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Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

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Species
Canine (8)
Cavia porcellus (1)
Cynomolgus (60)
Human (196)
Marmoset (1)
Mouse (80)
Rabbit (2)
Rat (25)
Rhesus (24)
Rhesus Macaque (2)
Rhesus macaque (7)
Source
Baculovirus-Insect Cells (5)
CHO (1)
E. coli (5)
HEK293 (319)
Human Cells (61)
P. pastoris (1)
Label
AVI (34)
C-6His (25)
C-6His-Avi (3)
C-Avi (4)
C-Avi-6His (5)
C-Fc (14)
C-Fc-6His (2)
C-Fc-Avi (5)
C-Flag (3)
C-GST (1)
C-His (17)
C-His-Avi (27)
C-hFc (7)
C-hFc-Avi (3)
C-mFc (2)
Fc (1)
His (138)
N-6His-Flag (1)
N-8His (1)
N-Flag (7)
N-GST (2)
N-His-Avi (7)
N-hFc (1)
N-hFc-Flag (1)
Tag Free (12)
hFc (98)
mFc (14)
rFc (2)
Cat No. product name / Synonyms Species Source
TMPJ-00063 CD160 Protein, Human, Recombinant (hFc)
CD160 Protein, Human, Recombinant (hFc)
Human Human Cells
CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine...
TMPJ-00107 CTLA-4 Protein, Human, Recombinant (Flag)
CTLA-4 Protein, Human, Recombinant (Flag)
Human Human Cells
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA enc...
TMPJ-00108 CTLA-4 Protein, Human, Recombinant (GST)
CTLA-4 Protein, Human, Recombinant (GST)
Human Human Cells
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA enc...
TMPJ-00129 BTLA Protein, Human, Recombinant (His)
BTLA Protein, Human, Recombinant (His)
Human Human Cells
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induc...
TMPJ-00173 TIM-3 Protein, Mouse, Recombinant (aa 20-191, His)
TIM-3 Protein, Mouse, Recombinant (aa 20-191, His)
Mouse Human Cells
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of...
TMPJ-00174 TIM-3 Protein, Mouse, Recombinant (aa 20-193, His)
TIM-3 Protein, Mouse, Recombinant (aa 20-193, His)
Mouse Human Cells
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of...
TMPJ-00175 B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
Rhesus macaque Human Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas,...
TMPJ-00176 B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human Human Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellula...
TMPJ-00179 LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
Human Human Cells
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear c...
TMPJ-00181 PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-...
TMPJ-00182 PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human Human Cells
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin ...
TMPJ-00183 PD-L1 Protein, Human, Recombinant (Flag)
PD-L1 Protein, Human, Recombinant (Flag)
Human Human Cells
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin ...
TMPJ-00187 CD300A Protein, Human, Recombinant (hFc & His)
CD300A Protein, Human, Recombinant (hFc & His)
Human Human Cells
CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of...
TMPJ-00189 TIM-3 Protein, Cynomolgus, Recombinant (His)
TIM-3 Protein, Cynomolgus, Recombinant (His)
Cynomolgus Human Cells
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)ex...
TMPJ-00195 FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
Cynomolgus Human Cells
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
TMPJ-00197 FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human Human Cells
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
TMPJ-00198 FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
Human Human Cells
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
TMPJ-00203 Galectin-9 Protein, Human, Recombinant (GST)
Galectin-9 Protein, Human, Recombinant (GST)
Human E. coli
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galect...
TMPJ-00208 CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human Human Cells
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
TMPJ-00209 CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
Human Human Cells
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
CD160 Protein, Human, Recombinant (hFc)
TMPJ-00063
CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine...
CTLA-4 Protein, Human, Recombinant (Flag)
TMPJ-00107
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA enc...
CTLA-4 Protein, Human, Recombinant (GST)
TMPJ-00108
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA enc...
BTLA Protein, Human, Recombinant (His)
TMPJ-00129
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induc...
TIM-3 Protein, Mouse, Recombinant (aa 20-191, His)
TMPJ-00173
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of...
TIM-3 Protein, Mouse, Recombinant (aa 20-193, His)
TMPJ-00174
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of...
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
TMPJ-00175
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas,...
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00176
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellula...
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
TMPJ-00179
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear c...
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-...
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00182
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin ...
PD-L1 Protein, Human, Recombinant (Flag)
TMPJ-00183
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin ...
CD300A Protein, Human, Recombinant (hFc & His)
TMPJ-00187
CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of...
TIM-3 Protein, Cynomolgus, Recombinant (His)
TMPJ-00189
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)ex...
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
TMPJ-00195
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00197
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00198
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
Galectin-9 Protein, Human, Recombinant (GST)
TMPJ-00203
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galect...
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00208
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00209
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
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TargetMol