pet

cGMP-dependent protein kinase (PKG) inhibitor

PET-16 is a HSP70 inhibitor.

DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells.

DOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection.

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.

CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.7 nM). It is synthesized via Cu-mediated 18F-fluorination and demonstrates significant brain uptake in a mouse model of neuroinflammation [1].

Sp-8-pCPT-PET-cGMPS acts as an activator of PKG-I. It is utilized in studying the role of the NO/NOS/sGC/PKG-I signaling pathway in cardiac differentiation.

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG activator and an inhibitor of the membrane-permeable retinal cGMP-gated ion channels (cGMP-gated ion channel). It also serves as an activator for cGMP-dependent protein kinase I α and β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, Sp-8-Br-PET-cGMPS does not undergo metabolic side effects and exhibits stronger lipophilicity and permeability compared to Sp-8-pCPT-cGMPS. This compound is useful for investigating the role of the cGMP signaling pathway in the nervous system.

8-Br-PET-cGMP is an agonist of type I cyclic GMP-dependent protein kinase (cGKI), which promotes the dimerization and activation of the catalytic activity of cGKI by binding to its regulatory domain. This compound is utilized to investigate the role of the cGMP signaling pathway in cell growth, vasodilation, and smooth muscle cell functions.

Petesicatib (RG 7625) is a small molecule histone-S (Cat-S) inhibitor for the study of primary dry syndrome and autoimmune diseases.

Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.

Epetirimod (S-30563) is a small molecule immunomodulator with antitumor and anti-infective activity for the study of papillomavirus infections.

Wampetin is a useful organic compound for research related to life sciences. The catalog number is T124020 and the CAS number is 87838-97-9.

Gossypetin 3-methylether is a useful organic compound for research related to life sciences and the catalog number is T124054.

PETCM is a caspase-3 activator and acts as an cytochrome c (cyto c)-dependent manner.

Petasinoside is a useful organic compound for research related to life sciences and the catalog number is T124362.

Petasinine is a useful organic compound for research related to life sciences and the catalog number is T124363.

Neopetasitenine is a useful organic compound for research related to life sciences and the catalog number is T124565.

Petasitenine is a useful organic compound for research related to life sciences and the catalog number is T124576.

Isopetasol is a useful organic compound for research related to life sciences. The catalog number is T124819 and the CAS number is 469-67-0.

6-Dehydropetasol is a useful organic compound for research related to life sciences. The catalog number is T126078 and the CAS number is 129704-82-1.

Petiolin G is a useful organic compound for research related to life sciences and the catalog number is T126232.

Nepetaside is a useful organic compound for research related to life sciences. The catalog number is T126348 and the CAS number is 114076-56-1.