entry — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8701	GRP-60367		Others
	GRP-60367 is the first small molecule rabies virus (RABV) entry inhibitor, which has nanomolar effect on some RABV strains.		Others
T9231	Mbx2329		Antiviral
	MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits H1N1 virus strain high pathogenic avian influenza H5N1 virus strain.		Antiviral
T8793	CBS1117		Influenza Virus
	CBS1117 is a virus entry inhibitor (IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1)）. It interferes with the hemagglutinin (HA)-mediated fusion process.		Influenza Virus
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T9717	Chlorcyclizine		HCV Protease , Histamine Receptor
	CHLORCYCLIZINE is a histamine H1 antagonist and a potent hepatitis C virus (HCV) entry inhibitor.		HCV Protease , Histamine Receptor
T24141	HIV-1 Inhibitor 18A	HIV-1 Inhibitor-18A	HIV Protease
	HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) specifically inhibits the entry of multiple HIV-1 isolates.		HIV Protease
T6256	YYA-021	YYA 021	gp120/CD4 , HIV Protease
	YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.		gp120/CD4 , HIV Protease
T35373L	Bulevirtide (Myrcludex B) acetate		HBV
	Bulevirtide (Myrcludex B) acetate is a virion entry inhibitor which blocks the virion's hepatocyte pathway of entry, the hepatic sodium/taurocholate cotransporting polypeptide (NTCP) receptor. Bulevirtide (Myrcludex B) a...		HBV
T16688	Pyr6	N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide	TRP/TRPV Channel
	Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 ...		TRP/TRPV Channel
T19719	TBMP	butylated hydroxyanisole	Others
	TBMP (butylated hydroxyanisole) is the viral envelope protein hemagglutinin (HA)-mediated entry novel inhibitor.		Others
T13047	Synta66		Calcium Channel
	Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.		Calcium Channel
T24984	5J-4		Calcium Channel
	5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.		Calcium Channel
T13684	Equilin	7-Dehydroestrone	Calcium Channel
	Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by...		Calcium Channel
T6016	Maraviroc	Celsentri,UK-427857,Selzentry	HIV Protease , CCR
	Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.		HIV Protease , CCR
T3052	Sancycline	Bonomycin,Norcycline,Sancyclinum,6-Demethyl-6-deoxytetracycline	Antibacterial
	Sancycline (Bonomycin) is a rare semi-synthetic tetracycline, acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.		Antibacterial
T15641	K777	APC-3316	P450 , Cysteine Protease , CCR
	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ...		P450 , Cysteine Protease , CCR
T11287	Filipin complex		Antifungal
	Filipin complex is a 28-membered cyclopentene macrolide antifungal antibiotic produced by a mixture of S. filipinensis, S. avermitilis, and S. miharaensis that inhibits the entry of PRRSV viruses into cells.		Antifungal
T8502	N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide		Influenza Virus
	N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide inhibiting the entry of Ebola virus in host cells by binding to the surface glycoprotein, the compound inhibited the Ebola virus with EC50 of 3.9 μM.		Influenza Virus
T26357	Pitstop 2		Apoptosis
	Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec...		Apoptosis
T60085	MM3122	GTPL11533,MM-3122,Ac-GQFR-kbt	SARS-CoV
	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.		SARS-CoV