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SelDeg51
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Catalog No. T219265 Copy Product Info
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SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a maximum degradation (Dmax) of 90%. It induces proteasomal degradation of FKBP51 via the formation of the KBP51:SelDeg51:VCB ternary complex, thereby reactivating the glucocorticoid receptor signaling pathway. SelDeg51 is applicable in research on stress-related psychiatric disorders, chronic pain, and obesity.
SelDeg51
Cas No. 3036372-80-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SelDeg51 is a selective FKBP51 PROTAC degrader with a Kd value of 18 nM and a maximum degradation (Dmax) of 90%. It induces proteasomal degradation of FKBP51 via the formation of the KBP51:SelDeg51:VCB ternary complex, thereby reactivating the glucocorticoid receptor signaling pathway. SelDeg51 is applicable in research on stress-related psychiatric disorders, chronic pain, and obesity. |
| Targets & IC50 | FKBP51:18 nM (Kd) |
| In vitro | SelDeg51 (0.6-10 μM; 0-48 h) can degrade FKBP51 in a time-dependent and reversible manner in HEK293T cells, while showing high selectivity for FKBP12. Additionally, SelDeg51 (250 nM) enhances the expression of endogenous glucocorticoid receptor target genes GILZ and FKBP5 in Dexamethasone-induced A549 cells. |
| Molecular Weight | 1343.60 |
| Formula | C72H91FN8O14S |
| Cas No. | 3036372-80-9 |
| Smiles | [C@@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC=C(OCC4=CN(CCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)[C@](C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C8=C(C)N=CS8)N=N4)C=C3)=O)CCCC1)(C9=CC(OC)=C(OC)C(OC)=C9)C%10CCCCC%10 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SelDeg51 in vitro | SelDeg51 formula | SelDeg51 molecular weight
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