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  • Inhibitors & Agonists
    218
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
NSC 617145
NSC-617145, NSC617145
T9168203115-63-3
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
  • $31
In Stock
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Calf thymus DNA
DNA from calf thymus, Thymonucleic acid
T1359291080-16-9
Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) is a high-quality double-stranded template DNA extracted from the bovine thymus gland, widely used in studying DNA binding anticancer agents and DNA binding agents that regulate DNA structure and function.
  • $33
In Stock
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TargetMol | Inhibitor Hot
Prexasertib
LY2606368
T43101234015-52-1
Prexasertib (LY2606368) is a selective checkpoint kinase 1 (CHK1) inhibitor (Ki 0.9 nM, IC50<1 nM). Prexasertib causes double-stranded DNA breaks and replication mutations, leading to apoptosis. Prexasertib has antitumor activity.
  • $46
In Stock
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BI-4020
T105342664214-60-0In house
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM). BI-4020 also shows high kinome selectivity and good DMPK properties.
  • $173
In Stock
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EGFR-IN-9
T111631226549-39-8In house
EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R T790M). EGFR-IN-9 has antitumor activity.
  • $48
In Stock
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PF-06459988
T164921428774-45-1In house
PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.
  • $149
5 days
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WR99210 hydrochloride(47326-86-3 free base)
WR99210 hydrochloride(47326-86-3 free base), 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
T17257L30711-93-4In house
WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
  • $85
In Stock
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Lifarizine
RS-87476-000, RS-87476, RS87476, RS 87476-000, RS 87476
T27830119514-66-8In house
Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.
  • $146
In Stock
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Polyinosinic-polycytidylic acid sodium
Poly(I:C) sodium
T1251642424-50-0
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).
  • $30
In Stock
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2'-Deoxyadenosine
NSC-141848, NSC141848, NSC 141848
T20041958-09-8
2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.
  • $39
In Stock
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Benzylideneaniline
N-Benzylideneaniline
T20318538-51-2
Benzylideneaniline (N-Benzylideneaniline) is a potent inhibitor of xyloglucan-α,β-dioxygenase, a key enzyme in the oxidative cleavage of the central double bond of xyloglucan.
  • $30
In Stock
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TargetMol | Inhibitor Sale
Methyl (2E)-2-hexenoate
Methyl(E)-hex-2-enoate
T20382613894-63-8
Methyl (2E)-2-hexenoate is an organic ester containing a double bond and is commonly used in flavor preparation, organic synthesis and biochemical experiments.
  • $195
In Stock
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Allyl propyl disulfide
3-(propyldisulfanyl)prop-1-ene, 1-Allyl-2-propyldisulfane
T2038752179-59-1
Allyl propyl disulfide is an organic compound with a double bond and a disulfide group that is used in organic synthesis and biochemical experiments.
  • $30
In Stock
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2-methylpent-2-enal
2-methyl-2-pentenal
T203888623-36-9
2-methylpent-2-enal is an aldehyde containing a double bond and is commonly used in flavor preparation, organic synthesis and biochemical experiments.
  • $30
In Stock
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Ethyl (2E)-hex-2-enoate
Ethyl trans-2-hexenoate
T20390327829-72-7
Ethyl (2E)-hex-2-enoate (Ethyl trans-2-hexenoate) is an ester containing a double bond and is commonly used in flavor preparation, organic synthesis and biochemical experiments.
  • $29
In Stock
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6-Thioguanosine
NSC-29422, NSC29422, NSC 29422, 6-Mercaptoguanosine
T2051185-31-4
6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double helix.
  • $35
In Stock
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Pyrimidine
Metadiazine
T4809289-95-2
Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and thymidine respectively), or deoxyribose-containing deoxynucleosides, and their corresponding ribonucleotides or deoxyribonucleotides. Pyrimidines serve essential functions in human metabolism as ribonucleotide bases in RNA (uracil and cytosine), and as deoxyribonucleotide bases in DNA (cytosine and thymine), and are linked by phosphodiester bridges to purine nucleotides in double-stranded DNA, in both the nucleus and the mitochondria. Pyrimidine activated sugars are also involved in polysaccharide and phospholipid synthesis, glucuronidation in detoxification processes, glycosylation of proteins and lipids and in the recently identified novel endothelium-derived vasoactive dinucleotides.
  • $29
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4,4'-Disulfanediylbis(2-aminobutanoic acid)
DL-Homocystine
T5276462-10-2
4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) is the double-bonded form of homocysteine that occurs transiently before being converted to harmless cystathionine via a vitamin B6-dependent enzyme. Homocystine and homocysteine-cysteine mixed disulfide account for over 98% of total homocysteine in plasma from healthy individuals.
  • $29
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Irinotecan
Topotecin, CPT-11, (+)-Irinotecan
T622897682-44-5
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.
  • $29
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Leu-Leu-OH
L-Leucyl-L-leucine
T652403303-31-9
Leu-Leu-OH is a derivative dipeptide of leucine that can be used to study the function of the double leucine motif, is present as a metabolite in the human body, and is also detected in certain bacteria (e.g. Mycoplasma genitalium).
  • $37
In Stock
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1-Penten-3-ol
Pent-1-en-3-ol
TN6958616-25-1
1-Penten-3-ol is an organic compound containing a double bond and a hydroxyl group, widely used in biochemical experiments and drug synthesis research.
  • $33
In Stock
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6,10-Dimethylundeca-3,5,9-trien-2-one
Pseudoionone, Citrylideneacetone
TN9555141-10-6
6,10-Dimethylundeca-3,5,9-trien-2-one is a ketone with multiple double bonds, widely used in biochemical experiments and drug synthesis research.
    Inquiry
    EGFR-IN-2
    T111591643497-70-4
    EGFR-IN-2 is a non-covalent, orally available and mutation-selective EGFR inhibitor for the treatment of non-small cell lung cancer (NSCLC), with high selectivity for resistant single and double mutant T790M with IC50 = 27 nm to 33 nM, and low inhibitory activity for wild-type H292 (IC50 = 218 nM).
    • $293
    In Stock
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    Benzoquinoquinoxaline
    BQQ
    T61664207671-99-6
    Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with aminoalkyl side chains containing benzo and quinoline ring structures.BQQ is triple-helix specific stabilizing compounds by preferentially binding to DNA triple junctions and inserting between the bases.Complexes of BQQ with 1,10-phenanthroline are able to bind specifically to and cleave double-stranded DNA at the cleave double-stranded DNA at sites that form triple structures.
    • $159
    In Stock
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