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Search Results for " mitotic "

Targets

112

Compounds

16

Natural Products

73

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T60026 KIF18A-IN-2 Microtubule Associated
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.
T9595 LP-261 Microtubule Associated
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
T8492 BO-264 Apoptosis , FGFR
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
T9521 CHR-6494 TFA Others
CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use...
TQ0317 R1530 R-1530,R 1530 VEGFR , FGFR , FLT , PDGFR
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
T8342 BRD9876 Others , Kinesin , Microtubule Associated
BRD9876 is a selective inhibitor of MM1S growth.
T16156 MT 63-78 Apoptosis , AMPK , mTOR
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...
T6019 Volasertib BI 6727 Apoptosis , PLK
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).
T9083 TC11 CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 BCL , Caspase , CDK
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T2241 Alisertib MLN 8237 Apoptosis , Aurora Kinase , Autophagy
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.
T6393 ARQ 621 Kinesin
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T3330L Cis-trismethoxy Resveratrol (Z)-3,5,4'-Trimethoxystilbene Microtubule Associated
cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.
T11383 GDP366 Survivin
GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.
T20506 Maleuric acid N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778 Others
Maleuric acid (N-Carbamoylmaleamic acid) is anti-mitotic and can be used in biological research in conjunction with radioautography.Maleuric acid is used to improve the growth and fertility of plants and animals as well ...
T4029 BTB-1 BTB 1,NSC156750 Microtubule Associated
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4048 Monastrol (±)-Monastrol Apoptosis , Kinesin
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T18867 Val-Cit-PAB-MMAE
Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerizat...
T15576 Indibulin ZIO 301,D 24851 Apoptosis , Microtubule Associated
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...
T3120 K858 (Racemic) K858 Racemic,K858 Apoptosis , Kinesin
K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T16391 ON-013100 CDK
ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
T36816 S-trityl-L-Cysteine STLC Kinesin
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ...
T2440 IC261 SU-5607 Apoptosis , Casein Kinase , CDK
IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T67935 Tubulin inhibitor 11 Apoptosis , Microtubule Associated
Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis .
T9831 MKC-1 Ro-31-7453 Apoptosis , Akt , Microtubule Associated , mTOR
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...
T61184 LQZ-7F Apoptosis , Survivin
LQZ-7F is a small molecule survivin dimerisation inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and blocks human tumour growth in mouse xenogra...
T0500 Chloroxine Capitrol Antibacterial , Antibiotic
Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epi...
T16987 TAO Kinase inhibitor 1 Others , MAPK
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectiv...
T10215 AAPK-25 Apoptosis , PLK , Aurora Kinase
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...
T2511 Plinabulin NPI-2358 Microtubule Associated
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...
T34787 TAS-119 TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119 Aurora Kinase
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora...
T36674 DMU-212 Apoptosis , ERK
DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2...
T2090 Lexibulin CYT-997 Apoptosis , Reactive Oxygen Species , Microtubule Associated
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this...
T9657 FiVe1 Others
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec...
T21678 3MB-PP1 PLK
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...
T77651 Tubulin polymerization-IN-47 Microtubule Associated
Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an...
T8561 Apcin APC
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr...
T19661 8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 AMPK
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...
T69433 Myrmicacin
Myrmicacin is an inhibitor of mitotic progression after metaphase.
T10948 MMAE-d8 D8-MMAE,D8-Monomethyl auristatin E Others
D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE.
T30308 BDPSB
BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity.
T71584 Microtubule Inhibitor 185322
Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells.
T71609 Hexestrol diphosphate sodium
Hexestrol diphosphate sodium is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.
TQ0314 EMD534085 Kinesin
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T29233 Z-LLNle-CHO
Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
T4649 (S)-Monastrol Kinesin
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T29101 VE-465
VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.
T24150 HR22C16 HR-22-C-16,HR 22 C 16
HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.
T14906 CCT251455 Kinesin
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T30794 Centmitor-1 Centmitor 1
Centmitor-1 is a novel mitotic inducer that modulates the positive end of microtubules and reduces microtubule dynamics.
T33411 Mitopodozide SP-I 77,SPI 77,SPI-77
Mitopodozide, as an ethylhydrazide derivative of podophyllic acid, acts as a mitotic poison in carcinomas of the ovary.

Compounds

KIF18A-IN-2
T60026
Synonym:
Target: Microtubule Associated
LP-261
T9595
Synonym:
Target: Microtubule Associated
BO-264
T8492
Synonym:
Target: Apoptosis, FGFR
CHR-6494 TFA
T9521
Synonym:
Target: Others
R1530
TQ0317
Synonym: R-1530,R 1530
Target: VEGFR, FGFR, FLT, PDGFR
BRD9876
T8342
Synonym:
Target: Others, Kinesin, Microtubule Associated
MT 63-78
T16156
Synonym:
Target: Apoptosis, AMPK, mTOR
Volasertib
T6019
Synonym: BI 6727
Target: Apoptosis, PLK
TC11
T9083
Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11
Target: BCL, Caspase, CDK
Alisertib
T2241
Synonym: MLN 8237
Target: Apoptosis, Aurora Kinase, Autophagy
ARQ 621
T6393
Synonym:
Target: Kinesin
cis-trismethoxy Resveratrol
T3330L
Synonym: (Z)-3,5,4'-Trimethoxystilbene
Target: Microtubule Associated
GDP366
T11383
Synonym:
Target: Survivin
Maleuric acid
T20506
Synonym: N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778
Target: Others
BTB-1
T4029
Synonym: BTB 1,NSC156750
Target: Microtubule Associated
Monastrol
T4048
Synonym: (±)-Monastrol
Target: Apoptosis, Kinesin
Val-Cit-PAB-MMAE
T18867
Synonym:
Target:
Indibulin
T15576
Synonym: ZIO 301,D 24851
Target: Apoptosis, Microtubule Associated
K858 (Racemic)
T3120
Synonym: K858 Racemic,K858
Target: Apoptosis, Kinesin
ON-013100
T16391
Synonym:
Target: CDK
S-trityl-L-Cysteine
T36816
Synonym: STLC
Target: Kinesin
IC261
T2440
Synonym: SU-5607
Target: Apoptosis, Casein Kinase, CDK
Tubulin inhibitor 11
T67935
Synonym:
Target: Apoptosis, Microtubule Associated
MKC-1
T9831
Synonym: Ro-31-7453
Target: Apoptosis, Akt, Microtubule Associated, mTOR
LQZ-7F
T61184
Synonym:
Target: Apoptosis, Survivin
Chloroxine
T0500
Synonym: Capitrol
Target: Antibacterial, Antibiotic
TAO Kinase inhibitor 1
T16987
Synonym:
Target: Others, MAPK
AAPK-25
T10215
Synonym:
Target: Apoptosis, PLK, Aurora Kinase
Plinabulin
T2511
Synonym: NPI-2358
Target: Microtubule Associated
TAS-119
T34787
Synonym: TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119
Target: Aurora Kinase
DMU-212
T36674
Synonym:
Target: Apoptosis, ERK
Lexibulin
T2090
Synonym: CYT-997
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated
FiVe1
T9657
Synonym:
Target: Others
3MB-PP1
T21678
Synonym:
Target: PLK
Tubulin polymerization-IN-47
T77651
Synonym:
Target: Microtubule Associated
Apcin
T8561
Synonym:
Target: APC
8-Chloroadenosine
T19661
Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258
Target: AMPK
Myrmicacin
T69433
Synonym:
Target:
MMAE-d8
T10948
Synonym: D8-MMAE,D8-Monomethyl auristatin E
Target: Others
BDPSB
T30308
Synonym:
Target:
Microtubule Inhibitor 185322
T71584
Synonym:
Target:
Hexestrol diphosphate sodium
T71609
Synonym:
Target:
EMD534085
TQ0314
Synonym:
Target: Kinesin
Z-LLNle-CHO
T29233
Synonym:
Target:
(S)-Monastrol
T4649
Synonym:
Target: Kinesin
VE-465
T29101
Synonym:
Target:
HR22C16
T24150
Synonym: HR-22-C-16,HR 22 C 16
Target:
CCT251455
T14906
Synonym:
Target: Kinesin
Centmitor-1
T30794
Synonym: Centmitor 1
Target:
Mitopodozide
T33411
Synonym: SP-I 77,SPI 77,SPI-77
Target:
1 2 3
Cat No. Product Name Synonyms Targets
TN7041 (-)-Epipodophyllotoxin Apoptosis
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T21351 Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine Microtubule Associated , Antibiotic
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
T19720 Colcemid C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine Microtubule Associated
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
T22455 Vindesine sulfate DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS Others
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule...
T1270 Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate Apoptosis , Microtubule Associated
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.
T0190 Vinorelbine KW-2307 base Microtubule Associated
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.
T0968 Paclitaxel Taxol,NSC 125973 Apoptosis , Microtubule Associated , Autophagy
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
T6213 Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate Microtubule Associated , Autophagy
Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6718 Zingerone Gingerone,Vanillylacetone,NSC 15335 NF-κB
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic and anti-tumor properties. Zingerone(Gi...
T64353 4-tert-Octylphenol Endogenous Metabolite
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic drug. 4-tert-Octylphenol induces Apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU),...
TMM2618 Gibberllin A7 Gibberellin A7,Gibberllin 7 Others
Gibberllin A7 (Gibberllin 7) is important plant growth hormones that promote plant cell growth and elongation. Gebberillins promote rapid stem and root growth, induce mitotic division and initiate (break dormancy) and in...
T32055 Hemiasterlin NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin
Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.
TQ0112 Tubulysin A TubA Microtubule Associated
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
T14304 Aphidicolin Others
Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by i...
T75576 Solidagonic acid
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles fr...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02238 MAD2L1 Protein, Human, Recombinant (His) Human E. coli
Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 famil...
TMPY-04125 PTP1B Protein, Human, Recombinant (His) Human E. coli
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPY-03484 TCPTP Protein, Human, Recombinant Human Baculovirus-Insect Cells
Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1...
TMPY-04774 ALK-2/ACVR1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been...
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05748 CD45 Protein, Human, Recombinant (aa 26-577, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-04376 PLK1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ...
TMPK-01021 LY75/CD205 Protein, Mouse, Recombinant (His) Mouse HEK293
Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. In mammals, several cell surface molecular markers have been characterized in order to identify the mitotic germ cells. he ex...
TMPK-01281 LY75/CD205 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. In mammals, several cell surface molecular markers have been characterized in order to identify the mitotic germ cells. he ex...
TMPH-03438 CHS1 Protein, S. cerevisiae, Recombinant (His) Saccharomyces cerevisiae E. coli
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation d...
TMPH-01433 Hemicentin-1 Protein, Human, Recombinant (His) Human E. coli
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
TMPH-01536 ITGB4 Protein, Human, Recombinant (His & Myc) Human E. coli
Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
TMPY-04025 CEP57 Protein, Human, Recombinant (GST) Human E. coli
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between...
TMPH-01535 INSIG2 Protein, Human, Recombinant (His & Myc) Human in vitro E. coli expression system
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly de...
TMPK-00618 FcRH5/FcRL5 Protein, Human, Recombinant (His) Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-01039 FcRH5/FcRL5 Protein, Mouse, Recombinant (His) Mouse HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPH-02595 Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO) Mouse E. coli
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit...
TMPK-00619 FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPK-01145 FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),...
TMPH-03103 CDH3/Cadherin 3 Protein, Pig, Recombinant (His) Sus scrofa (Pig) Yeast
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation d...
TMPH-00976 DDX19A Protein, Human, Recombinant (His & SUMO) Human E. coli
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly ...
TMPH-01280 EGLN1 Protein, Human, Recombinant (His & Myc) Human E. coli
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide excha...
TMPH-02069 Secretogranin-2 Protein, Human, Recombinant (GST & His) Human E. coli
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito...
TMPY-04558 NEK7 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) pro...
TMPY-03048 PRAP1 Protein, Human, Recombinant (mFc) Human HEK293
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPY-03076 PRAP1 Protein, Human, Recombinant (His) Human HEK293
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPH-02031 RBL2 Protein, Human, Recombinant (His) Human E. coli
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito...
TMPY-03442 MOB4A/MOB1B Protein, Human, Recombinant (GST) Human E. coli
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian ...
TMPJ-00465 PTP1C Protein, Human, Recombinant (His) Human E. coli
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mi...
TMPY-03486 PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) Human Baculovirus-Insect Cells
PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncog...
TMPJ-01436 MKI67 Protein, Human, Recombinant (GST) Human E. coli
MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferatio...
TMPJ-00972 CDKN1B Protein, Human, Recombinant (His) Human E. coli
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele...
TMPY-03296 SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) Mouse Baculovirus-Insect Cells
PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and onco...
TMPJ-00960 TMPO Protein, Human, Recombinant (His) Human E. coli
Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domai...
TMPY-03548 PTPN12 Protein, Human, Recombinant Human Baculovirus-Insect Cells
PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncog...
TMPJ-01140 IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His) Human E. coli
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo...
TMPH-02560 CPS1 Protein, Mouse, Recombinant (His) Mouse E. coli
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction...
TMPH-02279 YARS1 Protein, Human, Recombinant (GST) Human E. coli
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin...
TMPH-02278 PTPN5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin...
TMPJ-01139 IA2 Protein, Human, Recombinant (aa 576-950, His) Human E. coli
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo...
TMPJ-01141 IA2 Protein, Human, Recombinant (aa 687-979, His) Human E. coli
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendo...
TMPH-00496 Osteocalcin Protein, Canine, Recombinant (His & KSI) Canine E. coli
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes inc...
TMPY-04547 PBK/TOPK Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
TMPY-04430 P38 gamma/MAPK12 Protein, Human, Recombinant Human Baculovirus-Insect Cells
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t...
TMPY-04429 P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t...
TMPJ-00936 CCND2 Protein, Human, Recombinant (His) Human E. coli
CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...
TMPY-04549 CDK1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPY-02369 TCPTP Protein, Mouse, Recombinant (aa 2-314, His) Mouse Baculovirus-Insect Cells
Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1...
TMPY-04443 NEK3 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of...
TMPY-02763 DEP-1 Protein, Human, Recombinant (aa 997-1337, His) Human E. coli
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, includin...
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MAD2L1 Protein, Human, Recombinant (His)
TMPY-02238
Species: Human
Expression System: E. coli
PTP1B Protein, Human, Recombinant (His)
TMPY-04125
Species: Human
Expression System: E. coli
TCPTP Protein, Human, Recombinant
TMPY-03484
Species: Human
Expression System: Baculovirus-Insect Cells
ALK-2/ACVR1 Protein, Human, Recombinant (His)
TMPY-04774
Species: Human
Expression System: Baculovirus-Insect Cells
CD45 Protein, Human, Recombinant (aa 1-529, His)
TMPY-05308
Species: Human
Expression System: HEK293
CD45 Protein, Human, Recombinant (aa 26-577, His)
TMPY-05748
Species: Human
Expression System: HEK293
PLK1 Protein, Human, Recombinant (His)
TMPY-04376
Species: Human
Expression System: Baculovirus-Insect Cells
LY75/CD205 Protein, Mouse, Recombinant (His)
TMPK-01021
Species: Mouse
Expression System: HEK293
LY75/CD205 Protein, Cynomolgus, Recombinant (His)
TMPK-01281
Species: Cynomolgus
Expression System: HEK293
CHS1 Protein, S. cerevisiae, Recombinant (His)
TMPH-03438
Species: Saccharomyces cerevisiae
Expression System: E. coli
Hemicentin-1 Protein, Human, Recombinant (His)
TMPH-01433
Species: Human
Expression System: E. coli
ITGB4 Protein, Human, Recombinant (His & Myc)
TMPH-01536
Species: Human
Expression System: E. coli
CEP57 Protein, Human, Recombinant (GST)
TMPY-04025
Species: Human
Expression System: E. coli
INSIG2 Protein, Human, Recombinant (His & Myc)
TMPH-01535
Species: Human
Expression System: in vitro E. coli expression system
FcRH5/FcRL5 Protein, Human, Recombinant (His)
TMPK-00618
Species: Human
Expression System: HEK293
FcRH5/FcRL5 Protein, Mouse, Recombinant (His)
TMPK-01039
Species: Mouse
Expression System: HEK293
Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO)
TMPH-02595
Species: Mouse
Expression System: E. coli
FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00619
Species: Human
Expression System: HEK293
FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01145
Species: Human
Expression System: HEK293
CDH3/Cadherin 3 Protein, Pig, Recombinant (His)
TMPH-03103
Species: Sus scrofa (Pig)
Expression System: Yeast
DDX19A Protein, Human, Recombinant (His & SUMO)
TMPH-00976
Species: Human
Expression System: E. coli
EGLN1 Protein, Human, Recombinant (His & Myc)
TMPH-01280
Species: Human
Expression System: E. coli
Secretogranin-2 Protein, Human, Recombinant (GST & His)
TMPH-02069
Species: Human
Expression System: E. coli
NEK7 Protein, Human, Recombinant (His & GST)
TMPY-04558
Species: Human
Expression System: Baculovirus-Insect Cells
PRAP1 Protein, Human, Recombinant (mFc)
TMPY-03048
Species: Human
Expression System: HEK293
PRAP1 Protein, Human, Recombinant (His)
TMPY-03076
Species: Human
Expression System: HEK293
RBL2 Protein, Human, Recombinant (His)
TMPH-02031
Species: Human
Expression System: E. coli
MOB4A/MOB1B Protein, Human, Recombinant (GST)
TMPY-03442
Species: Human
Expression System: E. coli
PTP1C Protein, Human, Recombinant (His)
TMPJ-00465
Species: Human
Expression System: E. coli
PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST)
TMPY-03486
Species: Human
Expression System: Baculovirus-Insect Cells
MKI67 Protein, Human, Recombinant (GST)
TMPJ-01436
Species: Human
Expression System: E. coli
CDKN1B Protein, Human, Recombinant (His)
TMPJ-00972
Species: Human
Expression System: E. coli
SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)
TMPY-03296
Species: Mouse
Expression System: Baculovirus-Insect Cells
TMPO Protein, Human, Recombinant (His)
TMPJ-00960
Species: Human
Expression System: E. coli
PTPN12 Protein, Human, Recombinant
TMPY-03548
Species: Human
Expression System: Baculovirus-Insect Cells
IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His)
TMPJ-01140
Species: Human
Expression System: E. coli
CPS1 Protein, Mouse, Recombinant (His)
TMPH-02560
Species: Mouse
Expression System: E. coli
YARS1 Protein, Human, Recombinant (GST)
TMPH-02279
Species: Human
Expression System: E. coli
PTPN5 Protein, Human, Recombinant (His & SUMO)
TMPH-02278
Species: Human
Expression System: E. coli
IA2 Protein, Human, Recombinant (aa 576-950, His)
TMPJ-01139
Species: Human
Expression System: E. coli
IA2 Protein, Human, Recombinant (aa 687-979, His)
TMPJ-01141
Species: Human
Expression System: E. coli
Osteocalcin Protein, Canine, Recombinant (His & KSI)
TMPH-00496
Species: Canine
Expression System: E. coli
PBK/TOPK Protein, Human, Recombinant (His)
TMPY-04547
Species: Human
Expression System: Baculovirus-Insect Cells
p38 gamma/MAPK12 Protein, Human, Recombinant
TMPY-04430
Species: Human
Expression System: Baculovirus-Insect Cells
p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)
TMPY-04429
Species: Human
Expression System: Baculovirus-Insect Cells
CCND2 Protein, Human, Recombinant (His)
TMPJ-00936
Species: Human
Expression System: E. coli
CDK1 Protein, Human, Recombinant (GST)
TMPY-04549
Species: Human
Expression System: Baculovirus-Insect Cells
TCPTP Protein, Mouse, Recombinant (aa 2-314, His)
TMPY-02369
Species: Mouse
Expression System: Baculovirus-Insect Cells
NEK3 Protein, Mouse, Recombinant (His & GST)
TMPY-04443
Species: Mouse
Expression System: Baculovirus-Insect Cells
DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
TMPY-02763
Species: Human
Expression System: E. coli
Cat No. Product Name
L8100 Cell Cycle Compound Library

695 compounds
A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
TargetMol