tpo

Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.

Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.

Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).

Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active small-molecule, nonpeptide thrombopoietin receptor agonist that stimulates megakaryopoiesis. It binds to and activates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), promoting the proliferation and differentiation of megakaryocytic cells and enhancing platelet production.

TPO-L is a photoinitiator used in 3D printing resins, facilitating two-photon induced polymerization. The two-photon absorption cross-section spectrum of Lucirin TPO-L exhibits a peak of 1.2 GM at 610 nm. Although the two-photon absorption cross-section is relatively small, Lucirin TPO-L demonstrates a high polymerization quantum yield.

TPO agonist 1 (TPO mimetic) is an effective thrombopoietin (TPO) agonist that promotes platelet and megakaryocyte production, suitable for thrombocytopenia research.

TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM for CBP and 5.02 μM for BRD4.

(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.

NTPO trisodium induces DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are mitigated by base excision repair (BER) but not by nucleotide excision repair (NER) [1].

Anti-MPL/TPOR/CD110 Antibody (TA136) is a human-derived antibody expressed in CHO cells, targeting MPL/TPOR/CD110. It possesses a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-MPL/TPOR/CD110 Antibody (TA136) is HumanIgG1kappa, Isotype Control.

Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium (TWT-8152) exerts its action by blocking the antigen-mediated calcium ion influx into mast cells.

Molybdenum disulfide (Moly Powder B) is a novel nanomaterial that can be used to synthesize nanoprobes.

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).

Hoet-PO is a hydroxymethylglutaryl-CoA reductase inhibitor.

Selnoflast (potassium) (example 6), is an NLRP3 inhibitor.

MAT-POS-e194df51-1 is an orally active, non-covalent, non-peptide inhibitor of the SARS-CoV-2 main protease (M^pro) with an IC_50 of 37 nM. It exhibits cytotoxicity, showing EC_50 values of 64 nM in A549-ACE2-TMPRSS2 cells and 126 nM in HeLa-ACE2 cells [1].

Meteneprost (U 46785) potassium acts as a cervical dilator by stimulating uterine contractions and widening the cervical canal.

E. coli Extract Polar is a polar lipid extract from Escherichia coli, consisting of phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin, useful for reconstituting membrane proteins.

Rosa roxburghii Tratt polysaccharides is a natural product that can be used in related research in the field of life sciences. Its product number is TN8910.

Acid Phosphatase (ACP), Sweet Potato (Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid Phosphatase, AcPase, Apase) is a biological material or organic compound suitable for life sciences research.

ent-POPC is the enantiomer of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) and can be used in the preparation of lipid nanoparticles for drug delivery.

6PPD-Q-1-OH is an oxidative derivative of the compound 6-PPD-Q, which belongs to the group of oxidized para-phenylenediamines.

MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.