z-3

JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.

GypenosideZ-3 is a natural product that can be used in related research in the field of life sciences. Its product number is TN8549.

Z3-Dodecenyl E2-butenoate, a female sex pheromone of the sweet potato weevil (C. formicarius), is utilized for baiting and trapping male sweet potato weevils. This method aids in managing their populations in agricultural fields while minimizing insecticide use.

PTZ-343 is a potent enhancer of Luminol, acting as an electron transfer mediator. It reacts with HRP-II to release HRP and a PTZ-343 radical, which then oxidizes luminol anions to induce light emission.

AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).

IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.

Z-321 is an inhibitor of prolyl endopeptidase.

YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.

PZ-3022 is an orally active, conformational PanK activator that counteracts C3-CoA inhibition. In a mouse model of propionic acidemia, it elevates hepatic CoASH and C2-CoA levels while reducing C3-CoA, making it useful for studying mitochondrial defects in propionic acidemia.

CJZ-3, a derivative of Lomefloxacin, exhibits significant in vitro inhibition of P-gp function. It enhances the intracellular accumulation of Rh123 in a time-dependent manner and markedly reduces Rh123 efflux from cells.

Z-3578 is a small molecule antagonist targeting the MrgX2 (Mas-related G protein-coupled receptor X2) with notable anti-pseudoallergic properties, exhibiting a KD value of 729 nM. It effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, with IC50 values of 4.90 µM and 6.18 µM, respectively, suppresses the release of β-hexosaminidase, and significantly reduces the release of histamine and TNF-α, as well as intracellular calcium flux. Additionally, in a mouse pseudoallergy model, Z-3578 significantly alleviates foot swelling, dye leakage, and reduces serum histamine levels, indicating a strong in vivo anti-allergic effect. Z-3578 presents as a promising lead compound in the field of anti-allergic treatments, particularly for pseudoallergic reactions.

KDRLKZ-3 is a selective E3 ligase. Acting as a ligand for KLHDC2, it demonstrates an IC50 value of 4.1 μM in the alphaLISA assay.

FAZ-3780 (compound G3Ib) is an inhibitor that binds to the NTF2L domain of G3BP1/2, exhibiting a binding affinity to G3BP1 with a Kd of 0.54 μM. It specifically targets the protein-protein interaction domain of G3BP1/2 and inhibits the co-condensation of G3BP1, caprin 1, and RNA in vitro.

YZ-35 is a STAT3 inhibitor with a Ki value of 0.38 μM. It binds directly to STAT3 with high affinity, having a dissociation constant (Kd) of 190 nM. YZ-35 effectively inhibits the dual phosphorylation of STAT3 at Tyr705 and Ser727 sites. It also suppresses colony formation, cell migration, and induces apoptosis in breast cancer cell lines. Additionally, YZ-35 selectively inhibits the self-renewal capability of breast cancer stem cells (BCSC) and reduces tumor growth in breast cancer stem cell xenograft models. YZ-35 is applicable for breast cancer research.

FAZ-3532 is a potent G3BP inhibitor that binds to G3BP1 with a dissociation constant (Kd) of 0.54 μM, inhibiting the co-condensation of G3BP1, Caprin1, and RNA, and preventing the formation of intracellular stress granules. It selectively targets the protein-protein interactions within the G3BP1 NTF2L domain without affecting its dimerization or RNA binding, making it an effective tool for studying the immunological role of stress granules during viral infections.

Z-335 Salt, a thromboxane A2 receptor antagonist, is used potentially for the treatment of arterial occlusive disease.

1-Cbz-3-Hydroxyazetidine (catalog number: T66502, CAS number: 128117-22-6) is a valuable organic compound for life sciences research.

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).

DIZ-3, a selective multimeric G-quadruplex (G4) ligand, employs a G4-ligand-dimerizing approach to intercalate into the G4-G4 interface, thereby stabilizing its higher-order structure. This compound effectively induces cell cycle arrest and apoptosis, inhibiting cell proliferation in cancer cells characterized by alternative lengthening of telomeres (ALT) [1].

SZ-3, a cofilin inhibitor, reduces cofilin expression and protects SH-SY5Y cells from thrombin-induced cell death. Additionally, SZ-3 decreases microglial migration and proliferation and reduces inflammatory cytokine release [1].

N4-Bz-3'-O-DMTr-2'-deoxycytidine 5'-O-CE-phosphoramidite is a Nucleoside Phosphoramidite.

AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.

DCZ3301 is a novel aryl-guanidino inhibitor.

Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.