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Results for "

Wnt–β-catenin

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    217
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Wnt/β-catenin agonist 1
T133442305372-67-0
Wnt β-catenin agonist 1 is an agonist of Wnt β-catenin signalling pathway(EC50 of 0.27 μM).
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6-8 weeks
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Wnt/β-catenin-IN-5
T201077
Wnt β-catenin-IN-5 (Compound 4) functions as an inhibitor of the Wnt β-catenin signaling pathway. This compound effectively eradicates colorectal cancer stem cells and inhibits tumor growth by suppressing the Wnt signaling pathway. Additionally, Wnt β-catenin-IN-5 promotes the degradation of KDM3A and KDM3B.
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Wnt/β-catenin activator 1
T205586
Wnt β-catenin activator 1 (Compound 5m) is an orally active activator of the Wnt β-catenin signaling pathway. It induces cell cycle arrest in the G1 phase, inhibits early proliferation of adipocytes, and suppresses adipogenesis in 3T3-L1 cells with an IC50 of 330 nM. In a high-fat diet-fed Syrian golden hamster model, Wnt β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities.
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Wnt/β-catenin agonist 2
T41094943820-93-7
Wnt β-catenin agonist 2 activates Wnt β-catenin signaling and is an effective Wnt agonist. Wnt β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer invasion and metastasis.
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Wnt/β-catenin agonist 4
T60803912784-79-3
Wnt β-catenin agonist 4 is an agonist of Wnt that activates Wnt β-catenin signaling and directs signaling.
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6-8 weeks
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hCA/Wnt/β-catenin-IN-1
T82235
hCA Wnt β-catenin-IN-1 (Compd 15) is an inhibitor selectively targeting hCA isoforms II, IX, and XII, with K i values of 33.6, 24.1, and 6.8 nM, respectively. It also attenuates P-gp activity, disrupts the Wnt β-catenin signaling pathway, and compromises the viability of cancer cells, specifically against the NCI ADR-RES DOX-resistant cell line [1].
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Wnt/β-catenin-IN-2
T876321397006-01-7
Wnt β-catenin-IN-2 (Compound 3235-0367) serves as an inhibitor of the Wnt β-catenin signaling pathway, exhibiting IC50 and KD values of 7.1 and 2.5 μM, respectively. It is applicable in cancer research [1].
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10-14 weeks
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Wnt/β-catenin-IN-3
T876331809413-98-6
Wnt β-catenin-IN-3 (compound 17), a Wnt β-catenin inhibitor, exhibits low micromolar GI 50 s across different cancer cell lines. It induces G2 M cell cycle arrest through the activation of the p53-p21 pathway and promotes both intrinsic and extrinsic apoptotic death in colon cancer cells [1].
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10-14 weeks
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Wnt/β-catenin agonist 3
T9988912790-59-1
Wnt β-catenin agonist 3 is a Wnt beta-catenin agonist.
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CHIR-99021
Laduviglusib, CT99021, CHIR-99021
T2310252917-06-9
CHIR-99021 (CT99021) is an activator of the Wnt β-catenin signaling pathway and a GSK-3α β inhibitor (IC50=10 6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in mouse and human embryonic stem cells.
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TargetMol | Inhibitor Hot
iwp-2
IWP2
T2702686770-61-6
IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1δ inhibitor (IC50=40 nM for M82FCK1δ). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research.
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TargetMol | Inhibitor Hot
BML-284
Wnt agonist 1
T3144853220-52-7
BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
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TargetMol | Inhibitor Hot
Adavivint
Adavivint (SM04690)
T56361467093-03-3
Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF LEF reporter gene experiments.
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TargetMol | Inhibitor Hot
ICG-001
T6113780757-88-2
ICG001 is a β-catenin TCF-mediated transcription inhibitor that selectively blocks β-catenin CBP interaction without interfering with β-catenin p300 interaction. It specifically binds to CREB protein with an IC50 of 3 μM.
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4-6 weeks
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TargetMol | Inhibitor Hot
SKL2001
T6989909089-13-0
SKL2001, an agonist of the Wnt β-catenin pathway, can disrupt the Axin β-catenin interaction.
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TargetMol | Inhibitor Hot
MSAB
T8710173436-66-3
MSAB is a selective inhibitor of Wnt β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt β-catenin target genes.
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TargetMol | Inhibitor Hot
HLY78
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
T11571854847-61-3In house
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
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Wnt pathway activator 2
T133451360540-82-4In house
Wnt pathway activator 2, with an IC50 of 13 nM, is a potent Wnt activator.
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6-8 weeks
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DK419
T151372102672-22-8In house
DK419 is an orally active inhibitor of Wnt β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
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6-8 weeks
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CCT 031374 hydrobromide
T216851219184-91-4In house
CCT 031374 hydrobromide is a TCF β-catenin inhibitor with antitumor activities.
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FzM1
FzM 1, FzM-1
T240761680196-54-6In house
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT β-catenin signaling pathway.
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6-8 weeks
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Gossypolone
T319874547-72-2In house
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch Wnt signaling and induces apoptosis.
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8-10weeks
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GSK-3β inhibitor 8
GSK3β Inhibitor XVIII
T355561139875-74-3In house
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation.
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8-10 weeks
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Carboxylesterase-IN-3
T607882764748-92-5In house
Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
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10-14 weeks
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TargetMol | Inhibitor Sale