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Cat No. | Product Name | Synonyms | Targets |
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T60026 | KIF18A-IN-2 | Microtubule Associated | |
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T8492 | BO-264 | Apoptosis , FGFR | |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). | |||
T9521 | CHR-6494 TFA | Others | |
CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use... | |||
TQ0317 | R1530 | R-1530,R 1530 | VEGFR , FGFR , FLT , PDGFR |
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities. | |||
T8342 | BRD9876 | Others , Kinesin , Microtubule Associated | |
BRD9876 is a selective inhibitor of MM1S growth. | |||
T16156 | MT 63-78 | Apoptosis , AMPK , mTOR | |
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel... | |||
T6019 | Volasertib | BI 6727 | Apoptosis , PLK |
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). | |||
T9083 | TC11 | CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | BCL , Caspase , CDK |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. | |||
T2241 | Alisertib | MLN 8237 | Apoptosis , Aurora Kinase , Autophagy |
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B. | |||
T6393 | ARQ 621 | Kinesin | |
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. | |||
T3330L | Cis-trismethoxy Resveratrol | (Z)-3,5,4'-Trimethoxystilbene | Microtubule Associated |
cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects. | |||
T11383 | GDP366 | Survivin | |
GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18. | |||
T20506 | Maleuric acid | N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778 | Others |
Maleuric acid (N-Carbamoylmaleamic acid) is anti-mitotic and can be used in biological research in conjunction with radioautography.Maleuric acid is used to improve the growth and fertility of plants and animals as well ... | |||
T4029 | BTB-1 | BTB 1,NSC156750 | Microtubule Associated |
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A. | |||
T4048 | Monastrol | (±)-Monastrol | Apoptosis , Kinesin |
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. | |||
T18867 | Val-Cit-PAB-MMAE | ||
Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerizat... | |||
T15576 | Indibulin | ZIO 301,D 24851 | Apoptosis , Microtubule Associated |
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu... | |||
T3120 | K858 (Racemic) | K858 Racemic,K858 | Apoptosis , Kinesin |
K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner. | |||
T16391 | ON-013100 | CDK | |
ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. | |||
T36816 | S-trityl-L-Cysteine | STLC | Kinesin |
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ... | |||
T2440 | IC261 | SU-5607 | Apoptosis , Casein Kinase , CDK |
IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM. | |||
T67935 | Tubulin inhibitor 11 | Apoptosis , Microtubule Associated | |
Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis . | |||
T9831 | MKC-1 | Ro-31-7453 | Apoptosis , Akt , Microtubule Associated , mTOR |
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format... | |||
T61184 | LQZ-7F | Apoptosis , Survivin | |
LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenogra... | |||
T0500 | Chloroxine | Capitrol | Antibacterial , Antibiotic |
Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epi... | |||
T16987 | TAO Kinase inhibitor 1 | Others , MAPK | |
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectiv... | |||
T10215 | AAPK-25 | Apoptosis , PLK , Aurora Kinase | |
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ... | |||
T2511 | Plinabulin | NPI-2358 | Microtubule Associated |
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the... | |||
T34787 | TAS-119 | TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119 | Aurora Kinase |
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora... | |||
T36674 | DMU-212 | Apoptosis , ERK | |
DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2... | |||
T2090 | Lexibulin | CYT-997 | Apoptosis , Reactive Oxygen Species , Microtubule Associated |
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this... | |||
T9657 | FiVe1 | Others | |
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec... | |||
T21678 | 3MB-PP1 | PLK | |
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi... | |||
T77651 | Tubulin polymerization-IN-47 | Microtubule Associated | |
Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an... | |||
T8561 | Apcin | APC | |
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr... | |||
T19661 | 8-Chloroadenosine | NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 | AMPK |
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch... | |||
T69433 | Myrmicacin | ||
Myrmicacin is an inhibitor of mitotic progression after metaphase. | |||
T10948 | MMAE-d8 | D8-MMAE,D8-Monomethyl auristatin E | Others |
D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE. | |||
T30308 | BDPSB | ||
BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity. | |||
T71584 | Microtubule Inhibitor 185322 | ||
Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells. | |||
T71609 | Hexestrol diphosphate sodium | ||
Hexestrol diphosphate sodium is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation. | |||
TQ0314 | EMD534085 | Kinesin | |
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM). | |||
T29233 | Z-LLNle-CHO | ||
Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. | |||
T4649 | (S)-Monastrol | Kinesin | |
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. | |||
T29101 | VE-465 | ||
VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events. | |||
T24150 | HR22C16 | HR-22-C-16,HR 22 C 16 | |
HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor. | |||
T14906 | CCT251455 | Kinesin | |
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM). | |||
T30794 | Centmitor-1 | Centmitor 1 | |
Centmitor-1 is a novel mitotic inducer that modulates the positive end of microtubules and reduces microtubule dynamics. | |||
T33411 | Mitopodozide | SP-I 77,SPI 77,SPI-77 | |
Mitopodozide, as an ethylhydrazide derivative of podophyllic acid, acts as a mitotic poison in carcinomas of the ovary. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN7041 | (-)-Epipodophyllotoxin | Apoptosis | |
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit... | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T21351 | Maytansine | NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine | Microtubule Associated , Antibiotic |
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. | |||
T19720 | Colcemid | C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine | Microtubule Associated |
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning. | |||
T22455 | Vindesine sulfate | DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule... | |||
T1270 | Vincristine sulfate | Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate | Apoptosis , Microtubule Associated |
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle. | |||
T0190 | Vinorelbine | KW-2307 base | Microtubule Associated |
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. | |||
T0968 | Paclitaxel | Taxol,NSC 125973 | Apoptosis , Microtubule Associated , Autophagy |
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy. | |||
T6213 | Vinorelbine ditartrate | Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate | Microtubule Associated , Autophagy |
Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition. | |||
T6718 | Zingerone | Gingerone,Vanillylacetone,NSC 15335 | NF-κB |
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic and anti-tumor properties. Zingerone(Gi... | |||
T64353 | 4-tert-Octylphenol | Endogenous Metabolite | |
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic drug. 4-tert-Octylphenol induces Apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU),... | |||
TMM2618 | Gibberllin A7 | Gibberellin A7,Gibberllin 7 | Others |
Gibberllin A7 (Gibberllin 7) is important plant growth hormones that promote plant cell growth and elongation. Gebberillins promote rapid stem and root growth, induce mitotic division and initiate (break dormancy) and in... | |||
T32055 | Hemiasterlin | NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin | |
Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation. | |||
TQ0112 | Tubulysin A | TubA | Microtubule Associated |
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic. | |||
T14304 | Aphidicolin | Others | |
Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by i... | |||
T75576 | Solidagonic acid | ||
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles fr... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02238 | MAD2L1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 famil... | |||
TMPY-04125 | PTP1B Protein, Human, Recombinant (His) | Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c... | |||
TMPY-03484 | TCPTP Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1... | |||
TMPY-04774 | ALK-2/ACVR1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-05748 | CD45 Protein, Human, Recombinant (aa 26-577, His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-04376 | PLK1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ... | |||
TMPK-01021 | LY75/CD205 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. In mammals, several cell surface molecular markers have been characterized in order to identify the mitotic germ cells. he ex... | |||
TMPK-01281 | LY75/CD205 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. In mammals, several cell surface molecular markers have been characterized in order to identify the mitotic germ cells. he ex... | |||
TMPH-03438 | CHS1 Protein, S. cerevisiae, Recombinant (His) | Saccharomyces cerevisiae | E. coli |
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation d... | |||
TMPH-01433 | Hemicentin-1 Protein, Human, Recombinant (His) | Human | E. coli |
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. | |||
TMPH-01536 | ITGB4 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. | |||
TMPY-04025 | CEP57 Protein, Human, Recombinant (GST) | Human | E. coli |
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between... | |||
TMPH-01535 | INSIG2 Protein, Human, Recombinant (His & Myc) | Human | in vitro E. coli expression system |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly de... | |||
TMPK-00618 | FcRH5/FcRL5 Protein, Human, Recombinant (His) | Human | HEK293 |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),... | |||
TMPK-01039 | FcRH5/FcRL5 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),... | |||
TMPH-02595 | Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO) | Mouse | E. coli |
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit... | |||
TMPK-00619 | FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),... | |||
TMPK-01145 | FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),... | |||
TMPH-03103 | CDH3/Cadherin 3 Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | Yeast |
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation d... | |||
TMPH-00976 | DDX19A Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly ... | |||
TMPH-01280 | EGLN1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide excha... | |||
TMPH-02069 | Secretogranin-2 Protein, Human, Recombinant (GST & His) | Human | E. coli |
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito... | |||
TMPY-04558 | NEK7 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) pro... | |||
TMPY-03048 | PRAP1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPY-03076 | PRAP1 Protein, Human, Recombinant (His) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPH-02031 | RBL2 Protein, Human, Recombinant (His) | Human | E. coli |
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito... | |||
TMPY-03442 | MOB4A/MOB1B Protein, Human, Recombinant (GST) | Human | E. coli |
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian ... | |||
TMPJ-00465 | PTP1C Protein, Human, Recombinant (His) | Human | E. coli |
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mi... | |||
TMPY-03486 | PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) | Human | Baculovirus-Insect Cells |
PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncog... | |||
TMPJ-01436 | MKI67 Protein, Human, Recombinant (GST) | Human | E. coli |
MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferatio... | |||
TMPJ-00972 | CDKN1B Protein, Human, Recombinant (His) | Human | E. coli |
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele... | |||
TMPY-03296 | SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) | Mouse | Baculovirus-Insect Cells |
PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and onco... | |||
TMPJ-00960 | TMPO Protein, Human, Recombinant (His) | Human | E. coli |
Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domai... | |||
TMPY-03548 | PTPN12 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncog... | |||
TMPJ-01140 | IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His) | Human | E. coli |
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo... | |||
TMPH-02560 | CPS1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction... | |||
TMPH-02279 | YARS1 Protein, Human, Recombinant (GST) | Human | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
TMPH-02278 | PTPN5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
TMPJ-01139 | IA2 Protein, Human, Recombinant (aa 576-950, His) | Human | E. coli |
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo... | |||
TMPJ-01141 | IA2 Protein, Human, Recombinant (aa 687-979, His) | Human | E. coli |
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo... | |||
TMPH-00496 | Osteocalcin Protein, Canine, Recombinant (His & KSI) | Canine | E. coli |
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes inc... | |||
TMPY-04547 | PBK/TOPK Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara... | |||
TMPY-04430 | P38 gamma/MAPK12 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... | |||
TMPY-04429 | P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... | |||
TMPJ-00936 | CCND2 Protein, Human, Recombinant (His) | Human | E. coli |
CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ... | |||
TMPY-04549 | CDK1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote... | |||
TMPY-02369 | TCPTP Protein, Mouse, Recombinant (aa 2-314, His) | Mouse | Baculovirus-Insect Cells |
Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1... | |||
TMPY-04443 | NEK3 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of... | |||
TMPY-02763 | DEP-1 Protein, Human, Recombinant (aa 997-1337, His) | Human | E. coli |
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, includin... | |||
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Cat No. | Product Name | ||
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L8100 | Cell Cycle Compound Library | 695 compounds | |
A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS); |