fgfr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39001	FGFR-IN-1
	FGFR-IN-1 is a highly effective inhibitor targeting the Fibroblast Growth Factor Receptor (FGFR) group, comprising FGFR1, FGFR2, and FGFR3, with an impressive inhibitory concentration (IC 50) of less than 100 nM (US20130...
T37426	FIIN-1	FGFR irreversible inhibitor-1	FGFR
	FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2,...		FGFR
T5044	Futibatinib	TAS120,FGFR-IN-1	FGFR
	Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.		FGFR
T76672	Aprutumab	FGFR-moAb,FGFR2-TTC,BAY 1179470	FGFR
	Aprutumab (BAY 1179470) is a human FGFR2 monoclonal antibody with affinity to FGFR2 isoforms FGFR2-IIIB and FGFR2-IIIC. Aprutumab is commonly used to synthesize antibody-drug conjugates.		FGFR
T62794	FGFR-IN-5
	FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.
T62522	FGFR-IN-4
	FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.
T61528	FGFR-IN-7
	FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of ...
T79257	FGFR-IN-11		FGFR
	FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhi...		FGFR
T62391	FGFR-IN-6
	FGFR-IN-6 (Compound 5) is an FGFR inhibitor.
T64125	FGFR-IN-8
	FGFR-IN-8 is a potent, orally active FGFR inhibitor that inhibits both wild-type and mutant FGFR. FGFR-IN-8 acts on FGFR1 (IC50<0.5 nM), V564F-FGFR2 (IC5016: 189.1 nM), N549H-FGFR2 (IC50<0.5 nM), V555M-FGFR3 (IC50: 22.6 ...
T61660	FGFR-IN-3
	FGFR-IN-3 (compound 6) is a highly potent and orally active modulator of FGFR (fibroblast growth factor receptor). It has the ability to penetrate the blood-brain barrier (BBB). Additionally, FGFR-IN-3 exhibits significa...
T62653	FGFR-IN-2
	FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).
T73316	FGFR-IN-9
	FGFR-IN-9 is a potent, reversible, and orally active inhibitor of the fibroblast growth factor receptor (FGFR) family, demonstrating IC50 values of 17.1 nM for FGFR4 WT, 29.6 nM for FGFR3, 30.7 nM for FGFR4 V550L, 46.7 n...
TQ0256	FGFR4-IN-1		FGFR
	FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).		FGFR
T11279	FGFR1/DDR2 inhibitor 1		Discoidin Domain Receptor (DDR) , FGFR , Others
	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.		Discoidin Domain Receptor (DDR) , FGFR , Others
T6082	SSR128129E	SSR	FGFR
	SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.		FGFR
T6836	FIIN-2		FGFR
	FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.		FGFR
T2347	BLU9931		FGFR
	BLU9931 is the first selective small molecule inhibitor of FGFR4.		FGFR
T1948	AZD4547		VEGFR , FGFR
	AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).		VEGFR , FGFR
T3492	PD-166866	PD166866	FGFR , Autophagy
	PD-166866 is a selective FGFR tyrosine kinase inhibitor.		FGFR , Autophagy