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Serine Protease

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes.
Cat. No. Product name CAS No. Purity Chemical Structure
T13393 ZEN-3411 1952264-36-6 98%
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
T13412L ZM223 hydrochloride (2031177-48-5 free base) T13412L 98%
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T13567 BCX 1470 methanesulfonate 217099-44-0 98%
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
T13568 BCX 1470 217099-43-9 98%
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
T17288 ZD8321 182073-77-4 98%
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T15285 FK706 144055-55-0 98%
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
T22451 UK-371804 HCl 256476-36-5 98%
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
T10254 AE-3763 291778-77-3 98%
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T20992 MEGA-9 85261-19-4 98%
MEGA-9 solubilizes membrane protein and can be used as a nonionic detergent.
T13408 ZK824190 2254001-81-3 98%
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 16...
T3359 Aprotinin 9087-70-1 98%
Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
T3990 AA26-9 1312782-34-5 98%
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
T8602 2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE 13947-21-2 98%
2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).
T5597 ZT-12-037-01 2328073-61-4 98%
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
T6564 Leupeptin Hemisulfate 103476-89-7 98%
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
TN1372 Alpha-Amyrin 638-95-9 98%
Alpha-Amyrin is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.
T25549 JCP174 126062-19-9 98%
JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.
T8802 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- 80499-32-7 98%
Trypsin inhibitor (human urine urinastatin protein moiety), as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or...
T12613L BAY-85-8501 1161921-82-9 98%
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)
T6285 GSK-690693 937174-76-0 98%
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
ZEN-3411
T13393
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
ZM223 hydrochloride (2031177-48-5 free base)
T13412L
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
BCX 1470 methanesulfonate
T13567
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
BCX 1470
T13568
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
ZD8321
T17288
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
FK706
T15285
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
UK-371804 HCl
T22451
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
AE-3763
T10254
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
MEGA-9
T20992
MEGA-9 solubilizes membrane protein and can be used as a nonionic detergent.
ZK824190
T13408
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 16...
Aprotinin
T3359
Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
AA26-9
T3990
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE
T8602
2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).
ZT-12-037-01
T5597
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Leupeptin Hemisulfate
T6564
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
Alpha-Amyrin
TN1372
Alpha-Amyrin is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.
JCP174
T25549
JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.
2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
T8802
Trypsin inhibitor (human urine urinastatin protein moiety), as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or...
BAY-85-8501
T12613L
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)
GSK-690693
T6285
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
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