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Search Result

Search Results for " cxcr "

Targets

CXCR CXCR

59

Compounds

3

Natural Products

5

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T10905 CXCR2-IN-1 CXCR
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T7681 AZD-5069 CXCR
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
T1955 SB225002 CXCR
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
T3047 SRT3109 CXCR
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T4163 Reparixin DF 1681Y,Repertaxin CXCR
Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).
T39078 CXCR7 antagonist-1 CXCR7 antagonist-1 CXCR
CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7. CXCR7 antagonist-1 prevents tumor cell proliferation and tumor formation and can be used in stud...
T1739 WZ811 CXCR
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
T3992 MSX-122 MSX 122,MSX122 CXCR
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
T5193 Danirixin GSK1325756 CXCR
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
T17208 USL311 CXCR
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing...
T2477 UNBS5162 UNBS 5162,UNBS-5162 CXCR , Autophagy
UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
T4033 MSX-130 MSX 130 CXCR
MSX-130 is CXCR4 Antagonist.
T9721 ML339 CXCR
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
T4032 MSX-127 MSX 127 CXCR
MSX-127 elicites positive response in peptide CXCR4.
TQ0174 Mavorixafor AMD-070 CXCR
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC...
T10297L AMG 487 CXCR
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
T8497 SX-682 CXCR
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
T16850 SB-265610 GSK-CXCR2 CXCR
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...
T7499 TAK-779 Takeda 779 HIV Protease , CXCR , CCR
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T11179 Elubrixin SB-656933 IL Receptor , CXCR
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...
T7130 Navarixin MK-7123,SCH 527123 CXCR
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef...
T39742 CXCR4 antagonist 2
CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.
T12705 Reparixin L-lysine salt Repertaxin L-lysine salt CXCR
Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T13324 VUF11207 fumarate CXCR , Arrestin
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
T10906 CXCR7 modulator 1 Others
CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.
T36982 CXCR3 Antagonist 6c
CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC...
T7208 AMD 3465 hexahydrobromide GENZ-644494 (hexahydrobromide) HIV Protease , CXCR
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
T33763 NVP CXCR2 20 NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220
NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability.
T10907 CXCR7 modulator 2 Others
CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.
T40786 CXCR4 antagonist 1 CXCR4 antagonist 1
CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.
T36923 CXCR2-IN-2 CXCR2-IN-2
CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the β-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-f...
T6764 ATI-2341 ATI2341 CXCR
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobil...
T36443 (R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2
(R,R)-CXCR2-IN-2, a diastereoisomer of CXCR2-IN-2 (compound 68), functions as a brain-penetrant CXCR2 antagonist. It exhibits a pIC50 of 9 in the Tango assay and 6.8 in the HWB Gro-α induced CD11b expression assay[1].
T1776 Plerixafor JM3100,AMD 3100,AMD-3329 Virus Protease , HIV Protease , CXCR
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
T1776L Plerixafor octahydrochloride JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl Virus Protease , HIV Protease , CXCR
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a...
T61409 CXCR4 antagonist 3
CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stabili...
T61386 CXCR2 antagonist 2
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.
T79059 CXCR4-IN-1 CXCR
CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic retinopathy, and inflammation [1].
T61447 CXCR2 antagonist 4
CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. ...
T61359 CXCR2 antagonist 6
CXCR2 antagonist 6 (compound 35c) is a potent CXCR2 antagonist. CXCR2 antagonist 6 shows potent CXCR2 binding affinity ( IC 50 =0.044 μM) and calcium mobilization ( IC 50 =0.66 μM) [ 1].
T61235 CXCR2 antagonist 5
CXCR2 antagonist 5 (compound 25) is a potent CXCR2 antagonist. CXCR2 antagonist 5 shows potent CXCR2 binding affinity ( IC 50 =0.013 μM) and calcium mobilization ( IC 50 =0.1 μM) [ 1].
T61419 CXCR4 antagonist 5
CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 ...
T61650 CXCR4 antagonist 9
CXCR4 antagonist 9 (Compound 2) is a potent CXCR4 antagonist displaying an IC50 of 15 nM. It effectively inhibits the cytosolic calcium increase induced by CXCL12, with an IC50 value of 1.3 nM [1].
T62325 CXCR7 antagonist-1 hydrochloride
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of SDF-1 chemokine (also known as CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. hydrochloride can be u...
T61420 CXCR4 antagonist 6
CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 anta...
T62007 CXCR4 modulator-1
CXCR4 modulator-1 (compound ZINC72372983) is a potent CXCR4 modulator (EC 50= 100 nM). CXCR4 modulator-1 has research value in anti-inflammatory, anticancer and anti-HIV.
T60696 CXCR2 antagonist 8
CXCR2 antagonist 8 is a potent and selective antagonist of CXCR2 that can be used for the researching of insulin resistance [1].
T64306 CXCR4 probe 1
CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer that acts on the CXCR4-specific antagonist TN14003 (IC50: 6.9 nM). The CXCR4 probe 1 has potential as a CXCR4-specific imaging probe for the d...
T61236 CXCR2 antagonist 7
CXCR2 antagonist 7 (compound 19) is a potent CXCR2 antagonist. CXCR2 antagonist 7 shows potent CXCR2 binding affinity ( IC 50 =0.044 μM) and calcium mobilization ( IC 50 =0.66 μM) [ 1].
T80216 DOTA-CXCR4-L CXCR
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer [1].

Compounds

CXCR2-IN-1
T10905
Synonym:
Target: CXCR
AZD-5069
T7681
Synonym:
Target: CXCR
SB225002
T1955
Synonym:
Target: CXCR
SRT3109
T3047
Synonym:
Target: CXCR
Reparixin
T4163
Synonym: DF 1681Y,Repertaxin
Target: CXCR
CXCR7 antagonist-1
T39078
Synonym: CXCR7 antagonist-1
Target: CXCR
WZ811
T1739
Synonym:
Target: CXCR
MSX-122
T3992
Synonym: MSX 122,MSX122
Target: CXCR
Danirixin
T5193
Synonym: GSK1325756
Target: CXCR
USL311
T17208
Synonym:
Target: CXCR
UNBS5162
T2477
Synonym: UNBS 5162,UNBS-5162
Target: CXCR, Autophagy
MSX-130
T4033
Synonym: MSX 130
Target: CXCR
ML339
T9721
Synonym:
Target: CXCR
MSX-127
T4032
Synonym: MSX 127
Target: CXCR
Mavorixafor
TQ0174
Synonym: AMD-070
Target: CXCR
AMG 487
T10297L
Synonym:
Target: CXCR
SX-682
T8497
Synonym:
Target: CXCR
SB-265610
T16850
Synonym: GSK-CXCR2
Target: CXCR
TAK-779
T7499
Synonym: Takeda 779
Target: HIV Protease, CXCR, CCR
Elubrixin
T11179
Synonym: SB-656933
Target: IL Receptor, CXCR
Navarixin
T7130
Synonym: MK-7123,SCH 527123
Target: CXCR
CXCR4 antagonist 2
T39742
Synonym:
Target:
Reparixin L-lysine salt
T12705
Synonym: Repertaxin L-lysine salt
Target: CXCR
VUF11207 fumarate
T13324
Synonym:
Target: CXCR, Arrestin
CXCR7 modulator 1
T10906
Synonym:
Target: Others
CXCR3 Antagonist 6c
T36982
Synonym:
Target:
AMD 3465 hexahydrobromide
T7208
Synonym: GENZ-644494 (hexahydrobromide)
Target: HIV Protease, CXCR
NVP CXCR2 20
T33763
Synonym: NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220
Target:
CXCR7 modulator 2
T10907
Synonym:
Target: Others
CXCR4 antagonist 1
T40786
Synonym: CXCR4 antagonist 1
Target:
CXCR2-IN-2
T36923
Synonym: CXCR2-IN-2
Target:
ATI-2341
T6764
Synonym: ATI2341
Target: CXCR
(R,R)-CXCR2-IN-2
T36443
Synonym: (R,R)-CXCR2-IN-2
Target:
Plerixafor
T1776
Synonym: JM3100,AMD 3100,AMD-3329
Target: Virus Protease, HIV Protease, CXCR
Plerixafor octahydrochloride
T1776L
Synonym: JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl
Target: Virus Protease, HIV Protease, CXCR
CXCR4 antagonist 3
T61409
Synonym:
Target:
CXCR2 antagonist 2
T61386
Synonym:
Target:
CXCR4-IN-1
T79059
Synonym:
Target: CXCR
CXCR2 antagonist 4
T61447
Synonym:
Target:
CXCR2 antagonist 6
T61359
Synonym:
Target:
CXCR2 antagonist 5
T61235
Synonym:
Target:
CXCR4 antagonist 5
T61419
Synonym:
Target:
CXCR4 antagonist 9
T61650
Synonym:
Target:
CXCR7 antagonist-1 hydrochloride
T62325
Synonym:
Target:
CXCR4 antagonist 6
T61420
Synonym:
Target:
CXCR4 modulator-1
T62007
Synonym:
Target:
CXCR2 antagonist 8
T60696
Synonym:
Target:
CXCR4 probe 1
T64306
Synonym:
Target:
CXCR2 antagonist 7
T61236
Synonym:
Target:
DOTA-CXCR4-L
T80216
Synonym:
Target: CXCR
1 2
Cat No. Product Name Synonyms Targets
T3396 Baohuoside I Icariside-II,Icariin-II Apoptosis , CXCR
Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
T3S1416 Decursin Decursinol angelate,(+)-Decursin Apoptosis , PKC
1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...
T0617 Nicotinamide N-oxide Nicotinamide-N-oxide,Nicotinamide 1-oxide,1-oxynicotinamide c-Myc , Endogenous Metabolite , CXCR , Drug Metabolite
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of n...

Natural Products

Baohuoside I
T3396
Synonym: Icariside-II,Icariin-II
Target: Apoptosis, CXCR
Decursin
T3S1416
Synonym: Decursinol angelate,(+)-Decursin
Target: Apoptosis, PKC
Nicotinamide N-oxide
T0617
Synonym: Nicotinamide-N-oxide,Nicotinamide 1-oxide,1-oxynicotinamide
Target: c-Myc, Endogenous Metabolite, CXCR, Drug Metabolite

Recombinant Proteins

Species：
Human (4)
Mouse (1)
Expression System：
E. coli (3)
HEK293 (1)
Human Cells (1)
Tag：
N-Fc (1)
N-terminal 6xHis-GST-tagged (1)
N-terminal 6xHis-KSI-tagged (1)
None (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPH-01162 CXCR3 Protein, Human, Recombinant (GST & His) Human E. coli
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPH-02612 CXCR3 Protein, Mouse, Recombinant (His & KSI) Mouse E. coli
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell c...
TMPJ-01037 CXCR4 Protein, Human, Recombinant (hFc) Human Human Cells
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor ...
TMPY-06553 CXCR4 Protein, Human, Recombinant Human HEK293
CXCR4 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 39.75 kDa. Accession number: P61073-1
TMPJ-00760 CXCL7 Protein, Human, Recombinant Human E. coli
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domai...
Cat No. Product Name
L7600 Chemokine Inhibitor Library

59 compounds
A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;

Libraries

Chemokine Inhibitor Library
L7600
Compounds: 59
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