pim — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2253	TCS PIM-1 1	SC 204330	Pim
	TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM).		Pim
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T9229	Pim-1/2 kinase inhibitor 1		Pim
	Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ...		Pim
T83627	Pim-1 kinase inhibitor 8		Pim , PKC
	Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ...		Pim , PKC
T77526	Pim-1 kinase inhibitor 4		Apoptosis , Pim
	Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and potential anticancer activity, and inhibits DPPH.Pim-1 kinase in...		Apoptosis , Pim
T3058	(Z)-SMI-4a	TCS PIM-1 4a,SMI-4a	Pim
	(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.		Pim
T40319	PIM-IN-1
	PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).
T3078	SGI-1776	SGI-1776 free base,Pim-Kinase Inhibitor IX	Apoptosis , FLT , Pim , Autophagy
	SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.		Apoptosis , FLT , Pim , Autophagy
T6148	CX-6258 hydrochloride	CX-6258 HCl,Pim-Kinase Inhibitor X	Pim
	CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).		Pim
T40092	MNK/PIM-IN-1
	MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.
T12473	PIM-447 dihydrochloride	LGH447 dihydrochloride	Others
	PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).		Others
T23158	PIM-1 Inhibitor 2		Others
	PIM-1 Inhibitor 2 is an effective Pim-1 kinase inhibitor (Ki = 91 nM).		Others
T71558	Pim-IN-14j
	Pim-IN-14j is a potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases.
TQ0201	Hispidulin	Dinatin	Pim
	Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).		Pim
T81460	PIM-IN-2		Pim
	PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM . It exhibits antiapoptotic properties conducive to cell survival and has been found to ...		Pim
T8114	Quercetagetin	6-Hydroxyquercetin	Pim
	Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).		Pim
T4523	TP-3654		Pim
	TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).		Pim
T62001	Pim-1 kinase inhibitor 2
	Pim-1 kinase inhibitor 2 (Compound 13), a potent inhibitor of Pim-1 kinase, has the potential for cancer research due to its ability to induce apoptosis [1].
T78980	Pim-1 kinase inhibitor 5		Pim
	Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-116, with IC50 values ranging from 6.95 to 20.19 μM [1].		Pim
T61074	Pim-1 kinase inhibitor 3
	Pim-1 kinase inhibitor 3 (Compound H5) is a potent inhibitor of Pim-1 kinase, demonstrating an inhibitory concentration (IC50) of 35.13 nM [1].