ZM223 hydrochloride (2031177-48-5 free base) T13412L 98%
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T13393 ZEN-3411 1952264-36-6 98%
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
T8362 Benzamidine hydrochloride 1670-14-0 98%
Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
T8677 3,4 Dichloroisocoumarin 51050-59-0 98%
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
T2118 SC-514 354812-17-2 98%
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T3107 Alvelestat 848141-11-7 98%
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
T5S0689 Demethylwedelolactone 6468-55-9 98%
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on ...
T3423 ML281 1404437-62-2 98%
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
T20762 Sivelestat sodium tetrahydrate 201677-61-4 98%
Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetra...
T0372 Gabexate mesylate 56974-61-9 98%
Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
T1791 Ceritinib 1032900-25-6 98%
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T60248 4-Aminobenzamidine dihydrochloride 2498-50-2 98%
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uP...
Pirodomast
T67959
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
BMS-363131
T30519
BMS-363131 is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
AE-3763
T10254
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
UK-371804 HCl
T22451
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
FK706
T15285
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
ZD8321
T17288
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
BCX 1470
T13568
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
BCX 1470 methanesulfonate
T13567
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
ZM223 hydrochloride (2031177-48-5 free base)
T13412L
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
ZEN-3411
T13393
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
Benzamidine hydrochloride
T8362
Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
3,4 Dichloroisocoumarin
T8677
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
SC-514
T2118
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Alvelestat
T3107
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
Demethylwedelolactone
T5S0689
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on ...
ML281
T3423
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
Sivelestat sodium tetrahydrate
T20762
Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetra...
Gabexate mesylate
T0372
Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
Ceritinib
T1791
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
4-Aminobenzamidine dihydrochloride
T60248
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uP...
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