fos

Fructooligosaccharides (FOS) are naturally occurring functional oligosaccharides, which are composed of 2 to 10 fructose molecules combined with glucose molecules. They are widely found in natural plants such as bananas, onions, garlic, chicory, and honey. As a typical prebiotic, fructooligosaccharides cannot be digested and absorbed by the human body, but are selectively fermented by beneficial gut bacteria, especially bifidobacteria, to promote gut health, support microbial balance.

(RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively.

c-Fos-IN-1 (Compound P16) acts as a c-Jun inhibitor, effectively reducing the mRNA and protein levels of c-Fos. It also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. This compound demonstrates anticancer properties through the inhibition of the ERK/c-Fos/Jun pathway. c-Fos-IN-1 curbs the proliferation and migration of gastric cancer cells, with an IC50 of 2.31 μM for MGC-803 cells, causing cell cycle arrest at the G2/M phase and inducing apoptosis in cancer cells. Additionally, c-Fos-IN-1 hampers the growth of gastric cancer tumors.

Fos-Mea-8 is a useful organic compound for research related to life sciences. The catalog number is TF0020 and the CAS number is 104702-33-2.

Fos-Mea-10 is a useful organic compound for research related to life sciences. The catalog number is TF0021 and the CAS number is 557788-85-9.

Fos-Choline-10 is a useful organic compound for research related to life sciences. The catalog number is TF0022 and the CAS number is 70504-28-8.

Fos-Choline-14 is a useful organic compound for research related to life sciences. The catalog number is TF0023 and the CAS number is 77733-28-9.

Fos-Choline-ISO-11 is a useful organic compound for research related to life sciences. The catalog number is TF0024 and the CAS number is 869647-65-4.

Fos-Mea-12 is a useful organic compound for research related to life sciences. The catalog number is TF0063 and the CAS number is 129274-39-1.

Fos-Choline-8 is a useful organic compound for research related to life sciences. The catalog number is TF0064 and the CAS number is 53255-89-3.

Fos-Choline-9 is a useful organic compound for research related to life sciences. The catalog number is TF0065 and the CAS number is 253678-64-7.

Fos-Choline-11 is a useful organic compound for research related to life sciences. The catalog number is TF0066 and the CAS number is 253678-65-8.

Fos-Choline-13 is a useful organic compound for research related to life sciences. The catalog number is TF0067 and the CAS number is 85775-42-4.

Fos-Choline-Unsat-11-10 is a useful organic compound for research related to life sciences. The catalog number is TF0068 and the CAS number is 121045-77-0.

Fos-Choline-15 is a useful organic compound for research related to life sciences. The catalog number is TF0113 and the CAS number is 146801-07-2.

Fos-Choline-ISO-9 is a useful organic compound for research related to life sciences. The catalog number is TF0114 and the CAS number is 869646-90-2.

C-Fos Lentiviral CDNA ORF Clone, Human, C-GFPSpark Tag is an ORF clone of the FOS plasmid, where Fos encodes a leucine zipper protein and forms the transcription factor complex AP-1, which regulates cell proliferation, differentiation, and transformation.

Dodecylphosphocholine (DPC) is a substrate-type inhibitor of pancreas phospholipase A2. Dodecylphosphocholine is a detergent.

T-5224 is a selective inhibitor of the transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically suppresses the DNA-binding activity of c-Fos/c-Jun, thereby inhibiting IL-1β-induced transcriptional upregulation of Mmp-3, Mmp-13, and Adamts-5, without affecting the binding activity of other transcription factors. T-5224 can be used in research on rheumatoid arthritis, osteoarthritis, and cartilage degeneration.

Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.

Rabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.

Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

Fostamatinib (R788) is a small-molecule inhibitor and an oral prodrug of R406, a Syk/FLT3-targeted inhibitor (IC50 = 41 nM) that also inhibits Lyn (IC50 = 63 nM) and Lck (IC50 = 37 nM), featuring oral activity and cell permeability, used for the treatment of immune thrombocytopenia.

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long-chain fatty acid that inhibits fatty acid transport into cells. It is a potent and irreversible inhibitor of the mitochondrial respiratory chain and binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate is neuroprotective and alleviates stroke-induced neuroinflammation [1] [2].