ac3

Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly specific inhibitor of Calmodulin-Dependent Protein Kinase II (CaMKII) with enhanced resistance to proteolysis. This compound is a derivative of Autocamtide-3, where the Thr-9 phosphorylation site is replaced by Ala.

EAC3I, an autocamtide-3 derived inhibitory peptide with the sequence KKALHRQEAVDAL, is a bioactive peptide that mimics the autoinhibitory region of the CaMKII regulatory domain (residues 278–290). It functions by competitively binding to the enzyme's catalytic site.