Serine Protease

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes.

Cat. No.	Product name	CAS No.	Purity
T67959	Pirodomast	108310-20-9	98%
T67959	Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
T30519	BMS-363131	384829-65-6	98%
T30519	BMS-363131 is a potent and selective trypsin inhibitor with an IC50 value of <1.7 nM.
T10254	AE-3763	291778-77-3	98%
T10254	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T22451	UK-371804 HCl	256476-36-5	98%
T22451	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fol...
T15285	FK706	144055-55-0	98%
T15285	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine ...
T17288	ZD8321	182073-77-4	98%
T17288	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T13568	BCX 1470	217099-43-9	98%
T13568	BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
T13567	BCX 1470 methanesulfonate	217099-44-0	98%
T13567	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respecti...
T13412L	ZM223 hydrochloride (2031177-48-5 free base)	T13412L	98%
T13412L	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T13393	ZEN-3411	1952264-36-6	98%
T13393	ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs to...
T8362	Benzamidine hydrochloride	1670-14-0	98%
T8362	Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively).
T8677	3,4 Dichloroisocoumarin	51050-59-0	98%
T8677	3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
T2118	SC-514	354812-17-2	98%
T2118	SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T3107	Alvelestat	848141-11-7	98%
T3107	Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
T5S0689	Demethylwedelolactone	6468-55-9	98%
T5S0689	Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on ...
T3423	ML281	1404437-62-2	98%
T3423	ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
T20762	Sivelestat sodium tetrahydrate	201677-61-4	98%
T20762	Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetra...
T0372	Gabexate mesylate	56974-61-9	98%
T0372	Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
T1791	Ceritinib	1032900-25-6	98%
T1791	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T60248	4-Aminobenzamidine dihydrochloride	2498-50-2	98%
T60248	4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uP...