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Results for "

pa-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    38
    TargetMol | Inhibitors_Agonists
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Pediocin PA 1
TP2614111745-56-3
Pediocin PA-1, a broad-spectrum lactic acid bacterial bacteriocin, inhibits the activity of foodborne pathogens including Listeria monocytogenes and Gram-positive bacteria, and can be utilized as a food biopreservative [1].
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18:0-18:1 PA sodium
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate sodium, 18:0-18:1 PA sodium
T205426384833-24-3
18:0-18:1 PA (1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate) sodium is an anionic lipid.
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1-Palmitoyl-2-Oleoyl-sn-glycero-3-PA
1-Palmitoyl-2-Oleoyl-sn-glycero-3-Phosphatidic Acid,16:0-18:1 PA,1-Hexadecanoyl-2-Octadecanoyl-sn-glycero-3-phosphatidic Acid,1-Hexadecanoyl-2-Octadecenoyl-sn-glycero-3-phosphate,1-Palmitoyl-2-Oleoyl-sn-glycero-3-phosphate,16:0 18:1-PA,1-Hexadecanoyl-2-Octadecenoyl-sn-glycero-3-PA,PA(16:0 18:1),1,2-POPA
T8437662600-81-1
1-Palmitoyl-2-oleoyl-sn-glycero-3-PA (1,2-POPA) is a phospholipid featuring a palmitic acid (16:0) chain that is saturated and an oleic acid (18:1) chain that is monounsaturated, positioned at the sn-1 and sn-2 locations, respectively. This compound is utilized in creating micelles, liposomes, and various artificial membrane forms.
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8-10 weeks
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1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA
1-Hexadecanoyl-d9-2-hydroxy-sn-glycero-3-phosphate
T849952830282-77-2
1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.
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Pediocin PA 1 TFA
TP2902
Pediocin PA 1 TFA is a broad-spectrum bacteriocin produced by lactic acid bacteria, inhibiting the activity of foodborne pathogens such as Listeria monocytogenes and other Gram-positive bacteria. It has applications as a biopreservative in food products.
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FPA-124
FPA124, Akt Inhibitor XI
T11317902779-59-3
FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor interacting with the homology (PH) and kinase structural domains of Akt to induce apoptosis. It has the advantage of being highly potent and exhibits dose-dependent growth inhibition in a variety of cancer cell lines.
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7-10 days
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HPA-12
T71843383418-30-2
HPA-12 is a novel potent inhibitor of cert, binding to the ceramide-binding pocket in the cert start domain
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6-8 weeks
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GPA-1734 bromide
T6982721852-25-5
GPA-1734 bromide is an inhibitor of basement membrane collagen synthesis and angiogenesis.
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6-8 weeks
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mtor/hdac-in-1
T633992815286-02-1In house
mTOR HDAC-IN-1 (Compound 50) is a dual inhibitor of mTOR and HDAC, with IC50 values of 0.49 nM and 0.91 nM, respectively, holding potential as an anti-cancer agent [1].
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3-6 months
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cyclophosphamide
T0707L50-18-0
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
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7-10 days
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TargetMol | Citations Cited
Bencycloquidium Bromide
BCQB
T26770860804-18-8In house
Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M(1) pKi=7.86, M(2) pKi=7.21, M(3) pKi=8.21); pA(2)=8.85, 8.71 and 8.57 in methacholine-induced contraction of trachea, ileum and urinary bladder, 8.19 in methacholine-induced bradycardia of right atrium in vitro, respectively.This compound is unstable in powder form and other related salt forms are recommended.
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3-6 months
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U-73343
U 73343
TQ0159142878-12-4
U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Paclitaxel-SMCC
SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate.
T28289
Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies, antigens and other biopolymers. Pa
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Pomalidomide-CO-C5-azide
T872362227423-33-6
Compound PA, also known as Pomalidomide-CO-C5-azide, serves as a ligand for E3 ligase and features a bioorthogonal azide group. This compound is utilized in the synthesis of PROTACs that exhibit anticancer properties [1].
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AM-Imidazole-PA-Boc
T173882357108-99-5
AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker used for the synthesis of PROTAC IRAK4 degrader-1[1].
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ATP synthase inhibitor 2 TFA
T79004
ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg mL. It effectively halts ATP synthesis in Pseudomonas aeruginosa at a concentration of 128 μg mL [1].
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FAK-IN-3
T63545
FAK-IN-3 is a potent inhibitor of adherens spot kinase (FAK). FAK-IN-3 reduces migration and invasion of PA-1 cells and inhibits the expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis with no significant adverse effects. FAK-IN-3 has shown investigational potential in ovarian cancer.
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10-14 weeks
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ATP synthase inhibitor 2
T616492814540-76-4
ATP Synthase Inhibitor 2, a compound targeting Pseudomonas aeruginosa (PA) ATP synthase with an IC50 of 10 μg mL, fully inhibits the ATP synthesis activity of PA at a concentration of 128 μg mL [1].
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10-14 weeks
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Gremubamab
T770291800381-36-5
Gremubamab (MEDI3902), a humanized IgG1 kappa anti-PcrV Psl monoclonal antibody, specifically targets and binds to the Pseudomonas aeruginosa PcrV protein and Psl exopolysaccharide. It shows promise for the study of Pseudomonas aeruginosa infections [1] [2].
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2-4 weeks
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Bevirimat
YK FH312, MPC-4326, PA-457
T5782174022-42-5
Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.
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TargetMol | Inhibitor Sale
1-Linoleoyl Lysophosphatidic Acid sodium
1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,LPA(18:2),PA(18:2(9Z,12Z) 0:0),1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate,18:2 Lyso PA,1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA,PA(18:2 0:0),1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate,1-Linoleoyl LPA
T8377272777-86-7
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone 2472 tumors, while its plasma levels are reduced in primary progressive multiple sclerosis patients—unlike in those with relapsing-remitting multiple sclerosis—and inversely associate with the severity of neurological deficits.
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AMPK activator 15
T201627
AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.
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PA1 2HCl
PA1 dihydrochloride, PA1
T282871620951-72-5
PA1 2HCl is a blocker of photoswitchable epithelial sodium channel (ENaC). PA1 2HCl enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light.
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6-8 weeks
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SA-PA
T79530
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-PA undergoes in situ conversion to active PROTAC through a click reaction [1].
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