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Cat No. | Product Name | Synonyms | Targets |
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T39461 | MT1 | ||
MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1). | |||
T1463 | Ramelteon | TAK-375 | Melatonin Receptor , MT Receptor |
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. | |||
T3495 | Tasimelteon | VEC-162,BMS-214778 | Melatonin Receptor , MT Receptor |
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. | |||
T1445 | Agomelatine | Thymanax,S-20098,Valdoxan | Melatonin Receptor , 5-HT Receptor |
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. | |||
T60129 | MT189 | Antiproliferative agent-14 | Microtubule Associated |
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... | |||
T11064 | DMT1 blocker 2 | Others | |
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo. | |||
T8841 | IMT1 | Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) | Others , DNA/RNA Synthesis , Mitochondrial Metabolism |
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity. | |||
T8842 | IMT1B | 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 | Others , DNA/RNA Synthesis |
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. It has anti-tumour effects. | |||
T11063 | DMT1 blocker 1 | Others | |
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo. | |||
T38421 | PRMT1-IN-1 | PRMT1-IN-1 | |
PRMT1-IN-1 is a PRMT1 inhibitor. | |||
T71739 | PTPMT1-IN-1 | ||
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor. | |||
T16834 | S26131 | N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide | MT Receptor |
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively. | |||
T9193 | ACH-000143 | Melatonin Receptor , MT Receptor | |
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. | |||
T15795 | Luzindole | N-0774 | Melatonin Receptor , MT Receptor |
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1... | |||
T10198 | 8-M-PDOT | 8-Methoxy-2-propionamidotetralin,AH-002 | MT Receptor |
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain. | |||
T1891 | NSC 405020 | MMP | |
NSC 405020 is a noncatalytic inhibitor of MT1-MMP. | |||
T10073 | 2-Iodomelatonin | Melatonin Receptor | |
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind... | |||
T28145 | ND-322 HCl | ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl | MMP |
ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion. | |||
T34081 | Piromelatine | NEU-P-11,NEU-P 11,NEU-P11 | P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel |
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... | |||
T4093 | Fabomotizole hydrochloride | Afobazole hydrochloride,CM346 hydrochloride | MAO |
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro... | |||
T60523 | Agomelatine hydrochloride | S-20098 hydrochloride | MT Receptor |
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, r... | |||
T14042 | 4-P-PDOT | 4-phenyl-2- propionamidotetralin | Melatonin Receptor , MT Receptor |
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. | |||
T22530 | 6-Chloromelatonin | Melatonin Receptor , Dopamine Receptor | |
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... | |||
T17095 | TIK-301 | PD-6735,LY-156735 | 5-HT Receptor |
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an... | |||
T80217 | BT1718 | MMP | |
BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT... | |||
T10267 | Agomelatine (L(+)-Tartaric acid) | S-20098 L(+)-Tartaric acid | 5-HT Receptor |
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonis... | |||
T70035 | Tasimelteon-d5 | ||
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... | |||
T12689 | Ramelteon metabolite M-II | Others | |
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin. | |||
T27430 | GR 196429 | GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 | |
GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR-196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice. | |||
T10266 | Agomelatine-d6 | Agomelatine D6,S-20098 D6 | Others |
Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors. | |||
T10193 | 7-Desmethyl-agomelatine | Others | |
7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. | |||
T10192 | 7-Desmethyl-3-hydroxyagomelatine | 3-Hydroxy-7-desmethyl agomelatine | 5-HT Receptor |
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist. | |||
T70073 | Fabomotizole dihydrochloride | ||
Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant action... | |||
T71963 | (−)-WIN 55,212-3 mesylate | ||
(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ... | |||
T78436 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | MMP | |
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for the real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1)... | |||
T60490 | Melatonin receptor agonist 1 | ||
Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1]. | |||
T28645 | S-22153 | ||
S22153 is an antagonist of melatonin receptor. |
Cat No. | Product Name | Synonyms | Targets |
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T2O2728 | Glycine | 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll | MT Receptor , Endogenous Metabolite , iGluR |
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. |
Cat No. | Product Name | Species | Expression System |
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TMPY-04477 | CKMT1A Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes that encodes the ubiquitous mitoch... | |||
TMPY-02602 | PTPMT1 Protein, Human, Recombinant (His) | Human | E. coli |
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates pho... | |||
TMPH-01712 | TRMT112 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
TMPH-01667 | MT1X Protein, Human, Recombinant (GST) | Human | E. coli |
Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-s... | |||
TMPJ-00484 | SHMT1 Protein, Human, Recombinant (His) | Human | Human Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to g... | |||
TMPH-02564 | CARNMT1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded protei... | |||
TMPH-01666 | MT1G Protein, Human, Recombinant (GST) | Human | E. coli |
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. | |||
TMPY-05717 | Integrin alpha V beta 8 Protein, Human, Recombinant (His) | Human | HEK293 |
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cyto... | |||
TMPY-01477 | MMP-2 Protein, Human, Recombinant | Human | HEK293 |
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de... | |||
TMPY-00610 | RAB2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and i... | |||
TMPY-02290 | MMP-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de... |