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Search Results for " th1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T3100 GSK-J4 GSK J4 HCl Apoptosis , Histone Demethylase
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit...
T19675 SM360320 CL-087,SM 360320,CL 087,1V136,SM-360320,CL087 TLR
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...
T4383 GSK-J4 Hydrochloride GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) Histone Demethylase
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
T67864 TH1760 MKB NUDIX hydrolase
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia ef...
T8727 TH1020 TLR , Antibacterial
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T60034 TH1085 Others
TH1085 is an enhancer of OGG1. TH1085 stimulates DNA repair and protects cells from the environmental hazard paraquat (PQ).
T38271 TH1217 TH 1217 Others
TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential again...
T12122 MTH1-IN-2 MTH1
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
T37313 ITH15004
ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor whe...
T78681 ITH12711 Phosphatase
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
T17068 TH1834 dihydrochloride Others
TH1834 dihydrochloride is a specific Tip60 histone acetyltransferase inhibitor. TH1834 dihydrochloride causes apoptosis and enhances DNA damage in breast cancer.
T39554 TH1834 TH1834
TH1834 is a selective inhibitor of the Tip60 (KAT5) histone acetyltransferase (HAT). It effectively induces apoptosis and promotes DNA damage in breast cancer cells. Notably, TH1834 does not influence the activity of the...
T28959 TH1338 TH-1318,TH 1318,TH1318
TH-1318 is a brain penetrable antitumor agent.
T16425 PA452 Retinoid Receptor , RAR/RXR 
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
T34295 Resiniferatoxin RTX,[3H]resiniferatoxin IL Receptor
Resiniferatoxin ([3H]resiniferatoxin) inhibits the production of Th1 cytokines, contributing to the defense against T. spiralis infection, and can be used in studies about the modulator of the immune response.
TN2088 Platycodin D2 IL Receptor , HBV
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci...
T21618L Myelin Basic Protein (87-99) Acetate Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base) Others
Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein (87-99) Ac...
T76884 Spesolimab BI 655130 IL Receptor
Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p...
T4A2462 Telocinobufagin Telobufotoxin,Telocinobufogenin Others
1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall...
T5681 ETHYL CAFFEATE ETHYL 3,4-DIHYDROXYCINNAMATE NF-κB , COX , PGE Synthase , NO Synthase
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...
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