stat3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28865	STAT3-IN-B9	STAT3 IN B9,B9	STAT
	STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.		STAT
T13009	STAT3-IN-1		Apoptosis , STAT
	STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.		Apoptosis , STAT
T62491	STAT3-IN-13		STAT
	STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which in...		STAT
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T13010	STAT3-IN-3		STAT
	STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.		STAT
T71550	STAT3-IN-8		STAT
	"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."		STAT
T79662	STAT3-IN-20		STAT
	STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear translocation, and subsequent gene transcription. The compound...		STAT
T73070	STAT3-IN-14
	STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .
T74545	STAT3 degrader-1
	STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].
T73035	STAT3-IN-15
	STAT3-IN-15, a potent and orally active inhibitor targeting STAT3, effectively combats idiopathic pulmonary fibrosis (IPF) by hindering STAT3 phosphorylation. Additionally, it impedes TGF-β1-induced migration and deforma...
T61779	STAT3-IN-9
	STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at...
T61030	STAT3-IN-11		Apoptosis , STAT
	STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound fo...		Apoptosis , STAT
T71351	STAT3-IN-A69
	STAT3-IN-A69 is an inhibitor targeting the DNA-binding domain of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo.
T60765	STAT3-IN-10
	STAT3-IN-10 (A11) is an inhibitor of STAT3 that directly binds to STAT3 SH2 domain, inhibits tumor cell growth and induces apoptosis in cancer cells (IC 50 = 5.18 μM) [1].
T62803	STAT3-IN-12
	STAT3-IN-12 is a potent inhibitor of STAT3 signalling and inhibits IL-6-induced activation of the JAK/STAT3 signalling pathway. STAT3-IN-12 inhibits the growth and migration of cancer cells, blocks the cell cycle and ind...
T73114	STAT3-IN-7
	STAT3-IN-7, an orally active aryl sulfonamido azetidine compound, serves as a STAT3 inhibitor with anticancer activities.
T78983	STAT3 degrader-2		STAT
	STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].		STAT
T79609	STAT3-IN-18		JAK
	STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptos...		JAK
T72754	JAK2/STAT3-IN-1
	JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T75099	PROTAC STAT3 degrader-2
	PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC 50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research [1] .