m5

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is an IgG2b antibody inhibitor derived from rats, specifically targeting mouse MHC Class II.

DC_M5_2 is a novel inhibitor of wdr5-mll1 interaction

VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.

VU 6008667 is a selective negative allosteric modulator (NAM) of the M5 receptor, with IC50 values of 1.2 μM for human M5 and 1.6 μM for rat M5.

VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM).

Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist.

Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.

Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).

Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster and more consistent inhibition on ADP-receptors. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).

Urolithin M5 (Decarboxyellagic acid) is a neuraminidase inhibitor isolated from olive leaves with antiviral and anticancer and antitumor activities. Urolithin M5 can be used to study influenza A virus infection and SARS-CoV-2 infection.

Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) is a rat-derived IgG2a antibody inhibitor targeting mouse Thy1/CD90.

M5 glycan (Man5), 2-AA labelled (Mannose-5 N-linked oligosaccharide, 2-AA labelled; Oligomannose 5 glycan, 2-AA labelled) is a type of N-linked glycoprotein that acts as a versatile fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antenna structures of N-glycans.

M5 glycan (Man5), 2-AB labelled (Mannose-5 N-linked oligosaccharide, 2-AB labelled; Oligomannose 5 glycan, 2-AB labelled) is a type of polymeric N-glycoprotein that serves as a versatile fluorescent linker. The resulting conjugate mimics the antenna components of N-glycans, offering high sensitivity and specificity.

M5 glycan (Man5), APTS labelled (Mannose-5 N-linked oligosaccharide, APTS labelled; Oligomannose 5 glycan, APTS labelled), is a multifunctional fluorescent linker, characterized as a polymeric N-glycoprotein. The resulting conjugate exhibits high sensitivity and specificity by mimicking the antenna structure of N-glycans.

M5 glycan (Man5) (Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan) is a polymeric N-glycoprotein that serves as a versatile fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennae elements of N-glycans.

M5 glycan (Man5), procainamide labelled (Mannose-5 N-linked oligosaccharide, procainamide labelled; Oligomannose 5 glycan, procainamide labelled) is a multifunctional fluorescent linker that acts as a poly-N-glycoprotein. The resultant conjugate exhibits high sensitivity and specificity by mimicking the antenna-like elements of N-glycans.

HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.

(Rac)-VU 6008667 is a selective negative allosteric modulator of the muscarinic acetylcholine receptor subtype 5 (M5 NAM), with an IC50 of 1.8 μM and a pIC50 of 5.75, exhibiting high CNS penetration.

CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.

CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.

BDBM50597431 is an NMDA receptor modulator that may have can be used to study Alzheimer's disease and Parkinson's syndrome.