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Search Result

Search Results for " sk2 "

20

Compounds

Cat No. Product Name Synonyms Targets
T12256 NS8593 hydrochloride NS8593 HCl Potassium Channel
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
T3518 GSK269962A GSK269962B,GSK 269962,GSK269962A HCl ROCK , S6 Kinase
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T31207 GSK233705 Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B AChR
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans.
T2436 GSK2801 Apoptosis , Epigenetic Reader Domain
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T4418 GSK2879552 2HCl (1401966-69-5(free base)) Histone Demethylase
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
T6850L GSK2292767 FA GSK2292767 FA(1254036-66-2 Free base) PI3K
GSK2292767 FA is a potent and selective inhibitor of PI3Kδ (pIC50 : 10.1).GSK2292767 FA is more than 500-fold more selective than other PI3K isoforms.GSK2292767 FA can be used in the study of respiratory diseases.
T11485 GSK2643943A DUB
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
T15436 GSK2838232 HIV Protease
GSK2838232 inhibit HIV reverse transcriptase activity across a broad panel of HIV-1 isolates,GSK2838232 is novel human immune virus (HIV) maturation inhibitor.
T15432 GSK256073 GPR , Others
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inh...
T4531 GSK2200150A Antibacterial
GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.
T6054 GSK256066 PDE
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.
T27454 GSK2008607 Raf
GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
T2073 GSK2636771 GSK 2636771,GSK-2636771 PI3K
GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.
T11488 GSK2850163 IRE1
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
T9830 GSK2556286 GSK286 Antibacterial
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul...
T7151 GSK2982772 RIP kinase
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T2348 GSK2334470 PDK
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
T2281 GSK2256098 GSK 2256098,GSK-2256098,GTPL7939 Apoptosis , FAK
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
T5640 GSK2193874 TRP/TRPV Channel
GSK2193874 was identified as a selective, orally active TRPV4 blocker.
T27471 GSK299115A GSK 299115A,GSK-299115A GRK
GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.
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