b-9

STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.

Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models.

Dermaseptin-B9, an antimicrobial peptide, has been isolated from the Phyllomedusinae subfamily of frogs [1].

Folic acid disodium is a water-soluble and essential B-complex vitamin for the human body, playing a key role in DNA synthesis and cell division. It is used to treat anaemia and foetal neural tube defects (NTDs) caused by folate deficiency.

INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.

TB-9, a derivative of Tasiamide B, is a potent inhibitor of protease D (cathepsin D), protease E (cathepsin E), and BACE1, with IC50 values of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

(-)-(S)-B-973B is an effective allosteric agonist and positive allosteric modulator of α7 nAChR.

(S)-IB-96212 (compound 4) is an oligomycin derivative that inhibits the MurD2 reaction but does not affect the MurL reaction. This compound specifically targets and inhibits a bypass pathway of peptidoglycan biosynthesis. Additionally, (S)-IB-96212 exhibits weak inhibition of the MurD reaction.

DB-959 is a potential agonist of PPAR.

DB-959, a PPAR agonist, is used potentially for the treatment of Alzheimer's disease.

INCB-9471 HCl, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5, has potent inhibitory activity against monocyte migration and HIV-1 infection.

JB-95 acetate, a β-hairpin macrocyclic peptide, demonstrates potent antimicrobial properties by selectively compromising the outer membrane of Escherichia coli while sparing the inner membrane [1].

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1].

Leucettinib-92 (compound 92) is a kinase inhibitor selective for the DYRK/CLK families, with IC50 values of 147 nM for CLK1, 39 nM for CLK2, 5.2 nM for CLK4, 0.8 μM for CLK3, 124 nM for DYRK1A, 204 nM for DYRK1B, 0.16 μM for DYRK2, 1.0 μM for DYRK3, 0.52 μM for DYRK4, and 2.78 μM for GSK3 [1].

VIB-9600 is a human-derived antibody expressed in CHO cells, targeting FcgR2a/CD32a. It features a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 150 kDa. For its isotype control, refer to HumanIgG1kappa, Isotype Control.

IB-96212 is a macrolide that has been found in Micromonospora and has antibacterial and anticancer activities. It is active against M. luteus, B. subtilis, and S. aureus (MICs = 0.4, 100, and 100 µg/ml, respectively). IB-96212 induces death in P388, A549, HT-29, and SK-MEL-28 cells (IC50s = 0.0001, 1, 1, and 1 µg/ml, respectivel).

IB-96212 aglycone (Compound 2) represents the hydrolyzed form of IB-96212 .

JB-95 is a β-hairpin macrocyclic peptide that exhibits potent antibacterial activity against Escherichia coli. It selectively disrupts the outer membrane of E. coli without affecting the inner membrane.

Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.

ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS.

Trimebutine CTB salt (GIC-1001) is an opioid receptor agonist used in the study of pain.

Dabelotine (UNII-6RY56RB98P) is an adrenergic agonist used in the study of dementia.

Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.