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Results for "

trpchannel

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    165
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    4
    TargetMol | Peptide_Products
  • Natural Products
    35
    TargetMol | Natural_Products
  • Disease Modeling
    1
    TargetMol | Disease_Modeling_Products
Rosiglitazone
BRL49653
T0334122320-73-4
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
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Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
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D-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1 6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.
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4-6 weeks
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ap 18
T2154355224-94-7In house
AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM).
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Elismetrep
MT-8554, MT8554, MT 8554
T272531400699-64-0In house
Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.
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6-8 weeks
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N-Oleoyl Valine Ammonium salt
N-Oleoyl Valine Ammonium salt(60374-41-6 Free base)
T35921L In house
N-Oleoyl Valine Ammonium salt is an N-acyl amide compound that is a TRPV3 antagonist and can be used to study inflammation.
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Vocacapsaicin hydrochloride
CA-008 hydrochloride
T393491931116-92-5In house
Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.
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Methyl salicylate
Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-Carbomethoxyphenol
T0399119-36-8
Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.
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Probenecid
Benemid
T045757-66-9
Probenecid (Benemid) is a benzoic acid derivative with antihyperuricemic property.
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(+)-Camphor
D-Camphor, D-(+)-Camphor, (1R)-(+)-Camphor
T0882464-49-3
(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
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Nonivamide
Vanillyl-N-nonylamide, Pseudocapsaicin, Pelargonic acid vanillylamide, Nonanoic acid vanillylamide
T13212444-46-4
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and vanillylamine. It is present in chili peppers, but is commonly manufactured synthetically. It is more heat-stable than capsaicin.
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(-)-Menthol
Menthomenthol, Menthacamphor, L-Menthol, Levomenthol
T14072216-51-5
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.
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Rosiglitazone maleate
BRL 49653C, BRL 49653
T1622155141-29-0
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
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Fingolimod hydrochloride
FTY720 HCl, Fingolimod (FTY720) HCl
T2539162359-56-0
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
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Caffeic Acid
T2807331-39-5
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.
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Imperatorin
Pentosalen, Marmelosin, Ammidin, 8-Isopentenyloxypsoralene, 8-Isoamylenoxypsoralen
T2845482-44-0
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density volume and mineralization in vivo.
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Methyl syringate
Syringic Acid Methyl Ester
T3727884-35-5
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.
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trans-Cinnamaldehyde
Phenylacrolein, Cinnamic aldehyde, Cinnamaldehyde, Cinnamal
T3S155314371-10-9
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells in vitro, down-regulation of the expression and function of BCR-ABL may be one of its most important anti-leukemia mechanisms. 3. Cinnamic aldehyde and cinnamic acid are cardioprotective in a rat model of ischemic myocardial injury, the mechanism is related to anti-oxidative and anti-inflammatory properties.
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Rosiglitazone hydrochloride
Rosiglitazone HCl, BRL-49653 HCl
T6646302543-62-0
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
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Pulegone
(+)-Pulegone
TCS010289-82-7
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels. 3. Pulegone has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor.
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Amiloride hydrochloride
MK-870 hydrochloride, Amiloride HCl
T01752016-88-8
Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial.
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Pellitorine
Pellitorin, AI3-19560
T2116518836-52-7
Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
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msp3
MSP-3, MSP 3
T281181820968-63-5
MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.
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6-8 weeks
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(E)-Cardamonin
Cardamonin, Cardamomin, Alpinetin chalcone, (E)-Cardamoni
T299419309-14-9
(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the expectations toward its benefits to human health.
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