dimer

Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2

MSA-2 dimer, a selective and orally active non-nucleotide STING agonist with a dissociation constant (Kd) of 145 μM, demonstrates prolonged antitumor and immunogenic activity. It non-covalently binds to STING as a dimer, showing greater permeability compared to cyclic dinucleotide[1].

Oxytocin parallel dimer is a homo peptide dimer connected by a disulfide bridge.

Oxytocin antiparallel dimer is a disulfide-bridged homopeptide dimer.

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule with anti-inflammatory, antioxidant, and gastroprotective effects. It also modulates potassium channels independently of CO.

Nevirapine dimer is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

High affinity caveolin-1 (CAV1) ligand (Kd = 23 nM); disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL.

Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM).

ddC-AZT dimer is a biochemical.

Human D-dimer protein serves as an excellent biomarker for thrombosis. It is the final product of fibrinolysis.

N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits. N,N'-diacetyl-L-cystine is also an effective and orally active modulator of contact sensitivity/delayed-type hypersensitivity reactions in rodents.

Thiamine disulfide (Algoneurina) , also known as thiamin or vitamin B1, is a vitamin found in food and manufactured as a dietary supplement and medication. Thiamine also acts as a cofactor for many centrally metabolizing enzymes.

Ecamsule is a benzylidene camphor derivative, many of which are known for their excellent photostability. It can be added to many sunscreens to filter out UVA rays.

1,3-Butanediol (BD) is a ketogenic substance. Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity.

Perfluoro(2-methyl-3-oxahexanoic) acid (HFPO-DA) is a perfluoroalkyl ether carboxylic acid (PFECA), a contaminant in seawater and river water that induces apoptosis and increases reactive oxygen species (ROS) levels.

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.

MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].

SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.

(S,S)-D211 is a DNA damaging payload.

1,4-Dioxane-2,5-diol (Glycolaldehyde dimer) is a derivative of glycolaldehyde, the precursor to important compounds such as the amino acid glycine, and is involved in the formose reaction.

Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers and can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.

[Ir(cod)Cl]2 is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

[Ir(Cp-)Cl2]2 serves as a precursor for catalysts used in the asymmetric transfer hydrogenation of ketones. It is also employed as a catalyst in more environmentally friendly amine synthesis.

Osimertinibdimer is the dimer of Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutation-selective EGFR inhibitor, effectively suppressing L858R (IC50=12 nM) and L858R/T790M (IC50=1 nM) EGFR. It addresses resistance to EGFR inhibitors mediated by the T790M mutation in lung cancer.