β2ar

β2AR M-receptor agonist-2 is a dual-function compound acting as a muscarinic antagonist and β2 adrenoceptor agonist (MABA). It demonstrates significant activity towards the β2 adrenoceptor with an EC50 of 3.7 nM and exhibits affinity for the human cloned M3 receptor with a Ki of 0.73 nM. This potent bronchodilator holds potential for research in chronic obstructive pulmonary disease (COPD) treatment.

β2AR antagonist 1 (Cmpd-15PA) acts as an antagonist to the β2 adrenergic receptor (β2AR). This compound binds to the intracellular surface of β2AR.

Compound 9a (β2AR agonist 3) is a β2-adrenergic receptor (β2AR) agonist used in type 2 diabetes research [1].

β2AR M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and muscarinic receptor, with an EC50 value of 9.2 nM for β2 adrenoceptor and a Ki value of 30.2 nM for the muscarinic receptor, and an EC50 value of 4.0 nM highlighting its MABA activity [1].

PF-4348235 HCl (β2AR M-receptor agonist-2 HCl) is a muscarinic M3 receptor antagonist (Ki: 0.73 nM) and β2 adrenergic receptor agonist (MABA, EC50: 3.7 nM). PF-4348235 HCl is also a bronchial BM213 acetate is a bronchodilator used to study cardiovascular and respiratory diseases such as chronic obstructive pulmonary disease (COPD).

Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

PF-4348235 2HCl is an adrenergic agonist and muscarinic receptor antagonist, a bronchodilator, and may be used in the study of chronic obstructive pulmonary disease.

DFPQ is a powerful and selective β-arrestin-biased negative allosteric modulator(NAM) targeting the β2-adrenergic receptor. It specifically inhibits the interaction of β-arrestin with β2AR without altering β-agonist-induced cAMP production. Additionally, DFPQ reduces functional desensitization of the β2AR in airway smooth muscle, enhancing β-agonists' capacity to maintain bronchorelaxation and curbing cell migration during prolonged β-agonist treatment.

CACPD2011a-0001278239 is a β2AR hybrid agonist with high affinity binding to both the wild-type and T164I β2AR variants. It exhibits neither cytotoxicity nor mutagenicity, making it suitable for asthma research.

BI-167107 is a high-affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a Kd of 84 pM.

Rac-Propranolol-d7 is a 2H-labeled Rac-Propranolol. Propranolol is an effective β-adrenergic receptor (βAR) antagonist that inhibits β1AR and β2AR, used in cardiovascular and metabolic disease research.

Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity.

Phenyl-ac-Gly-OH is an endogenous metabolite that activates β2AR and can be used in the study of ischemia reperfusion-induced cardiac injury.

NSC305787 is an ezrin inhibitor with antitumor activity, inhibits PKCΙ-induced ezrin phosphorylation, reduces β2AR expression in the cell membrane, and induces intracellular vesicular or punctate expression of ezrin and β2AR, and can be used to study pancreatic cancer.

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).

Todralazine hydrochloride (Ecarazine hydrochloride) is a β2AR blocker with antioxidant and free radical scavenging properties, making it suitable for anti-hypertensive research.

Phenyl-ac-Gly-OH is an endogenous metabolite that activates β2AR and can be used in the study of ischemia reperfusion-induced cardiac injury.

Metaproterenol hemisulfate (Orciprenaline sulfate) is a beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.