h-8

H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.

H-89 is a selective and potent protein kinase A inhibitor (IC50: 48 nM), a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.

ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

ZXH-8-004 (2-12-2-deg) is a potent degrader of DENV EPROTAC, with a DC50 of 0.21 µM. Additionally, ZXH-8-004 exhibits antiviral activity.

IDPH-8261 is an orally active nonsteroidal anti-inflammatory drug (NSAID). It is applicable for research related to inflammation, such as in studies of arthritis.

RGH-857 is an orally active, selective, and potent positive allosteric modulator of nicotinic α7 receptors. RGH-857 enhances α7 receptor function and is utilized in neuroscience research focused on cholinergic neurotransmission, cognitive function modulation, and receptor allosteric regulation in Alzheimer’s disease–related experimental models.

H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a selective inhibitor of cAMP-dependent protein kinase A (PKA) with an IC50 value of 48 nM. It also mildly inhibits PKG, PKC, and casein kinase activity. H-89 dihydrochloride can be used in research areas such as cell proliferation, apoptosis, metabolism, neurotransmission, and endocrine regulation.

IMB-YH-8 is an inhibitor of protein kinase B (PknB), inhibiting PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner.

H-87 is a protein kinase inhibitor and vasodilator.

AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation of Munc13-1 from the cytoplasm to the plasma membrane. It is utilized in neurodegenerative disease research [1].

DH-8P-DB, an anticancer candidate, exhibits cytotoxicity against colon cancer cells [1].

p-Menth-8-ene-1,2-diol is a natural product for research related to life sciences. The catalog number is TN4729 and the CAS number is 57457-97-3.

(±)-Prenalterol (H 80/62) is a new cardioselective positive inotropic compound that is an agonist of beta-2- and beta-1-adrenergic receptors and can be used to study chronic congestive heart failure.

Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.

DSPS (Dioctadecanoylphosphatidylserine) is a glycerophospholipid, an important phospholipid membrane component that plays a key role in cell cycle signaling. DSPS can regulate cellular activity and mediate apoptosis. DSPS is widely used as a nutritional supplement.

Norgestrel (WY-3707) is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.

ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.

IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).

LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.

AH 8532 is an opioid compound with analgesic effects and is effective in inhibiting the quinone-induced writhing response in mice, with an oral ED50 of 16 mg/kg.

AH 8529 is an orally active opioid compound with analgesic properties.

Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.

ZH8965 is an orally active TAAR1-Gs/Gq agonist (EC50: 6.1/14.8 nM) that shows efficacy in alleviating antipsychotic-like phenotypes and cognitive deficits in an MK-801-induced psychosis model in mice. It is applicable for research related to schizophrenia.