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Search Results for " mt1 "

37

Compounds

1

Natural Products

11

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T39461 MT1
MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1).
T1463 Ramelteon TAK-375 Melatonin Receptor , MT Receptor
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T3495 Tasimelteon VEC-162,BMS-214778 Melatonin Receptor , MT Receptor
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T1445 Agomelatine Thymanax,S-20098,Valdoxan Melatonin Receptor , 5-HT Receptor
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T60129 MT189 Antiproliferative agent-14 Microtubule Associated
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...
T11064 DMT1 blocker 2 Others
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
T8841 IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) Others , DNA/RNA Synthesis , Mitochondrial Metabolism
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
T8842 IMT1B 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 Others , DNA/RNA Synthesis
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. It has anti-tumour effects.
T11063 DMT1 blocker 1 Others
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo.
T38421 PRMT1-IN-1 PRMT1-IN-1
PRMT1-IN-1 is a PRMT1 inhibitor.
T71739 PTPMT1-IN-1
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
T16834 S26131 N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide MT Receptor
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively.
T9193 ACH-000143 Melatonin Receptor , MT Receptor
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T10198 8-M-PDOT 8-Methoxy-2-propionamidotetralin,AH-002 MT Receptor
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain.
T1891 NSC 405020 MMP
NSC 405020 is a noncatalytic inhibitor of MT1-MMP.
T10073 2-Iodomelatonin Melatonin Receptor
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind...
T28145 ND-322 HCl ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl MMP
ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.
T34081 Piromelatine NEU-P-11,NEU-P 11,NEU-P11 P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T4093 Fabomotizole hydrochloride Afobazole hydrochloride,CM346 hydrochloride MAO
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro...
T60523 Agomelatine hydrochloride S-20098 hydrochloride MT Receptor
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, r...
T14042 4-P-PDOT 4-phenyl-2- propionamidotetralin Melatonin Receptor , MT Receptor
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T22530 6-Chloromelatonin Melatonin Receptor , Dopamine Receptor
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...
T17095 TIK-301 PD-6735,LY-156735 5-HT Receptor
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an...
T80217 BT1718 MMP
BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT...
T10267 Agomelatine (L(+)-Tartaric acid) S-20098 L(+)-Tartaric acid 5-HT Receptor
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonis...
T70035 Tasimelteon-d5
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ...
T12689 Ramelteon metabolite M-II Others
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin.
T27430 GR 196429 GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR-196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice.
T10266 Agomelatine-d6 Agomelatine D6,S-20098 D6 Others
Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors.
T10193 7-Desmethyl-agomelatine Others
7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T10192 7-Desmethyl-3-hydroxyagomelatine 3-Hydroxy-7-desmethyl agomelatine 5-HT Receptor
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T70073 Fabomotizole dihydrochloride
Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant action...
T71963 (−)-WIN 55,212-3 mesylate
(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ...
T78436 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 MMP
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for the real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1)...
T60490 Melatonin receptor agonist 1
Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1].
T28645 S-22153
S22153 is an antagonist of melatonin receptor.

Compounds

MT1
T39461
Synonym:
Target:
Ramelteon
T1463
Synonym: TAK-375
Target: Melatonin Receptor, MT Receptor
Tasimelteon
T3495
Synonym: VEC-162,BMS-214778
Target: Melatonin Receptor, MT Receptor
Agomelatine
T1445
Synonym: Thymanax,S-20098,Valdoxan
Target: Melatonin Receptor, 5-HT Receptor
MT189
T60129
Synonym: Antiproliferative agent-14
Target: Microtubule Associated
DMT1 blocker 2
T11064
Synonym:
Target: Others
IMT1
T8841
Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)
Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism
IMT1B
T8842
Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974
Target: Others, DNA/RNA Synthesis
DMT1 blocker 1
T11063
Synonym:
Target: Others
PRMT1-IN-1
T38421
Synonym: PRMT1-IN-1
Target:
PTPMT1-IN-1
T71739
Synonym:
Target:
S26131
T16834
Synonym: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide
Target: MT Receptor
ACH-000143
T9193
Synonym:
Target: Melatonin Receptor, MT Receptor
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
8-M-PDOT
T10198
Synonym: 8-Methoxy-2-propionamidotetralin,AH-002
Target: MT Receptor
NSC 405020
T1891
Synonym:
Target: MMP
2-Iodomelatonin
T10073
Synonym:
Target: Melatonin Receptor
ND-322 HCl
T28145
Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl
Target: MMP
Piromelatine
T34081
Synonym: NEU-P-11,NEU-P 11,NEU-P11
Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel
Fabomotizole hydrochloride
T4093
Synonym: Afobazole hydrochloride,CM346 hydrochloride
Target: MAO
Agomelatine hydrochloride
T60523
Synonym: S-20098 hydrochloride
Target: MT Receptor
4-P-PDOT
T14042
Synonym: 4-phenyl-2- propionamidotetralin
Target: Melatonin Receptor, MT Receptor
6-Chloromelatonin
T22530
Synonym:
Target: Melatonin Receptor, Dopamine Receptor
TIK-301
T17095
Synonym: PD-6735,LY-156735
Target: 5-HT Receptor
BT1718
T80217
Synonym:
Target: MMP
Agomelatine (L(+)-Tartaric acid)
T10267
Synonym: S-20098 L(+)-Tartaric acid
Target: 5-HT Receptor
Tasimelteon-d5
T70035
Synonym:
Target:
Ramelteon metabolite M-II
T12689
Synonym:
Target: Others
GR 196429
T27430
Synonym: GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
Target:
Agomelatine-d6
T10266
Synonym: Agomelatine D6,S-20098 D6
Target: Others
7-Desmethyl-agomelatine
T10193
Synonym:
Target: Others
7-Desmethyl-3-hydroxyagomelatine
T10192
Synonym: 3-Hydroxy-7-desmethyl agomelatine
Target: 5-HT Receptor
Fabomotizole dihydrochloride
T70073
Synonym:
Target:
(−)-WIN 55,212-3 mesylate
T71963
Synonym:
Target:
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
T78436
Synonym:
Target: MMP
Melatonin receptor agonist 1
T60490
Synonym:
Target:
S-22153
T28645
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2O2728 Glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll MT Receptor , Endogenous Metabolite , iGluR
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04477 CKMT1A Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes that encodes the ubiquitous mitoch...
TMPY-02602 PTPMT1 Protein, Human, Recombinant (His) Human E. coli
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates pho...
TMPH-01712 TRMT112 Protein, Human, Recombinant (His & SUMO) Human E. coli
TMPH-01667 MT1X Protein, Human, Recombinant (GST) Human E. coli
Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-s...
TMPJ-00484 SHMT1 Protein, Human, Recombinant (His) Human Human Cells
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to g...
TMPH-02564 CARNMT1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded protei...
TMPH-01666 MT1G Protein, Human, Recombinant (GST) Human E. coli
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
TMPY-05717 Integrin alpha V beta 8 Protein, Human, Recombinant (His) Human HEK293
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cyto...
TMPY-01477 MMP-2 Protein, Human, Recombinant Human HEK293
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de...
TMPY-00610 RAB2 Protein, Mouse, Recombinant (His) Mouse E. coli
RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and i...
TMPY-02290 MMP-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de...
TargetMol