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Cat No. | Product Name | Synonyms | Targets |
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TP1608 | PTD-p65-P1 Peptide | ||
PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition eff... | |||
TP1395 | PTD-p65-P1 Peptide TFA | ||
Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity indu... | |||
T8494 | NS-3-008 hydrochloride | NS-3-008 HCl | Others |
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). | |||
T6761 | Ossirene | AS101 | IL Receptor , Caspase , Interleukin |
Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. | |||
TD0099 | Malachite green oxalate | Apoptosis , Others , IκB/IKK , NF-κB | |
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. | |||
T82701 | CMV pp65(13-27) | ||
CMV pp65(13-27) is a bioactive peptide derived from the 65k lower matrix phosphoprotein of the human cytomegalovirus, specifically comprising amino acid residues 13 to 27. It includes a nine-amino-acid sequence (LGPISGHV... | |||
T25450 | GGTI 2147 | GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 | NF-κB , Rho |
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis. | |||
T11598 | IAXO-102 | TLR | |
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin... | |||
T6661 | SC75741 | Influenza Virus , NF-κB | |
SC75741 is a potent P65 inhibitor with IC50 of 200 nM | |||
T22021 | ACHP | IKK-2 Inhibitor VIII | IκB/IKK |
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression thro... | |||
T11886 | LTβR-IN-1 | Others , NF-κB , LTR | |
LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation o... | |||
T6454 | CORM-3 | CORM3 | Others , NF-κB , NOD-like Receptor (NLR) |
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. | |||
T1930 | JSH-23 | NF-κB | |
JSH-23, an NF-κB inhibitor(IC50= 7.1 μM), suppresses the transcriptional activity. | |||
T63107 | Anti-inflammatory agent 6 | ||
Anti-inflammatory agent 6 exhibits anti-inflammatory potential by blocking the phosphorylation of Iκb kinase α/β (IKKα/β), IκBα and nuclear factor kB p65 (NF-κb p65), which are key controllers of inflammation. | |||
T26226 | SRTCX1002 | SRTCX 1002,SRTCX-1002 | |
SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor. | |||
T27708 | K-14585 | ||
K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone incre... | |||
T28853 | SRTCX1003 | SRTCX-1003,SRTCX 1003 | |
SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. | |||
T28749 | SEMBL | ||
SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells. | |||
T83047 | Anti-inflammatory agent 65 | STING | |
Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation of IRF3 and p65, and disrupting the STING/IRF3/NF-κB signal... | |||
T78846 | EP12 | Apoptosis | |
EP12, a c-Myc inhibitor and G4 stabilizer, induces apoptosis and DNA damage in multiple myeloma cells while obstructing P65/P50 nuclear translocation by disrupting the NF-κB signaling pathway, effectively inhibiting mult... | |||
T83052 | Anti-inflammatory agent 60 | NF-κB | |
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin expression in a concentration-dependent manner [1]. | |||
T64018 | Anti-inflammatory agent 23 | ||
Anti-inflammatory agent 23 is an anti-inflammatory agent that inhibits LPS-activated NO production (IC50: 0.449 μM). anti-inflammatory agent 23 exhibits good affinity for p65 protein. | |||
T75013 | SB26019 | ||
SB26019 is a potent anti-neuroinflammatory compound that modulates the activation of NF-κB by promoting the formation of monomeric α-tubulin. This action of SB26019, in turn, hinders the translocation of p65, signifying ... | |||
T83661 | 17(R,S)-Benzo-Resolvin D1 | 17(R,S)-Benzo-RvD1,Benzo-RvD1 | |
Benzo-resolvin D1 (benzo-RvD1), a derivative of the specialized pro-resolving mediator (SPM) RvD1, effectively reduces PDGF-BB-induced cytoskeletal alterations and PDGF-triggered migration in isolated human vascular smoo... | |||
T71306 | Gemfibrozil-d6 | ||
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil redu... | |||
T75010 | TD1092 | ||
TD1092, a pan-IAP degrader, effectively degrades cIAP1, cIAP2, and XIAP, catalyzing the activation of Caspase 3/7 and fostering apoptosis in cancer cells through IAP degradation. It also obstructs the TNFα-mediated NF-κB... | |||
T78730 | TNF-α-IN-11 | ||
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM. By binding to TNF-α, it impedes TNF-α-induced caspase activation and the NF-κB signaling pathway. Additionally, it supp... | |||
T72383 | 3,3-Dimethyl-1-butanol | Neohexanol,DMB,DMB ; Neohexanol | |
3,3-Dimethyl-1-butanol (DMB) is an orally active compound that inhibits trimethylamine (TMA) and trimethylamine N-oxide (TMAO), along with the signaling pathways of p65 NF-κB and TGF-β1/Smad3. It holds potential for use ... | |||
T36191 | CAY10681 | ||
Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling. It potently binds MDM2 (Ki = 250 nM)... | |||
T74514 | HD-TAC7 | ||
HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-κB p65 in RAW 264.7 macrophages and is utilized in researc... | |||
T83670 | F1 TFA | Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide | |
F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel... | |||
T82189 | HMGB1-IN-2 | ||
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces... | |||
T79671 | NF-κB-IN-11 | NF-κB | |
NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB. It also reduces the expression levels of phospho-IKK, IκBα, and NF-κ... | |||
T36486 | Benpyrine | ||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten... | |||
T38263 | TBK1/IKKε-IN-4 | TBK1/IKKε-IN-4 | |
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
T8160 | EGCG Octaacetate | Others , Antibacterial | |
EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities. | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
T4237 | Rubiadin-1-methyl ether | Rubiadin 1-methyl ether | Anti-infection , NF-κB |
Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu... | |||
TN1786 | Isomerazin | Isomeranzin | ERK , NF-κB , AChE |
Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway. | |||
T2856 | (-)-Epicatechin | L-Epicatechin,Epicatechin,(-)-Epicatechol | Ferroptosis , COX , Endogenous Metabolite |
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. | |||
T6S0117 | Avicularin | Fenicularin | ERK |
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... | |||
T3772 | Maslinic acid | 2α-Hydroxyoleanoic Acid,2α-Hydroxyoleanolic acid,Crategolic acid | NF-κB , HIV Protease , DNA/RNA Synthesis , Antibacterial |
Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor. | |||
T4S1469 | Cucurbitacin IIb | Apoptosis , Others | |
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i... | |||
TN1674 | Garcinone D | Reactive Oxygen Species , Nrf2 , STAT | |
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti... | |||
T3012 | Mangiferin | Alpizarin,Chinomin,Hedysarid | Apoptosis , Others , NF-κB , Nrf2 |
Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L. | |||
T6S1256 | Ruscogenin | NOS , NF-κB , NOD-like Receptor (NLR) | |
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ... | |||
T6S1538 | Neochlorogenic acid | trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid | TNF , NF-κB , COX , Antibacterial , Interleukin |
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions. | |||
T2913 | Schisantherin A | Schisanwilsonin H,Gomisin-C,Wuweizi ester-A,Schizantherin-A,Arisanschinin K | NF-κB |
Schisantherin A (Wuweizi ester-A) is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent. | |||
TN1341 | 8-Deoxygartanin | Beta Amyloid , NF-κB , Parasite | |
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) a... | |||
T3753 | Sinapinic Acid | Sinapic acid,Synapoic acid | Apoptosis , RAAS , Reactive Oxygen Species , HDAC |
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... | |||
T15467 | Helenalin | Others | |
Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine ... | |||
TN5387 | Grasshopper ketone | ERK , p38 MAPK , NO Synthase , JNK | |
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 ... | |||
T27191 | D-Mannuronic Acid | ||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. | |||
TN1874 | Liriodendrin | ATPase , Potassium Channel , Prostaglandin Receptor | |
Liriodendrin regulates lung inflammation, the phosphorylation of the NF-kB (p65) and expression of vascular endothelial growth factor (VEGF). Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities a... | |||
TN3922 | Effusanin E | PARP , NF-κB , Caspase , COX , Antifection | |
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression . | |||
TN4490 | Manassantin B | ERK , BCL , p38 MAPK , TNF , NF-κB , JNK , STAT , Antifection | |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleu... | |||
TN1009 | Epimagnolin B | NF-κB , NO Synthase , Prostaglandin Receptor | |
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear transl... | |||
TN4635 | Neoechinulin A | NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor | |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-02387 | NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) | Human | E. coli |
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it fac... | |||
TMPJ-01426 | SARS-CoV-2 NSP2 Protein (His) | SARS-CoV-2 | E. coli |
The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins i... | |||
TMPH-02606 | CR1L Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor,... | |||
TMPY-04461 | TRIB3 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/T... | |||
TMPY-02893 | NT5C3A/NT5C3 Protein, Human, Recombinant | Human | E. coli |
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot... | |||
TMPJ-00338 | LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions u... |
Cat No. | Product Name | ||
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L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; |