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Transferase

A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of different biochemical pathways throughout biology, and are integral to some of life's most important processes.
Cat No. product name
T10118 3-O-Methyltolcapone D7 3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a poten...
T15109 DGAT1-IN-1 DGAT1-IN-1 is a potent inhibitor of DGAT1 (IC50: < 10 nM in cell lysate from Hep3B cells overexpressing human DGAT1).
T2644 (E)-Daporinad Daporinad is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.
T17102 Tipifarnib (S enantiomer) Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
T4681 T863 T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA bi...
T14375 AZD3988 AZD3988 is an inhibitor of diacylglycerol acyl transferase-1 (DGAT-1). For human, rat, mouse, the IC50s values are 6, 5, 11 nM , respectively.
T2700 FTI-277 hydrochloride FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely rela...
T11491 GSK2973980A GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).
T1455 Nialamide Nialamide is an MAO inhibitor that is used as an antidepressive agent.
T0525 Flopropione Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
T3182 L-778123 hydrochloride The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
T6708 Tolcapone Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T24030 Entacapone acid Entacapone is a selective and reversible catechol-O-methyltransferase inhibitor.
T2678 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
T6373 Alendronate sodium hydrate Alendronate is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteo...
T3663 Eliglustat Eliglustat is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.
T4473 Ibiglustat Ibiglustat is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylc...
T7439 3-Methoxybenzamide 3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase.
T6844 GGTI298 Trifluoroacetate GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
TQ0165 Arglabin Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
T8489 Minodronic acid monohydrate Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.
TN6512 Tectol Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemi...
T38050 CP-609754 CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombin...
T6365 A 922500 A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel o...
T12426 PF-06424439 PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
T0379 Risedronic Acid Risedronic acid (Risedronate ), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
TN7057 Rosmarinate acid Rosmarinate acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively
T10119 3-O-Methyltolcapone 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for tre...
T9551 P-3FAX-Neu5Ac P-3FAX-Neu5Ac is a sialic acid analog and a sialyltransferase inhibitor.
T11599 Ibiglustat (L-Malic acid) Ibiglustat L-Malic acid (Venglustat L-Malic acid) is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with the ability to cross the blood-bra...
T11396 GGTI-2418 GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regress...
T13181 Tolcapone D7 Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
TQ0155 Miglustat hydrochloride Miglustat hydrochloride is a glucosylceramide synthase inhibitor.
T6302 Lonafarnib Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
T1599L Ibandronate sodium Ibandronate Sodium is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.
TN2437 Serotonin 5-hydroxytryptamine is a natural product from animals
T1041 Risedronate Sodium Risedronate sodium is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment...
T9186 Ervogastat Ervogastat is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcohol...
T6271 Tipifarnib Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, a...
T16398 Opicapone Opicapone reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research ...
TN3257 7beta-Methoxyrosmanol 7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
T2216 Entacapone Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).
T23109 3,5-Dinitrocatechol inhibitor of catechol-O-methyl-transferase
T2209 Serotonin hydrochloride Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=4...
T7831 Nitecapone Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)
T12425 PF-06424439 methanesulfonate PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM)[1]. PF-06424439 m...
T2765 Rosmarinic acid Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
T6937 PF-04620110 PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
3-O-Methyltolcapone D7
T10118
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a poten...
DGAT1-IN-1
T15109
DGAT1-IN-1 is a potent inhibitor of DGAT1 (IC50: < 10 nM in cell lysate from Hep3B cells overexpressing human DGAT1).
(E)-Daporinad
T2644
Daporinad is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.
Tipifarnib (S enantiomer)
T17102
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
T863
T4681
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA bi...
AZD3988
T14375
AZD3988 is an inhibitor of diacylglycerol acyl transferase-1 (DGAT-1). For human, rat, mouse, the IC50s values are 6, 5, 11 nM , respectively.
FTI-277 hydrochloride
T2700
FTI 277 hydrochloride is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely rela...
GSK2973980A
T11491
GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).
Nialamide
T1455
Nialamide is an MAO inhibitor that is used as an antidepressive agent.
Flopropione
T0525
Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
L-778123 hydrochloride
T3182
The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
Tolcapone
T6708
Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
Entacapone acid
T24030
Entacapone is a selective and reversible catechol-O-methyltransferase inhibitor.
LB42708
T2678
LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
Alendronate sodium hydrate
T6373
Alendronate is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteo...
Eliglustat
T3663
Eliglustat is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.
Ibiglustat
T4473
Ibiglustat is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylc...
3-Methoxybenzamide
T7439
3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase.
GGTI298 Trifluoroacetate
T6844
GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
Arglabin
TQ0165
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
Minodronic acid monohydrate
T8489
Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.
Tectol
TN6512
Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leuke...
CP-609754
T38050
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombin...
A 922500
T6365
A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel o...
PF-06424439
T12426
PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
Risedronic Acid
T0379
Risedronic acid (Risedronate ), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
rosmarinate acid
TN7057
Rosmarinate acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively
3-O-Methyltolcapone
T10119
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for tre...
P-3FAX-Neu5Ac
T9551
P-3FAX-Neu5Ac is a sialic acid analog and a sialyltransferase inhibitor.
Ibiglustat (L-Malic acid)
T11599
Ibiglustat L-Malic acid (Venglustat L-Malic acid) is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with the ability to cross the blood-bra...
GGTI-2418
T11396
GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regre...
Tolcapone D7
T13181
Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT.
Miglustat hydrochloride
TQ0155
Miglustat hydrochloride is a glucosylceramide synthase inhibitor.
Lonafarnib
T6302
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
Ibandronate sodium
T1599L
Ibandronate Sodium is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.
Serotonin
TN2437
5-hydroxytryptamine is a natural product from animals
Risedronate Sodium
T1041
Risedronate sodium is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment...
Ervogastat
T9186
Ervogastat is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcohol...
Tipifarnib
T6271
Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, a...
Opicapone
T16398
Opicapone reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research...
7beta-Methoxyrosmanol
TN3257
7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
Entacapone
T2216
Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).
3,5-Dinitrocatechol
T23109
inhibitor of catechol-O-methyl-transferase
Serotonin hydrochloride
T2209
Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=4...
Nitecapone
T7831
Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)
PF-06424439 methanesulfonate
T12425
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM)[1]. PF-06424439 m...
Rosmarinic acid
T2765
Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
PF-04620110
T6937
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.