labeling

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

Sodium Glucoheptonate is used as a kit for Tc-99m radiolabeling, as well as for metal cleaning, mercerizing, paint stripping and aluminum etching. Among other things, Tc-99m glucoheptonate is a kidney and brain imaging agent that can be used to detect brain tumors.

5-hydroxy-1-tetralone as the fluorescent labeling reagent.

Biotin-azide is a click chemistry reagent serving as a biotin labeling tool containing a terminal azide group. Biotin-azide is utilized to prepare various biotinylated conjugates via Click Chemistry and participates in the identification of newly synthesized proteins.

O-Propargyl-Puromycin ( OP-puro) is a natural product derivative and a protein synthesis inhibitor with cell permeability. It terminates translational elongation by incorporation into nascent peptide chains, and is widely used for nascent protein labeling and detection, enabling fluorescence imaging or affinity enrichment when combined with click chemistry.

C15AlkOPP Tetrabutylamine salt (1:2) is an FPP analogue, bearing an alkyne group to allow for post-prenylation protein labeling. C15AlkOPP Tetrabutylamine salt (1:2) can be used for Prenylomic analysis

YM 534 has antitumor activity and platelet aggregation activity, inhibits photoaffinity labeling of deglycosylated P-glycoprotein, and can be used to study leukemia.

MV151 is a fluorescent dye and a proteasome inhibitor with cell permeability, capable of specifically targeting all active subunits of proteasomes and immunoproteasomes in living cells. Used for in vitro and in vivo proteasome labeling and functional studies.

Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Biotin (Vitamin H) is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, as well as for protein and cell labeling, detection, and separation.

EDC hydrochloride (EDC-HCl Crosslinker) is a water-soluble carbodiimide compound. EDC hydrochloride, as a condensing agent, forms peptide bonds through the condensation reaction of carboxyl and amino groups and can be used to synthesize peptides with specific sequences and functions. EDC hydrochloride can covalently bind haptens to carrier proteins to form immune antigens, which are used in vaccine research. EDC hydrochloride can react with the 5 'phosphate group of nucleic acids and is used for the labeling of DNA and RNA. EDC hydrochloride can cross-link proteins with nucleic acids and is used to prepare immune cross-links. EDC hydrochloride, as a crosslinking agent, connects the amine-reactive NHS ester of biomolecules with the carboxyl group, which can be used for protein coupling to create hybrid molecules with new properties and functions.

Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1 and is widely used in biochemical experiments and drug synthesis research.

N-Hydroxysuccinimide (NHS) is a commonly employed activating ester in peptide chemistry and protein cross-linking, typically utilised to activate carboxyl groups for coupling with amine groups, serving as a key activating agent in bio-conjugate reactions.

Apixaban 13C,D3 is a deuterium labeling of Apixaban (T1736) for isotopic tracing. Apixaban 13C,D3 is a selective inhibitor of coagulation factor Xa and is used in thromboembolism studies

Edaravone (T0407), a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone-D5, retains the original compound's attributes while offering isotopic labeling benefits.

Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid-D5, is distinguished by its deuterium labeling.

FAPI-2 is a specific inhibitor of fibroblast-activated protein based on the radiotracer FAP labeling. It has anticancer activity and can be used in the study of pancreatic cancer.

Hydroxy Itraconazole D8 is a deuterated compound of itraconazole, commonly used for isotope labeling, primarily in pharmacokinetic studies, isotope-labeled analysis, and metabolic studies. Hydroxy Itraconazole is an active metabolite of itraconazole (ITZ).

Biotin Hydrazide is a carbonyl-reactive biotinylation reagent and carbonyl probe, ideal for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoproteins.

Biotin-PEG11-amine is a PEG-based linker with biotin labeling which finds application in the synthesis of PROTACs[1].

DPA-714 is a high-affinity translocator protein (TSPO) ligand (Ki=7 nM) designed with a fluorine atom, allowing labeling with fluorine-18 for in vivo imaging via positron emission tomography. [18F]DPA-714 successfully enables specific imaging of inflammation in various neuroinflammation models and a brain tumor model.

EF-5 (2-Nitroimidazole) is a agent of hypoxia labeling. It is used to identify hypoxia in cells.