T67959 |
Pirodomast
|
108310-20-9
|
98%
|
|
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
|
T30519 |
BMS-363131
|
384829-65-6
|
98%
|
|
BMS-363131 is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
|
T10254 |
AE-3763
|
291778-77-3
|
98%
|
|
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
|
T22451 |
UK-371804 HCl
|
256476-36-5
|
98%
|
|
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
|
T15285 |
FK706
|
144055-55-0
|
98%
|
|
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
|
T17288 |
ZD8321
|
182073-77-4
|
98%
|
|
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
|
T13568 |
BCX 1470
|
217099-43-9
|
98%
|
|
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
|
T13567 |
BCX 1470 methanesulfonate
|
217099-44-0
|
98%
|
|
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
|
T13412L |
ZM223 hydrochloride (2031177-48-5 free base)
|
T13412L
|
98%
|
|
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
|
T13393 |
ZEN-3411
|
1952264-36-6
|
98%
|
|
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
|
T8362 |
Benzamidine hydrochloride
|
1670-14-0
|
98%
|
|
Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
|
T8677 |
3,4 Dichloroisocoumarin
|
51050-59-0
|
98%
|
|
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
|
T2118 |
SC-514
|
354812-17-2
|
98%
|
|
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
|
T3107 |
Alvelestat
|
848141-11-7
|
98%
|
|
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
|
T5S0689 |
Demethylwedelolactone
|
6468-55-9
|
98%
|
|
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on ...
|
T3423 |
ML281
|
1404437-62-2
|
98%
|
|
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
|
T20762 |
Sivelestat sodium tetrahydrate
|
201677-61-4
|
98%
|
|
Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetra...
|
T0372 |
Gabexate mesylate
|
56974-61-9
|
98%
|
|
Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
|
T1791 |
Ceritinib
|
1032900-25-6
|
98%
|
|
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
|
T60248 |
4-Aminobenzamidine dihydrochloride
|
2498-50-2
|
98%
|
|
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uP...
|