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TRPV4/TRPA1-IN-1
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Catalog No. T217898 Copy Product Info
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TRPV4/TRPA1-IN-1 is an inhibitor of TRPV4/TRPA1 that blocks calcium influx mediated by these channels. It alleviates pain behaviors in a mouse model of trigeminal stimulation pain and reduces inflammation and pain-related behaviors in a mouse model of acute pancreatitis. TRPV4/TRPA1-IN-1 is useful for the study of acute pancreatitis.
TRPV4/TRPA1-IN-1
Cas No. 1532515-60-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TRPV4/TRPA1-IN-1 is an inhibitor of TRPV4/TRPA1 that blocks calcium influx mediated by these channels. It alleviates pain behaviors in a mouse model of trigeminal stimulation pain and reduces inflammation and pain-related behaviors in a mouse model of acute pancreatitis. TRPV4/TRPA1-IN-1 is useful for the study of acute pancreatitis. |
| Targets & IC50 | TRPV4 (rat):0.45 μM |
| In vitro | TRPV4-IN-4 (0-10 μM) inhibits TRPV4-mediated Ca 2+ influx in TRPV4-overexpressing N2a cells, primary pig articular chondrocytes, and primary rat astrocytes, with an IC 50 of 0.45 μM in N2a cells. TRPV4-IN-4 (5 μM; 5 minutes) effectively suppresses TRPV4-mediated transmembrane currents in N2a cells expressing TRPV4-GFP+. It also inhibits TRPA1 activity in TRPA1-overexpressing N2a cells, with an IC 50 of 0.43 μM. |
| In vivo | TRPV4-IN-4 (10 mg/kg; i.p.; single dose) alleviates trigeminal neurogenic pain mediated by TRPV4 and TRPA1 in mouse pain models. Additionally, TRPV4-IN-4 (10 mg/kg; intraperitoneal injection; single dose) reduces inflammation and pain associated with Caerulein-induced acute pancreatitis models, effectively eliminating pancreatic edema and pain behaviors. |
| Molecular Weight | 399.55 |
| Formula | C25H25N3S |
| Cas No. | 1532515-60-8 |
| Smiles | N1=C(SC=C1C=2C=CC=CC2)NC3=CC=C(C=C3)CCN(C)CC=4C=CC=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: TRPV4/TRPA1-IN-1 in vivo | TRPV4/TRPA1-IN-1 in vitro | TRPV4/TRPA1-IN-1 formula | TRPV4/TRPA1-IN-1 molecular weight
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