cxcr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10905	CXCR2-IN-1		CXCR
	CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.		CXCR
T7681	AZD-5069		CXCR
	AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).		CXCR
T1955	SB225002		CXCR
	SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.		CXCR
T3047	SRT3109		CXCR
	SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.		CXCR
T39078	CXCR7 antagonist-1	CXCR7 antagonist-1	CXCR
	CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7. CXCR7 antagonist-1 prevents tumor cell proliferation and tumor formation and can be used in stud...		CXCR
T4163	Reparixin	DF 1681Y,Repertaxin	CXCR
	Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).		CXCR
T1739	WZ811		CXCR
	WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).		CXCR
T3992	MSX-122	MSX 122,MSX122	CXCR
	MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).		CXCR
T5193	Danirixin	GSK1325756	CXCR
	Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).		CXCR
T17208	USL311		CXCR
	USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing...		CXCR
T2477	UNBS5162	UNBS 5162,UNBS-5162	CXCR , Autophagy
	UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.		CXCR , Autophagy
T4033	MSX-130	MSX 130	CXCR
	MSX-130 is CXCR4 Antagonist.		CXCR
T9721	ML339		CXCR
	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.		CXCR
T4032	MSX-127	MSX 127	CXCR
	MSX-127 elicites positive response in peptide CXCR4.		CXCR
TQ0174	Mavorixafor	AMD-070	CXCR
	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC...		CXCR
T10297L	AMG 487		CXCR
	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.		CXCR
T8497	SX-682		CXCR
	SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.		CXCR
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T3396	Baohuoside I	Icariside-II,Icariin-II	Apoptosis , CXCR
	Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.		Apoptosis , CXCR
T7499	TAK-779	Takeda 779	HIV Protease , CXCR , CCR
	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).		HIV Protease , CXCR , CCR