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Hydrocortisone Valerate

Name: Hydrocortisone Valerate
Brand: TargetMol
SKU: T0276
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0276Cas No. 57524-89-7

Alias Westcort

Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.

Hydrocortisone Valerate

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🥰Excellent

Purity: 99.94%

Catalog No. T0276Alias WestcortCas No. 57524-89-7

Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	In Stock	In Stock
25 mg	$63	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$180	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Hydrocortisone Valerate AI Summary

Hydrocortisone Valerate shows a wide range of bioactivities across various biological assays. It demonstrates the ability to inhibit DNA re-replication in MCF 10a normal breast cells, modulate miRNAs and activate miR-21, and inhibit enzymes and pathways such as Cruzain, Hypoxia Response Element Signaling Pathway, Nrf2, Chronic Active B-Cell Receptor Signaling, ELG1-dependent DNA repair, malarial parasite plastid, Polymerase Iota, and Cell Surface uPA Generation. It also acts as an antagonist in the Hypoxia Response Element Signaling Pathway and blocks Ebola Virus entry through various channels. Moreover, Hydrocortisone Valerate exhibits antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells with an inhibition rate of -2.87% at 10 µM after 48 hours, and shows 5.809% inhibition against the SARS-CoV-2 3CL-Pro protease at 20 µM. It also inhibits SARS-CoV-2-induced cytotoxicity in VERO-6 cells with an inhibition rate of 0.09% at 10 µM concentration after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.
Synonyms	Westcort

Chemical Properties

Molecular Weight	446.58
Formula	C₂₆H₃₈O₆
Cas No.	57524-89-7
Smiles	O(C(CCCC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])[H]
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (33.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2392 mL	11.1962 mL	22.3924 mL	111.9620 mL
5 mM	0.4478 mL	2.2392 mL	4.4785 mL	22.3924 mL
10 mM	0.2239 mL	1.1196 mL	2.2392 mL	11.1962 mL
20 mM	0.1120 mL	0.5598 mL	1.1196 mL	5.5981 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc